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    Nqo1 NAD(P)H dehydrogenase, quinone 1 [ Mus musculus (house mouse) ]

    Gene ID: 18104, updated on 5-Nov-2024

    Summary

    Official Symbol
    Nqo1provided by MGI
    Official Full Name
    NAD(P)H dehydrogenase, quinone 1provided by MGI
    Primary source
    MGI:MGI:103187
    See related
    Ensembl:ENSMUSG00000003849 AllianceGenome:MGI:103187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dtd; Ox1; Qr1; Dia4; Nmo1; Ox-1; Nmo-1; Nmor1
    Summary
    Enables NAD(P)H dehydrogenase (quinone) activity and NADH:ubiquinone reductase (non-electrogenic) activity. Involved in several processes, including protein polyubiquitination; response to lipopolysaccharide; and vitamin K metabolic process. Acts upstream of or within negative regulation of catalytic activity and response to oxidative stress. Is active in cytoplasm and nucleus. Is expressed in heart; liver; main olfactory bulb; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 86.2), bladder adult (RPKM 36.2) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nqo1 in Genome Data Viewer
    Location:
    8 D3; 8 54.08 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108114856..108139012, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107388225..107403205, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22599 Neighboring gene ribosomal protein S18, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_22600 Neighboring gene nuclear factor of activated T cells 5 Neighboring gene STARR-positive B cell enhancer ABC_E9742 Neighboring gene predicted gene, 51546 Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene STARR-positive B cell enhancer ABC_E1107 Neighboring gene NIN1/RPN12 binding protein 1 homolog Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD(P)H dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD(P)H dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH:ubiquinone reductase (non-electrogenic) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NADH:ubiquinone reductase (non-electrogenic) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADPH dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NADH oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in NADPH oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to metal ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ferroptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ferroptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in removal of superoxide radicals ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to L-glutamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to L-glutamine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to carbohydrate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to flavonoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen sulfide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tetrachloromethane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquinone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquinone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vitamin E metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin E metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vitamin K metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD(P)H dehydrogenase [quinone] 1
    Names
    DT-diaphorase
    NAD(P)H dehydrogenase (quinone)
    NAD(P)H menadione oxidoreductase 1, dioxin inducible
    NAD(P)H:quinone oxidoreductase 1
    azoreductase
    diaphorase 4 (NADH/NADPH)
    menadione reductase
    phylloquinone reductase
    quinone reductase 1
    NP_032732.3
    XP_036009703.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008706.5NP_032732.3  NAD(P)H dehydrogenase [quinone] 1

      See identical proteins and their annotated locations for NP_032732.3

      Status: VALIDATED

      Source sequence(s)
      AA982077, AK075568
      Consensus CDS
      CCDS40465.1
      UniProtKB/Swiss-Prot
      Q64669
      UniProtKB/TrEMBL
      Q542Y0, Q99KL8
      Related
      ENSMUSP00000003947.9, ENSMUST00000003947.9
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      108114856..108139012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153810.1XP_036009703.1  NAD(P)H dehydrogenase [quinone] 1 isoform X1

      UniProtKB/Swiss-Prot
      Q64669
      UniProtKB/TrEMBL
      Q542Y0, Q99KL8
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold