U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rsf1 remodeling and spacing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 233532, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rsf1provided by MGI
    Official Full Name
    remodeling and spacing factor 1provided by MGI
    Primary source
    MGI:MGI:2682305
    See related
    Ensembl:ENSMUSG00000035623 AllianceGenome:MGI:2682305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XAP8; p325; Gm164; Hbxap; 4832420A03Rik; C030033M12Rik
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in several processes, including nucleosome assembly; positive regulation of viral transcription; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of RSF complex. Is expressed in several structures, including ear; genitourinary system; and nervous system. Orthologous to human RSF1 (remodeling and spacing factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.7), CNS E14 (RPKM 4.1) and 24 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rsf1 in Genome Data Viewer
    Location:
    7 E1; 7 53.55 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97229103..97341989)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97579870..97692782)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 4 Neighboring gene predicted gene, 24412 Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene STARR-seq mESC enhancer starr_19602 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, pseudogene 1 Neighboring gene ribosomal protein L15, pseudogene 5 Neighboring gene remodeling and spacing factor 1, opposite strand 1 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104787388-104787688 Neighboring gene STARR-seq mESC enhancer starr_19603 Neighboring gene remodeling and spacing factor 1, opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E11361 Neighboring gene chloride channel, nucleotide-sensitive, 1A Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104870902-104871089 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104872316-104872580 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104879154-104879355 Neighboring gene aquaporin 11

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs. Hung L, et al. FEBS Lett, 2004 Feb 27. PMID 14988024
    2. The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores. Lee HS, et al. Nat Commun, 2015 Aug 10. PMID 26259146, Free PMC Article
    3. Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing. Zhang Z, et al. Proc Natl Acad Sci U S A, 2017 Sep 19. PMID 28855339, Free PMC Article
    4. Chromatin-remodeling factor, RSF1, controls p53-mediated transcription in apoptosis upon DNA strand breaks. Min S, et al. Cell Death Dis, 2018 Oct 22. PMID 30348983, Free PMC Article
    5. CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis. Thompson PJ, et al. J Mol Biol, 2012 Feb 3. PMID 22154806

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data identify RSF1 as a H2Aub reader that contributes to H2Aub-mediated gene silencing by maintaining a stable nucleosome pattern at promoter regions.
      Title: Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing.
    2. Small interfering RNAs have specific inhibition of Hbxap expression and transactivation.
      Title: Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC90806

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RSF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    remodeling and spacing factor 1
    Names
    hepatitis B virus x associated protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081267.2 → NP_001074736.1  remodeling and spacing factor 1

      Status: VALIDATED

      Source sequence(s)
      AC124541, AC149605, AC151477
      Consensus CDS
      CCDS40025.1
      UniProtKB/TrEMBL
      E9PWW9
      Related
      ENSMUSP00000102771.3, ENSMUST00000107153.3
      Conserved Domains (4) summary
      cd15543
      Location:896 → 941
      PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
      pfam15612
      Location:103 → 153
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:155 → 187
      WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
      cl02608
      Location:918 → 971
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97229103..97341989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous