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    RKM4 ribosomal lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851844, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RKM4
    Official Full Name
    ribosomal lysine N-methyltransferase
    Primary source
    SGD:S000002665
    Locus tag
    YDR257C
    See related
    AllianceGenome:SGD:S000002665; FungiDB:YDR257C; VEuPathDB:YDR257C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RMS1; SET7
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine monomethylation. Located in nucleus. Orthologous to human SETD6 (SET domain containing 6, protein lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RKM4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (969990..971474, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase RMD5 Neighboring gene catalase A Neighboring gene chaperone ATPase HSP78 Neighboring gene Yap6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Briggs SD, et al. Genes Dev, 2001 Dec 15. PMID 11751634, Free PMC Article
    2. The complexity of the interaction between RAD52 and SRS2. Kaytor MD, et al. Genetics, 1995 Aug. PMID 7498783, Free PMC Article
    3. A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast. Porras-Yakushi TR, et al. J Biol Chem, 2005 Oct 14. PMID 16096273
    4. Characterization of Protein Methyltransferases Rkm1, Rkm4, Efm4, Efm7, Set5 and Hmt1 Reveals Extensive Post-Translational Modification. Winter DL, et al. J Mol Biol, 2018 Jan 5. PMID 29183786
    5. Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab. Webb KJ, et al. J Biol Chem, 2008 Dec 19. PMID 18957409, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine monomethylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine monomethylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-lysine monomethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal lysine N-methyltransferase
    NP_010543.1
    • Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      969990..971474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180565.1 → NP_010543.1  TPA: ribosomal lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSN7, Q07015, Q12504
      UniProtKB/TrEMBL
      B3LG33, C7GTJ2, C8Z5G9, N1P6Q0
      Conserved Domains (1) summary
      cd19178
      Location:21 → 281
      SET_SETD6; SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12504.1

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