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    LPX1 triglyceride lipase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854251, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LPX1
    Official Full Name
    triglyceride lipase
    Primary source
    SGD:S000005610
    Locus tag
    YOR084W
    See related
    AllianceGenome:SGD:S000005610; FungiDB:YOR084W; VEuPathDB:YOR084W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables triacylglycerol lipase activity. Involved in triglyceride catabolic process. Located in peroxisomal matrix. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See LPX1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (480587..481750)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene triacylglycerol lipase Neighboring gene transcriptional repressor WHI5 Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 Neighboring gene tricalbin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lpx1p is a peroxisomal lipase required for normal peroxisome morphology. Thoms S, et al. FEBS J, 2008 Feb. PMID 18199283
    2. The unusual extended C-terminal helix of the peroxisomal α/β-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization. Thoms S, et al. J Struct Biol, 2011 Sep. PMID 21741480
    3. Screening for hydrolytic enzymes reveals Ayr1p as a novel triacylglycerol lipase in Saccharomyces cerevisiae. Ploier B, et al. J Biol Chem, 2013 Dec 13. PMID 24187129, Free PMC Article
    4. The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets. Thoms S, et al. Eukaryot Cell, 2011 Jun. PMID 21478430, Free PMC Article
    5. Transcriptome profiling to identify genes involved in peroxisome assembly and function. Smith JJ, et al. J Cell Biol, 2002 Jul 22. PMID 12135984, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    triglyceride lipase
    NP_014727.1
    • Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      480587..481750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183503.1 → NP_014727.1  TPA: triglyceride lipase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2E6, Q12405
      UniProtKB/TrEMBL
      A6ZNT5, B3LJD2, C7GT32, C8ZI46, G2WMW1, N1P322
      Conserved Domains (1) summary
      COG0596
      Location:55 → 337
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12405.1

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