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    Tkt transketolase [ Mus musculus (house mouse) ]

    Gene ID: 21881, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Tktprovided by MGI
    Official Full Name
    transketolaseprovided by MGI
    Primary source
    MGI:MGI:105992
    See related
    Ensembl:ENSMUSG00000021957 AllianceGenome:MGI:105992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p68
    Summary
    This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013]
    Expression
    Broad expression in mammary gland adult (RPKM 585.4), adrenal adult (RPKM 535.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tkt in Genome Data Viewer
    Location:
    14 B; 14 18.79 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30271088..30296681)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30549131..30574724)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1D subunit Neighboring gene RIKEN cDNA 4831407H17 gene Neighboring gene STARR-seq mESC enhancer starr_36297 Neighboring gene predicted gene, 35566 Neighboring gene decapping mRNA 1A Neighboring gene STARR-positive B cell enhancer ABC_E7300 Neighboring gene STARR-seq mESC enhancer starr_36303 Neighboring gene STARR-positive B cell enhancer ABC_E11567 Neighboring gene STARR-positive B cell enhancer ABC_E2422 Neighboring gene microRNA 3076 Neighboring gene predicted gene, 52147 Neighboring gene protein kinase C, delta Neighboring gene predicted gene, 53839

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells. Schimmer BP, et al. J Biol Chem, 1996 Mar 1. PMID 8617775
    2. Transketolase and protein oxidation of senescence accelerated mouse. Nakamura J, et al. Biofactors, 2000. PMID 10705983
    3. Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency. Zhao Y, et al. J Neurochem, 2009 Oct. PMID 19686241
    4. The mouse transketolase (TKT) gene: cloning, characterization, and functional promoter analysis. Salamon C, et al. Genomics, 1998 Mar 1. PMID 9521875
    5. Heterogeneous expression of transketolase in ocular tissues. Guo J, et al. Curr Eye Res, 1997 May. PMID 9154385

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway.
      Title: HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway.
    2. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics.
      Title: Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics.
    3. Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis.
      Title: Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis.
    4. TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis.
      Title: TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis.
    5. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
      Title: Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
    6. Zinc finger protein 746 overexpression suppresses TKT transcription via IRS-like motif in the TKT promoter.
      Title: Identification of transketolase as a target of PARIS in substantia nigra.
    7. decreased TK activity leads to pentose-phosphate pathway dysfunction and contributes to impaired hippocampal neurogenesis induced by thiamine deficiency
      Title: Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transketolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transketolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glyceraldehyde-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt, non-oxidative branch ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xylulose 5-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transketolase
    Names
    TK
    NP_033414.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009388.6 → NP_033414.1  transketolase

      See identical proteins and their annotated locations for NP_033414.1

      Status: REVIEWED

      Source sequence(s)
      AC154646, AI837706, AK030446, AK166763, BY276711
      Consensus CDS
      CCDS26894.1
      UniProtKB/Swiss-Prot
      P40142, Q3U7Y1, Q3UK62, Q545A1, Q9ESA0
      UniProtKB/TrEMBL
      A0A286YE28
      Related
      ENSMUSP00000022529.7, ENSMUST00000022529.8
      Conserved Domains (4) summary
      cd07033
      Location:319 → 474
      TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
      PRK05899
      Location:8 → 620
      PRK05899; transketolase; Reviewed
      cd02012
      Location:20 → 271
      TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
      pfam02780
      Location:492 → 612
      Transketolase_C; Transketolase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30271088..30296681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40142.1 GenPept UniProtKB/Swiss-Prot:P40142

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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