ttk ttk protein kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ttkprovided by ZNC
Official Full Name: ttk protein kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030123-1
See related: Ensembl:ENSDARG00000041361 AllianceGenome:ZFIN:ZDB-GENE-030123-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ncp; mps1
Summary: Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in negative regulation of exit from mitosis and tissue regeneration. Acts upstream of or within anatomical structure homeostasis; fin regeneration; and meiotic chromosome segregation. Predicted to be active in kinetochore; nucleus; and spindle. Is expressed in caudal fin and proliferative region. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (5110455..5143134, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (5210829..5243498, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the proximal blastema comprises an essential subpopulation of the fin regenerate defined by the induction and function of Mps1
Title: Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration.
Mps1 is a critical regulator of chromosome number in zebrafish
Title: Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein kinase Ttk

Names: mitotic checkpoint serine/threonine-protein kinase Mps1; monopolar spindle 1; monopolar spindle protein 1; nightcap; protein nightcap

NP_778207.1

EC 2.7.12.1

XP_005157890.1

EC 2.7.12.1

XP_005157891.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175042.2 → NP_778207.1 dual specificity protein kinase Ttk

See identical proteins and their annotated locations for NP_778207.1

Status: PROVISIONAL

Source sequence(s)

AF488735

UniProtKB/Swiss-Prot

Q7T2A4, Q8AYG3

Related

ENSDARP00000121369.1, ENSDART00000131876.2

Conserved Domains (2) summary

cd14131
Location:652 → 917

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

pfam00069
Location:656 → 917

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

5110455..5143134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157834.4 → XP_005157891.1 dual specificity protein kinase Ttk isoform X1

UniProtKB/Swiss-Prot

Q7T2A4, Q8AYG3

UniProtKB/TrEMBL

A0A8M2B447, F1R3H9

Related

ENSDARP00000060629.6, ENSDART00000060630.8

Conserved Domains (2) summary

cd14131
Location:651 → 916

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

pfam00069
Location:655 → 916

Pkinase; Protein kinase domain
XM_005157833.4 → XP_005157890.1 dual specificity protein kinase Ttk isoform X2

UniProtKB/Swiss-Prot

Q7T2A4, Q8AYG3

UniProtKB/TrEMBL

A0A8M2B4P6

Conserved Domains (2) summary

cd14131
Location:652 → 917

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

pfam00069
Location:656 → 917

Pkinase; Protein kinase domain