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    mapk12a mitogen-activated protein kinase 12a [ Danio rerio (zebrafish) ]

    Gene ID: 30681, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mapk12aprovided by ZNC
    Official Full Name
    mitogen-activated protein kinase 12aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-257
    See related
    Ensembl:ENSDARG00000042021 AllianceGenome:ZFIN:ZDB-GENE-990415-257
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    erk6; sapk3; mapk12; fa05c12; wu:fa05c12; zgc:101695; etID309866.18
    Summary
    Predicted to enable MAP kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; epidermis; otic vesicle; polster; and pronephric duct. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mapk12a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (14845209..14860488, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (14876697..14891976, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger homeobox 3a Neighboring gene MTSS I-BAR domain containing 2a Neighboring gene selenoprotein O1 Neighboring gene TraB domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Minor class splicing shapes the zebrafish transcriptome during development. Markmiller S, et al. Proc Natl Acad Sci U S A, 2014 Feb 25. PMID 24516132, Free PMC Article
    2. Characterization and expression patterns of the MAPK family in zebrafish. Krens SF, et al. Gene Expr Patterns, 2006 Oct. PMID 16774848
    3. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Lyche JL, et al. Aquat Toxicol, 2011 Apr. PMID 21356182
    4. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. Lyche JL, et al. J Toxicol Environ Health A, 2010. PMID 20526952
    5. In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation. Keightley MC, et al. FEBS Lett, 2013 Jul 11. PMID 23714367, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101695

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 12
    Names
    MAP kinase 12
    MAPK 12
    extracellular signal-regulated kinase 6
    p38-gamma
    stress-activated protein kinase 3
    NP_571482.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131407.1 → NP_571482.1  mitogen-activated protein kinase 12

      See identical proteins and their annotated locations for NP_571482.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085415
      UniProtKB/Swiss-Prot
      O42376
      UniProtKB/TrEMBL
      Q5U3S2
      Related
      ENSDARP00000011298.8, ENSDART00000018502.9
      Conserved Domains (2) summary
      smart00220
      Location:25 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9 → 351
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      14845209..14860488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O42376.1 GenPept UniProtKB/Swiss-Prot:O42376

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