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    aifm1 apoptosis inducing factor mitochondrion associated 1 [ Danio rerio (zebrafish) ]

    Gene ID: 373125, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aifm1provided by ZNC
    Official Full Name
    apoptosis inducing factor mitochondrion associated 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-11
    See related
    Ensembl:ENSDARG00000058088 AllianceGenome:ZFIN:ZDB-GENE-030826-11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    AIF; pdcd8; zgc:91994
    Summary
    Predicted to enable FAD binding activity and NAD(P)H oxidase H2O2-forming activity. Predicted to be involved in apoptotic process and mitochondrial respiratory chain complex assembly. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; hatching gland; musculature system; and polster. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aifm1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22550614..22573702, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22046814..22069932, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A Neighboring gene glycine receptor, alpha 4b Neighboring gene tumor necrosis factor (ligand) superfamily, member 10 like 4 Neighboring gene caspase 22, apoptosis-related cysteine peptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish. Zhou T, et al. Int J Nanomedicine, 2016. PMID 27980407, Free PMC Article
    2. Copper induced upregulation of apoptosis related genes in zebrafish (Danio rerio) gill. Luzio A, et al. Aquat Toxicol, 2013 Mar 15. PMID 23314331
    3. Apoptosis-related genes induced in response to ketamine during early life stages of zebrafish. Félix LM, et al. Toxicol Lett, 2017 Sep 5. PMID 28716577
    4. MS-222 induces biochemical and transcriptional changes related to oxidative stress, cell proliferation and apoptosis in zebrafish embryos. Félix LM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2020 Nov. PMID 32585370
    5. Dispersible MoS(2) micro-sheets induced a proinflammatory response and apoptosis in the gills and liver of adult zebrafish. Yu Y, et al. RSC Adv, 2018 May 14. PMID 35542100, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-inducing factor 1, mitochondrial
    Names
    programmed cell death 8 (apoptosis-inducing factor)
    NP_956396.2
    XP_005165182.1
    XP_005165184.1
    XP_009299566.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200102.2 → NP_956396.2  apoptosis-inducing factor 1, mitochondrial

      See identical proteins and their annotated locations for NP_956396.2

      Status: PROVISIONAL

      Source sequence(s)
      BC084689
      UniProtKB/TrEMBL
      Q5XFY2
      Related
      ENSDARP00000075326.4, ENSDART00000080882.6
      Conserved Domains (3) summary
      pfam00070
      Location:304 → 388
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:139 → 449
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:467 → 593
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      22550614..22573702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165127.4 → XP_005165184.1  apoptosis-inducing factor 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCF4
      Conserved Domains (3) summary
      pfam00070
      Location:431 → 515
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:266 → 576
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:594 → 720
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

    2. XM_009301291.3 → XP_009299566.1  apoptosis-inducing factor 1, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8M3AS24
      Conserved Domains (3) summary
      pfam00070
      Location:312 → 396
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:147 → 457
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:475 → 601
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

    3. XM_005165125.4 → XP_005165182.1  apoptosis-inducing factor 1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCB6
      Related
      ENSDARP00000120028.1, ENSDART00000131889.3
      Conserved Domains (4) summary
      pfam00070
      Location:439 → 523
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:274 → 584
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:602 → 728
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
      pfam14962
      Location:56 → 203
      AIF-MLS; Mitochondria Localization Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394573.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      65676..88735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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