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    Lpgat1 lysophosphatidylglycerol acyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 226856, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lpgat1provided by MGI
    Official Full Name
    lysophosphatidylglycerol acyltransferase 1provided by MGI
    Primary source
    MGI:MGI:2446186
    See related
    Ensembl:ENSMUSG00000026623 AllianceGenome:MGI:2446186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPLAT7
    Summary
    Enables 2-acylglycerol O-acyltransferase activity; 2-acylglycerophosphocholine O-acyltransferase activity; and lysophosphatidylethanolamine acyltransferase activity. Involved in phosphatidylethanolamine acyl-chain remodeling and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in nervous system; nose; respiratory system; salivary gland; and urinary system. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 21.4), genital fat pad adult (RPKM 19.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lpgat1 in Genome Data Viewer
    Location:
    1 H6; 1 96.78 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191449682..191516367)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191717554..191784255)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene denticleless E3 ubiquitin protein ligase Neighboring gene STARR-positive B cell enhancer ABC_E803 Neighboring gene STARR-positive B cell enhancer ABC_E1579 Neighboring gene STARR-positive B cell enhancer mm9_chr1:193423192-193423493 Neighboring gene integrator complex subunit 7 Neighboring gene STARR-seq mESC enhancer starr_03434 Neighboring gene predicted gene, 39741 Neighboring gene predicted gene, 22446 Neighboring gene predicted gene, 26203 Neighboring gene predicted gene, 20203 Neighboring gene STARR-positive B cell enhancer ABC_E1580 Neighboring gene STARR-positive B cell enhancer ABC_E4409 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport. Sun H, et al. Cell Rep, 2023 Nov 28. PMID 37917582, Free PMC Article
    2. LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling. Xu Y, et al. J Biol Chem, 2022 Mar. PMID 35131264, Free PMC Article
    3. Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase. Kawana H, et al. J Lipid Res, 2022 Oct. PMID 36049524, Free PMC Article
    4. Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion. Hiramine Y, et al. J Lipid Res, 2010 Jun. PMID 20018982, Free PMC Article
    5. LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles. Sato T, et al. J Biol Chem, 2023 Jul. PMID 37217003, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport.
      Title: LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport.
    2. LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles.
      Title: LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles.
    3. Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase.
      Title: Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase.
    4. LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling.
      Title: LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling.
    5. LPGAT1, a newly identified MGAT enzyme, plays a significant role in hepatic triacylglycerol synthesis and secretion in db/db mice.
      Title: Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0205, MGC18768

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-acylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-acylglycerophosphocholine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidylethanolamine acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophospholipid acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA:lysophosphatidylglycerol acyltransferase 1
    Names
    2-acylglycerophosphocholine O-acyltransferase
    acyl-CoA:monoacylglycerol acyltransferase LPGAT1
    lysophospholipid acyltransferase 7
    stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase
    NP_001128301.1
    NP_001408072.1
    NP_001408073.1
    NP_001408074.1
    NP_001408075.1
    NP_758470.1
    XP_006497220.1
    XP_036020142.1
    XP_036020144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134829.2 → NP_001128301.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_001128301.1

      Status: VALIDATED

      Source sequence(s)
      AC157810
      Consensus CDS
      CCDS48488.1
      UniProtKB/TrEMBL
      E9QL80, Q6A0A4
      Related
      ENSMUSP00000106480.2, ENSMUST00000110856.8
      Conserved Domains (2) summary
      cd07990
      Location:108 → 324
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:313 → 382
      Acyltransf_C; Acyltransferase C-terminus

    2. NM_001421143.1 → NP_001408072.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157810
      UniProtKB/TrEMBL
      E9QL80

    3. NM_001421144.1 → NP_001408073.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157810
      UniProtKB/Swiss-Prot
      Q91YX5

    4. NM_001421145.1 → NP_001408074.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157810
      UniProtKB/Swiss-Prot
      Q91YX5

    5. NM_001421146.1 → NP_001408075.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157810
      UniProtKB/Swiss-Prot
      Q91YX5

    6. NM_172266.4 → NP_758470.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_758470.1

      Status: VALIDATED

      Source sequence(s)
      AC157810
      Consensus CDS
      CCDS15622.1
      UniProtKB/Swiss-Prot
      Q91YX5
      UniProtKB/TrEMBL
      Q6A0A4
      Related
      ENSMUSP00000106479.2, ENSMUST00000110855.8
      Conserved Domains (2) summary
      cd07990
      Location:69 → 285
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:274 → 329
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      191449682..191516367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164249.1 → XP_036020142.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2

      Conserved Domains (2) summary
      cd07990
      Location:108 → 324
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:313 → 360
      Acyltransf_C; Acyltransferase C-terminus

    2. XM_036164251.1 → XP_036020144.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X4

      Conserved Domains (2) summary
      cd07990
      Location:69 → 285
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:274 → 321
      Acyltransf_C; Acyltransferase C-terminus

    3. XM_006497157.5 → XP_006497220.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X5

      UniProtKB/TrEMBL
      Q8R1E1
      Conserved Domains (2) summary
      cd07990
      Location:2 → 207
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:196 → 265
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YX5.1 GenPept UniProtKB/Swiss-Prot:Q91YX5

    Gene LinkOut

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