Rcor1 REST corepressor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcor1provided by MGI
Official Full Name: REST corepressor 1provided by MGI
Primary source: MGI:MGI:106340
See related: Ensembl:ENSMUSG00000037896 AllianceGenome:MGI:106340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rocr1; D12Wsu95e; mKIAA0071; 5730409O11; 6720480E22Rik
Summary: Enables chromatin binding activity; enzyme binding activity; and transcription corepressor activity. Involved in erythrocyte differentiation; negative regulation of gene expression; and positive regulation of megakaryocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be part of DNA repair complex; histone deacetylase complex; and transcription repressor complex. Is expressed in several structures, including brain; early embryo; extraembryonic component; liver; and nose. Orthologous to human RCOR1 (REST corepressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 9.7), limb E14.5 (RPKM 9.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 60.93 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (111005801..111082336)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (111039367..111115902)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
Title: Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development.
Title: REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.
In mature erythroid cells, a strong upsurge in Rcor3 and a sharp decline in Rcor1 levels counteract LSD1/Rcor1/2-mediated differentiation.
Title: Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation.
Rcor1 promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
Title: Corepressor Rcor1 is essential for murine erythropoiesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Wsu95e (e-PCR), detects polymorphism
- UniSTS:141864

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

NoName (e-PCR)
- UniSTS:532325

Rcor1 (e-PCR), detects polymorphism
- UniSTS:532325

NoName (e-PCR)
- UniSTS:236961

BE688105 (e-PCR)
- UniSTS:208873

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of megakaryocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA repair complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: REST corepressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198023.3 → NP_932140.2 REST corepressor 1

Status: VALIDATED

Source sequence(s)

AC122023, AC153152

Consensus CDS

CCDS49179.2

UniProtKB/Swiss-Prot

K3W4P9, Q3V092, Q8BK28, Q8CFE3, Q8CHI2

Related

ENSMUSP00000082034.8, ENSMUST00000084968.14

Conserved Domains (3) summary

pfam00249
Location:379 → 422

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:99 → 152

ELM2; ELM2 domain

cl21498
Location:188 → 232

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...