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    Tns3 tensin 3 [ Mus musculus (house mouse) ]

    Gene ID: 319939, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tns3provided by MGI
    Official Full Name
    tensin 3provided by MGI
    Primary source
    MGI:MGI:2443012
    See related
    Ensembl:ENSMUSG00000020422 AllianceGenome:MGI:2443012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TEM6; Tens1; F830010I22Rik
    Summary
    Enables guanyl-nucleotide exchange factor adaptor activity. Involved in positive regulation of guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including bone resorption; podosome assembly; and regulation of small GTPase mediated signal transduction. Located in podosome. Is expressed in several structures, including craniocervical region bone; foot mesenchyme; reproductive system; spleen primordium; and tail. Orthologous to human TNS3 (tensin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 31.3), ovary adult (RPKM 22.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tns3 in Genome Data Viewer
    Location:
    11 A1; 11 4.99 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (8381652..8614758, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (8431652..8664758, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA aspartic acid 10 (anticodon GTC) Neighboring gene predicted gene, 27393 Neighboring gene STARR-seq mESC enhancer starr_28503 Neighboring gene STARR-seq mESC enhancer starr_28504 Neighboring gene STARR-seq mESC enhancer starr_28506 Neighboring gene STARR-seq mESC enhancer starr_28507 Neighboring gene STARR-seq mESC enhancer starr_28508 Neighboring gene STARR-seq mESC enhancer starr_28509 Neighboring gene STARR-seq mESC enhancer starr_28511 Neighboring gene STARR-seq mESC enhancer starr_28512 Neighboring gene STARR-seq mESC enhancer starr_28518 Neighboring gene STARR-seq mESC enhancer starr_28520 Neighboring gene STARR-seq mESC enhancer starr_28524 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:8501700-8501809 Neighboring gene STARR-seq mESC enhancer starr_28532 Neighboring gene STARR-seq mESC enhancer starr_28533 Neighboring gene STARR-seq mESC enhancer starr_28537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:8600745-8600973 Neighboring gene STARR-seq mESC enhancer starr_28543 Neighboring gene STARR-seq mESC enhancer starr_28544 Neighboring gene STARR-seq mESC enhancer starr_28546 Neighboring gene predicted gene, 36772 Neighboring gene general transcription factor II A, 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination. Juilland M, et al. Proc Natl Acad Sci U S A, 2023 Dec 26. PMID 38109544, Free PMC Article
    2. Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation. Merour E, et al. Elife, 2022 Oct 10. PMID 36214451, Free PMC Article
    3. Tensins are versatile regulators of Rho GTPase signalling and cell adhesion. Blangy A. Biol Cell, 2017 Mar. PMID 27748980
    4. Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Chiang MK, et al. Dev Biol, 2005 Mar 15. PMID 15733665
    5. Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity. Touaitahuata H, et al. J Cell Sci, 2016 Sep 15. PMID 27505886

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
      Title: Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
    2. Dock5 and tensin 3 cooperate for osteoclast activity, to ensure the correct organization of podosomes.
      Title: Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.
    3. Tensin3 is a versatile regulator of DOCK5 signaling and cell adhesion. (Review)
      Title: Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.
    4. Tns3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.
      Title: The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.
    5. Results indicate that tensin3 is essential for normal development and functions of the small intestine, lung, and bone [tensin3].
      Title: Inactivation of tensin3 in mice results in growth retardation and postnatal lethality.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of Rac protein signal transduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tensin-3
    Names
    tensin-like SH2 domain containing 1
    tensin-like SH2 domain-containing protein 1
    tumor endothelial marker 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083587.1 → NP_001077056.1  tensin-3

      See identical proteins and their annotated locations for NP_001077056.1

      Status: VALIDATED

      Source sequence(s)
      AK052680, AK158101, AL603845, AL662881, AW259174, BU056564, BY154424
      Consensus CDS
      CCDS36109.1
      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Related
      ENSMUSP00000020695.7, ENSMUST00000020695.13
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      8381652..8614758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156761.1 → XP_036012654.1  tensin-3 isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (7) summary
      cd09927
      Location:1312 → 1428
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:943 → 1222
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:681 → 1113
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14561
      Location:157 → 315
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:322 → 448
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cd20889
      Location:69 → 124
      C1_TNS3_v; protein kinase C conserved region 1 (C1 domain) found in tensin-3 (TNS3) variant and similar proteins
      cl17171
      Location:1452 → 1511
      PH-like; Pleckstrin homology-like domain

    2. XM_036156762.1 → XP_036012655.1  tensin-3 isoform X3

      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    3. XM_006514741.3 → XP_006514804.1  tensin-3 isoform X3

      See identical proteins and their annotated locations for XP_006514804.1

      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    4. XM_036156764.1 → XP_036012657.1  tensin-3 isoform X3

      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    5. XM_011243728.4 → XP_011242030.1  tensin-3 isoform X3

      See identical proteins and their annotated locations for XP_011242030.1

      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    6. XM_011243727.3 → XP_011242029.1  tensin-3 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MP98, A0A5F8MPF2
      Related
      ENSMUSP00000158873.2, ENSMUST00000239091.2
      Conserved Domains (7) summary
      cd09927
      Location:1276 → 1392
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:907 → 1186
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:645 → 1077
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00029
      Location:35 → 81
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1416 → 1547
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:121 → 279
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:286 → 412
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    7. XM_030246087.1 → XP_030101947.1  tensin-3 isoform X3

      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    8. XM_036156763.1 → XP_036012656.1  tensin-3 isoform X3

      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    9. XM_006514740.4 → XP_006514803.2  tensin-3 isoform X3

      UniProtKB/Swiss-Prot
      Q3TZ54, Q5SSZ5, Q8BJA7
      UniProtKB/TrEMBL
      A0A5F8MPF2
      Conserved Domains (6) summary
      cd09927
      Location:1163 → 1279
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:794 → 1073
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:532 → 964
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1303 → 1434
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14561
      Location:8 → 166
      PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    10. XM_006514743.5 → XP_006514806.1  tensin-3 isoform X4

      Conserved Domains (3) summary
      cd09927
      Location:790 → 906
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:421 → 700
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:930 → 1061
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    RNA

    1. XR_380972.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SSZ5.1 GenPept UniProtKB/Swiss-Prot:Q5SSZ5

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