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    Zfp445 zinc finger protein 445 [ Mus musculus (house mouse) ]

    Gene ID: 235682, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp445provided by MGI
    Official Full Name
    zinc finger protein 445provided by MGI
    Primary source
    MGI:MGI:2143340
    See related
    Ensembl:ENSMUSG00000047036 AllianceGenome:MGI:2143340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZNF168; Znf445; mszf29; mszf50
    Summary
    Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in epigenetic programing of female pronucleus and negative regulation of gene expression via chromosomal CpG island methylation. Located in nucleus. Is expressed in several structures, including cartilage condensation; early conceptus; forebrain; head bone; and urinary system. Orthologous to human ZNF445 (zinc finger protein 445). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 31.5), CNS E14 (RPKM 28.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp445 in Genome Data Viewer
    Location:
    9 F4; 9 73.18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122677988..122715916, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122848910..122886851, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6814 Neighboring gene T cell activation inhibitor, mitochondrial Neighboring gene predicted gene, 35549 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122775118-122775301 Neighboring gene zinc finger with KRAB and SCAN domains 7 Neighboring gene zinc finger protein 660 Neighboring gene zinc finger protein 105

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of KAP-1-associated complexes negatively regulating the Ey and β-major globin genes in the β-globin locus. Yang D, et al. J Proteomics, 2013 Mar 27. PMID 23291531
    2. ZNF445 is a primary regulator of genomic imprinting. Takahashi N, et al. Genes Dev, 2019 Jan 1. PMID 30602440, Free PMC Article
    3. Temporomandibular joint formation requires two distinct hedgehog-dependent steps. Purcell P, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19815519, Free PMC Article
    4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    5. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded methylated DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epigenetic programing of female pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epigenetic programing of female pronucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epigenetic programing of female pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 445

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359934.2 → NP_001346863.1  zinc finger protein 445 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125374
      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:231 → 289
      KRAB; krueppel associated box
      COG5048
      Location:566 → 995
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:648 → 668
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001359935.2 → NP_001346864.1  zinc finger protein 445 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125374
      Consensus CDS
      CCDS23648.1
      UniProtKB/Swiss-Prot
      A4FTX7, Q8K216, Q8R2V3
      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:219 → 277
      KRAB; krueppel associated box
      COG5048
      Location:554 → 983
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:636 → 656
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001421540.1 → NP_001408469.1  zinc finger protein 445 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125374

    4. NM_001421541.1 → NP_001408470.1  zinc finger protein 445 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125374
      UniProtKB/Swiss-Prot
      A4FTX7, Q8K216, Q8R2V3

    5. NM_001421542.1 → NP_001408471.1  zinc finger protein 445 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125374
      UniProtKB/Swiss-Prot
      A4FTX7, Q8K216, Q8R2V3

    6. NM_173364.6 → NP_775540.4  zinc finger protein 445 isoform 1

      See identical proteins and their annotated locations for NP_775540.4

      Status: VALIDATED

      Source sequence(s)
      AC125374
      Consensus CDS
      CCDS23648.1
      UniProtKB/Swiss-Prot
      A4FTX7, Q8K216, Q8R2V3
      UniProtKB/TrEMBL
      Q499F8
      Related
      ENSMUSP00000151198.2, ENSMUST00000216063.2
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:219 → 277
      KRAB; krueppel associated box
      COG5048
      Location:554 → 983
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:636 → 656
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122677988..122715916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512121.3 → XP_006512184.1  zinc finger protein 445 isoform X1

      See identical proteins and their annotated locations for XP_006512184.1

      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:231 → 289
      KRAB; krueppel associated box
      COG5048
      Location:566 → 995
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:648 → 668
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036154922.1 → XP_036010815.1  zinc finger protein 445 isoform X2

      UniProtKB/Swiss-Prot
      A4FTX7, Q8K216, Q8R2V3
      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:219 → 277
      KRAB; krueppel associated box
      COG5048
      Location:554 → 983
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:636 → 656
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_006512119.4 → XP_006512182.1  zinc finger protein 445 isoform X1

      See identical proteins and their annotated locations for XP_006512182.1

      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:231 → 289
      KRAB; krueppel associated box
      COG5048
      Location:566 → 995
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:648 → 668
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_006512118.3 → XP_006512181.1  zinc finger protein 445 isoform X1

      See identical proteins and their annotated locations for XP_006512181.1

      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:231 → 289
      KRAB; krueppel associated box
      COG5048
      Location:566 → 995
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:648 → 668
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_011242971.1 → XP_011241273.1  zinc finger protein 445 isoform X1

      See identical proteins and their annotated locations for XP_011241273.1

      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:231 → 289
      KRAB; krueppel associated box
      COG5048
      Location:566 → 995
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:648 → 668
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_006512122.3 → XP_006512185.1  zinc finger protein 445 isoform X1

      See identical proteins and their annotated locations for XP_006512185.1

      UniProtKB/TrEMBL
      Q499F8
      Conserved Domains (4) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      smart00349
      Location:231 → 289
      KRAB; krueppel associated box
      COG5048
      Location:566 → 995
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:648 → 668
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036154924.1 → XP_036010817.1  zinc finger protein 445 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:199 → 628
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2V3.2 GenPept UniProtKB/Swiss-Prot:Q8R2V3

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