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    Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 [ Mus musculus (house mouse) ]

    Gene ID: 69387, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dnajb13provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B13provided by MGI
    Primary source
    MGI:MGI:1916637
    See related
    Ensembl:ENSMUSG00000030708 AllianceGenome:MGI:1916637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsarg; 1700014P03Rik
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in axonemal central apparatus assembly and chaperone cofactor-dependent protein refolding. Located in axoneme; sperm flagellum; and sperm head-tail coupling apparatus. Part of radial spoke. Is expressed in several structures, including brain ventricle and choroid plexus; ventricular layer; and white fat. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 160.4) and ovary adult (RPKM 6.8) See more
    Orthologs
    human all
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    Genomic context

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    See Dnajb13 in Genome Data Viewer
    Location:
    7 E2; 7 54.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100152218..100182834, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100503011..100514815, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene uncoupling protein 3 (mitochondrial, proton carrier) Neighboring gene STARR-positive B cell enhancer mm9_chr7:107641658-107641958 Neighboring gene STARR-positive B cell enhancer ABC_E2244 Neighboring gene uncoupling protein 2 (mitochondrial, proton carrier) Neighboring gene STARR-seq mESC enhancer starr_19669 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107685672-107685781 Neighboring gene predicted gene, 39058 Neighboring gene cytochrome c oxidase assembly factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice. Oji A, et al. Sci Rep, 2016 Aug 17. PMID 27530713, Free PMC Article
    2. [Molecular cloning of mTSARG3 gene related to apoptosis in mouse spermatogenic cells]. Liu G, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Dec. PMID 14673507
    3. DNAJB13 is a radial spoke protein of mouse '9+2' axoneme. Guan J, et al. Reprod Domest Anim, 2010 Dec. PMID 19919626
    4. Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development. Guan J, et al. BMC Dev Biol, 2009 Mar 19. PMID 19298648, Free PMC Article
    5. [Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells]. Liu G, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2003 Apr. PMID 12673577

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that DNAJB13 participates in spermiogenesis and the motility of mature spermatozoa.
      Title: DNAJB13, a type II HSP40 family member, localizes to the spermatids and spermatozoa during mouse spermatogenesis.
    2. By multi-tissue reverse transcription polymerase chain reaction, we found that Dnajb13 gene was expressed not only in the testis but also in several other ciliated cell-containing tissues like brain, lung and oviduct.
      Title: DNAJB13 is a radial spoke protein of mouse '9+2' axoneme.
    3. The interaction of DNAJB13 with SEPT4 in vitro and its spatiotemporal association with the annulus during sperm flagellum development suggest that DNAJB13 may be involved in assembling the annulus structure.
      Title: Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development.
    4. DNAJB13 might be involved in assembly and stability of axoneme during sperm flagellum development.
      Title: A heat-shock protein 40, DNAJB13, is an axoneme-associated component in mouse spermatozoa.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal central apparatus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axonemal central apparatus assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cilium movement involved in extracellular fluid movement IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in flagellated sperm motility IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mating IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of radial spoke IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm head-tail coupling apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 13
    Names
    DnaJ (Hsp40) related, subfamily B, member 13
    spermatogenesis apoptosis-related protein
    testis and spermatogenesis cell-related protein 6
    testis spermatocyte apoptosis-related gene 6 protein
    testis spermatogenesis apoptosis-related gene 3 protein
    testis spermatogenesis apoptosis-related gene 6 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153527.3 → NP_705755.2  dnaJ homolog subfamily B member 13

      See identical proteins and their annotated locations for NP_705755.2

      Status: VALIDATED

      Source sequence(s)
      AC117215
      Consensus CDS
      CCDS21499.1
      UniProtKB/Swiss-Prot
      Q80Y75, Q8CJA2
      UniProtKB/TrEMBL
      A0A171EBK9
      Related
      ENSMUSP00000147019.2, ENSMUST00000207405.2
      Conserved Domains (3) summary
      cd10747
      Location:138 → 302
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 312
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain

    RNA

    1. NR_184865.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117215
      Related
      ENSMUST00000154516.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100152218..100182834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153418.1 → XP_036009311.1  dnaJ homolog subfamily B member 13 isoform X2

      Conserved Domains (1) summary
      cd10747
      Location:31 → 157
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    2. XM_006508184.3 → XP_006508247.1  dnaJ homolog subfamily B member 13 isoform X1

      UniProtKB/TrEMBL
      A0A171EBK9
      Conserved Domains (1) summary
      COG0484
      Location:18 → 307
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y75.1 GenPept UniProtKB/Swiss-Prot:Q80Y75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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