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Shh sonic hedgehog [ Mus musculus (house mouse) ]

Gene ID: 20423, updated on 2-Nov-2024

Summary

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Official Symbol: Shhprovided by MGI
Official Full Name: sonic hedgehogprovided by MGI
Primary source: MGI:MGI:98297
See related: Ensembl:ENSMUSG00000002633 AllianceGenome:MGI:98297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hx; Dsh; Hhg1; Hxl3; HHG-1; ShhNC; M100081; 9530036O11Rik
Summary: Enables several functions, including cholesterol-protein transferase activity; laminin-1 binding activity; and patched binding activity. Involved in several processes, including hemopoiesis; positive regulation of T cell activation; and regulation of smooth muscle cell differentiation. Acts upstream of or within several processes, including nervous system development; respiratory system development; and tube morphogenesis. Located in several cellular components, including cell surface; extracellular space; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study brachydactyly type A1; holoprosencephaly 3; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and solitary median maxillary central incisor. Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 27.9), adrenal adult (RPKM 21.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

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See Shh in Genome Data Viewer

Location:: 5 B1; 5 14.39 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (28661838..28672099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (28456840..28467101, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impact of Sonic Hedgehog-dependent sphenoid bone defect on craniofacial growth.
Title: Impact of Sonic Hedgehog-dependent sphenoid bone defect on craniofacial growth.
Characterization of Sonic Hedgehog transcripts in the adult mouse brain: co-expression with neuronal and oligodendroglial markers.
Title: Characterization of Sonic Hedgehog transcripts in the adult mouse brain: co-expression with neuronal and oligodendroglial markers.
TRIP6 promotes neural stem cell maintenance through YAP-mediated Sonic Hedgehog activation.
Title: TRIP6 promotes neural stem cell maintenance through YAP-mediated Sonic Hedgehog activation.
SALL4 is a CRL3[REN/KCTD11] substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Title: SALL4 is a CRL3(REN/KCTD11) substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression.
Title: Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression.
Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis.
Title: Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis.
Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration.
Title: Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration.
[Effect study of Sonic hedgehog overexpressed hair follicle stem cells in hair follicle regeneration].
Title: [Effect study of Sonic hedgehog overexpressed hair follicle stem cells in hair follicle regeneration].
The SHH-GLI1 pathway is required in skin expansion and angiogenesis.
Title: The SHH-GLI1 pathway is required in skin expansion and angiogenesis.
IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.
Title: IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.

Submit: New GeneRIF Correction See all GeneRIFs (761)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3)
Endonuclease-mediated (5)
Radiation induced (1)
Targeted (21) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Shh (e-PCR), detects polymorphism
- UniSTS:254229

Shh (e-PCR), detects polymorphism
- UniSTS:234043

Shh (e-PCR), detects polymorphism
- UniSTS:465494

Shh (e-PCR), detects polymorphism
- UniSTS:238169

Shh (e-PCR), detects polymorphism
- UniSTS:547469

Shh (e-PCR), detects polymorphism
- UniSTS:166294

Shh (e-PCR), detects polymorphism
- UniSTS:496808

Shh (e-PCR), detects polymorphism
- UniSTS:528041

Shh (e-PCR), detects polymorphism
- UniSTS:496610

Shh (e-PCR), detects polymorphism
- UniSTS:547824

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosaminoglycan binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables laminin-1 binding	IDA Inferred from Direct Assay more info	PubMed
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables patched binding	IPI Inferred from Physical Interaction more info	PubMed
enables patched binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alpha-tubulin acetylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within anatomical structure development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within androgen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within artery development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within artery development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bud outgrowth involved in lung branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell proliferation in external granule layer	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebellar granule cell precursor proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in commissural neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right asymmetry in lateral mesoderm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract mesoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within dorsal/ventral neural tube patterning	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral neural tube patterning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial-mesenchymal cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial-mesenchymal signaling involved in prostate gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell polarity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within formation of anatomical boundary	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungiform papilla development	ISO Inferred from Sequence Orthology more info
involved_in fungiform papilla formation	ISO Inferred from Sequence Orthology more info
involved_in fungiform papilla morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intein-mediated protein splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intermediate filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within left lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within limb bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within limb development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within limb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung lobe morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung-associated mesenchyme development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphoid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphoid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mesenchymal smoothened signaling pathway involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in prostate gland development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in metanephric collecting duct development	IEA Inferred from Electronic Annotation more info
involved_in metanephric mesenchymal cell proliferation involved in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of kidney smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ureter smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within odontogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IDA Inferred from Direct Assay more info	PubMed
involved_in oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oligodendrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within osteoblast development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern specification process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kidney smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesenchymal cell proliferation involved in ureter development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotrophin production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of oligodendrocyte progenitor proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sclerotome development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sclerotome development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of skeletal muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ureter smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primary prostatic bud elongation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within prostate epithelial cord elongation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within prostatic bud formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mesenchymal cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of prostatic bud formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of prostatic bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within right lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within salivary gland cavitation	IDA Inferred from Direct Assay more info	PubMed
involved_in self proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of skeletal muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in somite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stem cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within striated muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within striated muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telencephalon regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telencephalon regionalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thalamus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thalamus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tongue development	ISO Inferred from Sequence Orthology more info
involved_in tongue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trachea development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trachea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tracheoesophageal septum formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of trunk neural crest cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in vasculogenesis involved in coronary vascular morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron specification	ISO Inferred from Sequence Orthology more info
involved_in zona limitans intrathalamica formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sonic hedgehog protein

Names: hemimelic extra toes; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; short digits

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429000.1 → NP_001415929.1 sonic hedgehog protein isoform 2

Status: VALIDATED

Source sequence(s)

AC134530
NM_009170.4 → NP_033196.1 sonic hedgehog protein isoform 1 precursor

See identical proteins and their annotated locations for NP_033196.1

Status: VALIDATED

Source sequence(s)

AC134530

Consensus CDS

CCDS19146.1

UniProtKB/Swiss-Prot

Q62226

UniProtKB/TrEMBL

Q8C765

Related

ENSMUSP00000002708.4, ENSMUST00000002708.5

Conserved Domains (3) summary

cd00081
Location:199 → 349

Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...

pfam01079
Location:188 → 423

Hint; Hint module

pfam01085
Location:40 → 185

HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

28661838..28672099 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535649.5 → XP_006535712.1 sonic hedgehog protein isoform X2

Conserved Domains (2) summary

pfam01079
Location:74 → 309

Hint; Hint module

pfam01085
Location:1 → 71

HH_signal; Hedgehog amino-terminal signalling domain
XM_006535648.4 → XP_006535711.1 sonic hedgehog protein isoform X1

Conserved Domains (2) summary

pfam01079
Location:97 → 332

Hint; Hint module

pfam01085
Location:10 → 94

HH_signal; Hedgehog amino-terminal signalling domain