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    Meis3 Meis homeobox 3 [ Mus musculus (house mouse) ]

    Gene ID: 17537, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Meis3provided by MGI
    Official Full Name
    Meis homeobox 3provided by MGI
    Primary source
    MGI:MGI:108519
    See related
    Ensembl:ENSMUSG00000041420 AllianceGenome:MGI:108519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrg2
    Summary
    The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Expression
    Broad expression in whole brain E14.5 (RPKM 38.1), CNS E14 (RPKM 35.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Meis3 in Genome Data Viewer
    Location:
    7 A2; 7 8.76 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15908684..15920435)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16174012..16186510)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6515 Neighboring gene kaptin Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16786573-16786682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16792577-16792686 Neighboring gene DExH-box helicase 34 Neighboring gene STARR-positive B cell enhancer ABC_E1334 Neighboring gene STARR-seq mESC enhancer starr_18126 Neighboring gene predicted gene, 26473 Neighboring gene complement component 5a receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells. Hara T, et al. Oncogene, 2008 Jun 19. PMID 18223676
    2. Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Liu J, et al. Proc Natl Acad Sci U S A, 2010 Nov 23. PMID 21059917, Free PMC Article
    3. Characterization of TALE genes expression during the first lineage segregation in mammalian embryos. Sonnet W, et al. Dev Dyn, 2012 Nov. PMID 22987645
    4. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis. Wagner K, et al. Mech Dev, 2001 May. PMID 11335119
    5. PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects. Qin P, et al. Teratology, 2002 Nov. PMID 12397630

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse.
      Title: Characterization of TALE genes expression during the first lineage segregation in mammalian embryos.
    2. Meis3 is abundantly expressed in pancreatic islets and beta-cells and regulates beta-cell survival through 3-phosphoinositide-dependent protein kinase 1 (PDK1).
      Title: Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.
    3. Novel collaboration between Icsbp deficiency and Meis1/Meis3 in the acceleration of chronic myeloid leukemia-like disease.
      Title: Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells.
    4. The mRNA level of this protein was elevated in limb buds after treatment with ectopic acid.
      Title: PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144812, MGC144813

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein Meis3
    Names
    meis1-related protein 2
    myeloid ecotropic viral integration site-related gene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277988.3 → NP_001264917.1  homeobox protein Meis3 isoform b

      See identical proteins and their annotated locations for NP_001264917.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, and 6 all encode the same isoform (b).
      Source sequence(s)
      AC156630
      Consensus CDS
      CCDS71892.1
      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. NM_001277989.3 → NP_001264918.1  homeobox protein Meis3 isoform b

      See identical proteins and their annotated locations for NP_001264918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon and differs in the 3' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, and 6 all encode the same isoform (b).
      Source sequence(s)
      AC156630
      Consensus CDS
      CCDS71892.1
      UniProtKB/TrEMBL
      Q3U2C1
      Related
      ENSMUSP00000134918.2, ENSMUST00000176506.8
      Conserved Domains (2) summary
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. NM_001302472.2 → NP_001289401.1  homeobox protein Meis3 isoform a

      See identical proteins and their annotated locations for NP_001289401.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Variants 1 and 5 both encode the same isoform (a).
      Source sequence(s)
      AC156630
      Consensus CDS
      CCDS39782.1
      UniProtKB/Swiss-Prot
      P97368, Q149R5, Q99L81
      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. NM_001417025.1 → NP_001403954.1  homeobox protein Meis3 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC156630

    5. NM_001417026.1 → NP_001403955.1  homeobox protein Meis3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC156630

    6. NM_008627.5 → NP_032653.2  homeobox protein Meis3 isoform a

      See identical proteins and their annotated locations for NP_032653.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 5 both encode the same isoform (a).
      Source sequence(s)
      AC156630
      Consensus CDS
      CCDS39782.1
      UniProtKB/Swiss-Prot
      P97368, Q149R5, Q99L81
      UniProtKB/TrEMBL
      Q3U2C1
      Related
      ENSMUSP00000002495.11, ENSMUST00000002495.18
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RNA

    1. NR_102730.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC156630
      Related
      ENSMUST00000177156.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      15908684..15920435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539603.5 → XP_006539666.1  homeobox protein Meis3 isoform X3

      See identical proteins and their annotated locations for XP_006539666.1

      UniProtKB/Swiss-Prot
      P97368, Q149R5, Q99L81
      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_036152757.1 → XP_036008650.1  homeobox protein Meis3 isoform X14

      Conserved Domains (2) summary
      pfam05920
      Location:216 → 255
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 135
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. XM_036152746.1 → XP_036008639.1  homeobox protein Meis3 isoform X4

      UniProtKB/TrEMBL
      Q148B2
      Conserved Domains (2) summary
      pfam05920
      Location:305 → 344
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 205
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. XM_036152756.1 → XP_036008649.1  homeobox protein Meis3 isoform X13

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:233 → 272
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    5. XM_036152753.1 → XP_036008646.1  homeobox protein Meis3 isoform X10

      UniProtKB/TrEMBL
      Q148B2
      Conserved Domains (2) summary
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    6. XM_036152751.1 → XP_036008644.1  homeobox protein Meis3 isoform X8

      UniProtKB/TrEMBL
      Q148B2
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    7. XM_036152748.1 → XP_036008641.1  homeobox protein Meis3 isoform X7

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:255 → 294
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 174
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    8. XM_036152750.1 → XP_036008643.1  homeobox protein Meis3 isoform X8

      UniProtKB/TrEMBL
      Q148B2
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    9. XM_036152744.1 → XP_036008637.1  homeobox protein Meis3 isoform X1

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:305 → 344
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 205
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    10. XM_036152749.1 → XP_036008642.1  homeobox protein Meis3 isoform X8

      UniProtKB/TrEMBL
      Q148B2
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    11. XM_036152745.1 → XP_036008638.1  homeobox protein Meis3 isoform X2

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:288 → 327
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 188
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    12. XM_036152743.1 → XP_036008636.1  homeobox protein Meis3 isoform X1

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:305 → 344
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 205
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    13. XM_030242197.2 → XP_030098057.1  homeobox protein Meis3 isoform X11

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:233 → 272
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    14. XM_036152755.1 → XP_036008648.1  homeobox protein Meis3 isoform X12

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:216 → 255
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 135
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    15. XM_036152747.1 → XP_036008640.1  homeobox protein Meis3 isoform X5

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    16. XM_036152752.1 → XP_036008645.1  homeobox protein Meis3 isoform X9

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:249 → 288
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 149
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    17. XM_036152754.1 → XP_036008647.1  homeobox protein Meis3 isoform X11

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:233 → 272
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    18. XM_006539605.5 → XP_006539668.1  homeobox protein Meis3 isoform X6

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    19. XM_030242194.2 → XP_030098054.1  homeobox protein Meis3 isoform X3

      UniProtKB/Swiss-Prot
      P97368, Q149R5, Q99L81
      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    20. XM_030242195.2 → XP_030098055.1  homeobox protein Meis3 isoform X5

      UniProtKB/TrEMBL
      Q3U2C1
      Conserved Domains (2) summary
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    21. XM_030242198.2 → XP_030098058.1  homeobox protein Meis3 isoform X15

      Conserved Domains (2) summary
      pfam05920
      Location:156 → 195
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:26 → 56
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RNA

    1. XR_004934026.1 RNA Sequence

    2. XR_004934025.1 RNA Sequence

    3. XR_004934027.1 RNA Sequence

    4. XR_004934028.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97368.2 GenPept UniProtKB/Swiss-Prot:P97368

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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