Gsto1 glutathione S-transferase omega 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsto1provided by MGI
Official Full Name: glutathione S-transferase omega 1provided by MGI
Primary source: MGI:MGI:1342273
See related: Ensembl:ENSMUSG00000025068 AllianceGenome:MGI:1342273
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p28; Gstx; Spg-r; Gsto-1
Summary: This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015]
Expression: Broad expression in stomach adult (RPKM 297.2), bladder adult (RPKM 158.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D1; 19 40.41 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47843412..47853229)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47854973..47864790)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of glutathione S-transferase omega 1-catalyzed protein deglutathionylation suppresses adipocyte differentiation.
Title: Inhibition of glutathione S-transferase omega 1-catalyzed protein deglutathionylation suppresses adipocyte differentiation.
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Title: Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation.
Title: ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation.
Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
Title: Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1alpha-induced eosinophilic airway inflammation.
Title: GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1α-induced eosinophilic airway inflammation.
The potential therapeutic utility of GSTO1-1 inhibitors in the modulation of inflammation.
Title: GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
These results indicate that GSTO1-1 is required for inflammatory-mediated photoreceptor death in retinal degenerations. Targeting GSTO1-1 may be a useful strategy to reduce oxidative stress and inflammation and ameliorate photoreceptor loss, slowing the progression of retinal degenerations.
Title: Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina.
Data indicate that GSTO1-1 is required for LPS-mediated signalling in macrophages and that it acts early in the LPS-TLR4 pro-inflammatory pathway.
Title: GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway.
shRNA knockdown of GSTO1-1 in macrophage-like J774.1A cells blocks the expression of NADPH oxidase 1 and the generation of reactive oxygen species after Bacterial lipopolysaccharide stimulation.
Title: Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.
Genes encoding the antioxidants GPX2 and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
Title: Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Not Specified (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gsto1 (e-PCR), detects polymorphism
- UniSTS:506959

RH136264 (e-PCR)
- UniSTS:210257

U80819 (e-PCR)
- UniSTS:160858

RH125650 (e-PCR)
- UniSTS:162436

RH135920 (e-PCR)
- UniSTS:209917

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione dehydrogenase (ascorbate) activity	ISO Inferred from Sequence Orthology more info
enables glutathione dehydrogenase (ascorbate) activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methylarsonate reductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ascorbic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arsenic-containing substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to arsenic-containing substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase omega-1

Names: Glutathione transferase omega 1 (GSTO 1-1) (p28); MMA(V) reductase; S-(Phenacyl)glutathione reductase; glutathione S-transferase omega 1-1; glutathione-S-transferase like; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase

NP_034492.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010362.3 → NP_034492.1 glutathione S-transferase omega-1

See identical proteins and their annotated locations for NP_034492.1

Status: REVIEWED

Source sequence(s)

AC126679, AI846704, AK146834, BE860946

Consensus CDS

CCDS29893.1

UniProtKB/Swiss-Prot

O09131, Q3TH87

Related

ENSMUSP00000026050.8, ENSMUST00000026050.8

Conserved Domains (3) summary

cd03184
Location:108 → 228

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

COG0625
Location:26 → 224

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03055
Location:5 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...