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    Dusp18 dual specificity phosphatase 18 [ Mus musculus (house mouse) ]

    Gene ID: 75219, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dusp18provided by MGI
    Official Full Name
    dual specificity phosphatase 18provided by MGI
    Primary source
    MGI:MGI:1922469
    See related
    Ensembl:ENSMUSG00000047205 AllianceGenome:MGI:1922469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DSP18; DUSP20; LMWDSP20; 4930527G07Rik
    Summary
    Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein targeting to membrane; protein targeting to mitochondrion; and response to antibiotic. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and nucleoplasm. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Orthologous to human DUSP18 (dual specificity phosphatase 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 4.6), testis adult (RPKM 2.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dusp18 in Genome Data Viewer
    Location:
    11 A1; 11 2.74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3844940..3851299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3894935..3901299)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_28364 Neighboring gene predicted gene, 51880 Neighboring gene STARR-seq mESC enhancer starr_28365 Neighboring gene STARR-positive B cell enhancer ABC_E8382 Neighboring gene RIKEN cDNA 4921536K21 gene Neighboring gene nucleolar protein 8 pseudogene Neighboring gene solute carrier family 35, member E4 Neighboring gene transcobalamin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer. Zhou X, et al. Nat Commun, 2024 Jul 12. PMID 38992029, Free PMC Article
    2. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. Romá-Mateo C, et al. J Mol Biol, 2007 Dec 7. PMID 17976645
    3. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, et al. J Biol Chem, 2008 May 30. PMID 18385140, Free PMC Article
    4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.
      Title: Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.
    2. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane
      Title: Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein localization to organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in extrinsic component of mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 18
    Names
    low molecular weight dual specificity phosphatase 20
    NP_776106.1
    XP_006514936.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173745.5 → NP_776106.1  dual specificity protein phosphatase 18

      See identical proteins and their annotated locations for NP_776106.1

      Status: VALIDATED

      Source sequence(s)
      AK052827, AK081916, BB512576, CN536942
      Consensus CDS
      CCDS24369.1
      UniProtKB/Swiss-Prot
      Q8VE01
      Related
      ENSMUSP00000057346.5, ENSMUST00000055931.5
      Conserved Domains (1) summary
      cl28904
      Location:19 → 176
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3844940..3851299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514873.4 → XP_006514936.1  dual specificity protein phosphatase 18 isoform X1

      See identical proteins and their annotated locations for XP_006514936.1

      UniProtKB/Swiss-Prot
      Q8VE01
      Conserved Domains (1) summary
      cl28904
      Location:19 → 176
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE01.1 GenPept UniProtKB/Swiss-Prot:Q8VE01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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