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    mef2aa myocyte enhancer factor 2aa [ Danio rerio (zebrafish) ]

    Gene ID: 30564, updated on 14-Nov-2024

    Summary

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    Official Symbol
    mef2aaprovided by ZNC
    Official Full Name
    myocyte enhancer factor 2aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-163
    See related
    Ensembl:ENSDARG00000031756 AllianceGenome:ZFIN:ZDB-GENE-990415-163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mef2a; wu:fd19d02; etID309779.18
    Summary
    Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including myofibril assembly; positive regulation of macromolecule biosynthetic process; and somitogenesis. Predicted to be located in nucleus. Is expressed in cardiovascular system; myotome; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mef2aa in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (23187418..23361540)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (23198545..23369782)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene core-binding factor subunit beta Neighboring gene uncharacterized LOC137488280 Neighboring gene uncharacterized LOC103909137 Neighboring gene multiple C2 domains, transmembrane 2a Neighboring gene uncharacterized LOC137488281 Neighboring gene uncharacterized LOC110438093

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation of a mef2aa:EGFP transgenic zebrafish line that expresses EGFP in muscle cells. Lv F, et al. Fish Physiol Biochem, 2017 Feb. PMID 27632017
    2. Expression characterization and the promoter activity analysis of zebrafish hdac4. Zhu K, et al. Fish Physiol Biochem, 2012 Apr. PMID 21773810
    3. Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos. Ticho BS, et al. Mech Dev, 1996 Oct. PMID 8951797
    4. Promoter analysis of ventricular myosin heavy chain (vmhc) in zebrafish embryos. Jin D, et al. Dev Dyn, 2009 Jul. PMID 19517572, Free PMC Article
    5. Distinct modes of vertebrate hypaxial muscle formation contribute to the teleost body wall musculature. Windner SE, et al. Dev Genes Evol, 2011 Aug. PMID 21720828, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mef2 controls skeletal muscle formation after terminal differentiation.
      Title: Mef2s are required for thick filament formation in nascent muscle fibres.
    2. Results suggest that myocyte-specific enhancer factor 2A is essential for cardiac contractility
      Title: Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility.
    3. Results suggest that myocyte enhancer factor 2A is essential for zebrafish posterior somite development.
      Title: Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myocyte enhancer factor 2aa
    Names
    myocyte-specific enhancer factor 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131301.2 → NP_571376.2  myocyte enhancer factor 2aa

      Status: VALIDATED

      Source sequence(s)
      BX323877, EB903808, EH440607, EH466515
      UniProtKB/TrEMBL
      A0A8M1PBS7, Q1LXH6
      Related
      ENSDARP00000116960.1, ENSDART00000148106.3
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:98 → 151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      23187418..23361540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214714.1 → XP_068070815.1  myocyte enhancer factor 2aa isoform X1

    2. XM_068214713.1 → XP_068070814.1  myocyte enhancer factor 2aa isoform X1

    3. XM_021467574.2 → XP_021323249.1  myocyte enhancer factor 2aa isoform X3

      UniProtKB/TrEMBL
      A0A8M9PF86
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:141 → 196
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    4. XM_005159042.5 → XP_005159099.1  myocyte enhancer factor 2aa isoform X4

      See identical proteins and their annotated locations for XP_005159099.1

      UniProtKB/TrEMBL
      A0A8M2B5Z6
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:142 → 196
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    5. XM_068214715.1 → XP_068070816.1  myocyte enhancer factor 2aa isoform X2

    6. XM_005159044.5 → XP_005159101.1  myocyte enhancer factor 2aa isoform X5

      UniProtKB/TrEMBL
      A0A8M2B5M2
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:142 → 196
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    7. XM_068214718.1 → XP_068070819.1  myocyte enhancer factor 2aa isoform X8

    8. XM_068214719.1 → XP_068070820.1  myocyte enhancer factor 2aa isoform X9

    9. XM_021467580.2 → XP_021323255.1  myocyte enhancer factor 2aa isoform X10

      UniProtKB/TrEMBL
      A0A8M9PPZ2
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:98 → 151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    10. XM_068214716.1 → XP_068070817.1  myocyte enhancer factor 2aa isoform X6

    11. XM_021467577.2 → XP_021323252.1  myocyte enhancer factor 2aa isoform X12

      UniProtKB/TrEMBL
      A0A8M9P0X9
      Related
      ENSDARP00000021792.9, ENSDART00000005740.11
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    12. XM_005159045.5 → XP_005159102.1  myocyte enhancer factor 2aa isoform X11

      UniProtKB/TrEMBL
      A0A0R4IRM3, A0A8M2B5I3
      Related
      ENSDARP00000139238.1, ENSDART00000171594.2
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:98 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    13. XM_068214717.1 → XP_068070818.1  myocyte enhancer factor 2aa isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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