Hnrnpc heterogeneous nuclear ribonucleoprotein C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpcprovided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein Cprovided by MGI
Primary source: MGI:MGI:107795
See related: Ensembl:ENSMUSG00000060373 AllianceGenome:MGI:107795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpc; Hnrpc1; Hnrpc2; hnRNPC1; hnRNPC2; hnrnp-C; D14Wsu171e
Summary: Enables mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of nucleobase-containing compound metabolic process. Located in pronucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 123.0), CNS E14 (RPKM 61.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 26.79 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (52310834..52341462, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (52073377..52104039, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.
Title: N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.
hnRNPC induces isoform shifts in miR-21-5p leading to cancer development.
Title: hnRNPC induces isoform shifts in miR-21-5p leading to cancer development.
The data show that hnRNPC1 may be involved in the internalization of miR-30d inside exosomes.
Title: Heterogeneous nuclear ribonucleoprotein C1 may control miR-30d levels in endometrial exosomes affecting early embryo implantation.
APP levels then decrease progressively as a function of age in close relationship with the gradual normalization of FMRP and hnRNP C levels.
Title: Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease.
hnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).
Title: Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.
Neither hnRNP-C nor FMRP is required for cyclic AMP to stimulate APP and Amyloid beta production.
Title: Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism.
our results reveal a new function of the splicing factor hnRNP C in the maturation of dendritic cells that involves regulating the expression of NF-kappaB p65 and its downstream targets CD80 and CD40.
Title: The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells.
Data suggest that increased levels of hnRNP C1/C2 may modulate XIAP translation by interacting with the XIAP-IRES, and may foster synthesis of XIAP as a protective pathway by which neurons try to counteract the initial deleterious effects of apoptosis.
Title: Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis.
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
Title: Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC85779P1 (e-PCR)
- UniSTS:273490

NoName (e-PCR)
- UniSTS:237180

RH133947 (e-PCR)
- UniSTS:217230

Hnrpc (e-PCR), detects polymorphism
- UniSTS:479120

D14Wsu171e (e-PCR), detects polymorphism
- UniSTS:142000

PMC137566P2 (e-PCR)
- UniSTS:270843

Hnrpc (e-PCR), detects polymorphism
- UniSTS:143359

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables deaminase binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mRNA modification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasmic periphery of the nuclear pore complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoproteins C1/C2

Names: heterogeneous nuclear ribonucleoprotein C1; heterogeneous nuclear ribonucleoprotein C2; heterogeneous ribonucleoprotein C1/C2; hnRNP C1 / hnRNP C2; hnRNP C1/C2; hnRNP C2; snoRNA MBI-122

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170981.3 → NP_001164452.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

See identical proteins and their annotated locations for NP_001164452.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2, 3 and 13 encode the same isoform (2).

Source sequence(s)

AC157572

Consensus CDS

CCDS88662.1

UniProtKB/TrEMBL

Q3U6P5

Related

ENSMUSP00000154757.2, ENSMUST00000227242.2

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001170982.3 → NP_001164453.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

See identical proteins and their annotated locations for NP_001164453.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2, 3 and 13 encode the same isoform (2).

Source sequence(s)

AC157572

Consensus CDS

CCDS88662.1

UniProtKB/TrEMBL

Q3U6P5

Related

ENSMUSP00000154737.2, ENSMUST00000227536.2

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001170983.3 → NP_001164454.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

See identical proteins and their annotated locations for NP_001164454.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. Variants 4, 14, 15 and 16 encode the same isoform (3).

Source sequence(s)

AC157572

Consensus CDS

CCDS88661.1

UniProtKB/Swiss-Prot

Q9Z204

Related

ENSMUSP00000154166.2, ENSMUST00000228748.2

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001170984.3 → NP_001164455.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

See identical proteins and their annotated locations for NP_001164455.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. Variants 5, 17 and 18 encode the same isoform (4).

Source sequence(s)

AC157572

Consensus CDS

CCDS88660.1

UniProtKB/TrEMBL

Q3U6P5

Related

ENSMUSP00000154238.2, ENSMUST00000227458.2

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360172.2 → NP_001347101.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS36917.1

UniProtKB/Swiss-Prot

Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360173.2 → NP_001347102.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS36917.1

UniProtKB/Swiss-Prot

Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360174.2 → NP_001347103.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88659.1

Related

ENSMUSP00000154212.2, ENSMUST00000228198.2

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360175.2 → NP_001347104.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88659.1

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360176.2 → NP_001347105.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

Status: VALIDATED

Source sequence(s)

AC157572

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360177.2 → NP_001347106.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

Status: VALIDATED

Source sequence(s)

AC157572

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360178.2 → NP_001347107.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

Status: VALIDATED

Source sequence(s)

AC157572

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360179.2 → NP_001347108.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88662.1

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360180.2 → NP_001347109.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88661.1

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360181.2 → NP_001347110.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88661.1

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360182.2 → NP_001347111.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88661.1

Related

ENSMUSP00000154619.2, ENSMUST00000228232.2

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360183.2 → NP_001347112.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88660.1

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001360184.2 → NP_001347113.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

Status: VALIDATED

Source sequence(s)

AC157572

Consensus CDS

CCDS88660.1

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001424475.1 → NP_001411404.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

Status: VALIDATED

Source sequence(s)

AC157572
NM_001424476.1 → NP_001411405.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

Status: VALIDATED

Source sequence(s)

AC157572
NM_001424477.1 → NP_001411406.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

Status: VALIDATED

Source sequence(s)

AC157572
NM_001424478.1 → NP_001411407.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

Status: VALIDATED

Source sequence(s)

AC157572

UniProtKB/Swiss-Prot

Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
NM_001424479.1 → NP_001411408.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

Status: VALIDATED

Source sequence(s)

AC157572
NM_001424480.1 → NP_001411409.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

Status: VALIDATED

Source sequence(s)

AC157572
NM_001424481.1 → NP_001411410.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

Status: VALIDATED

Source sequence(s)

AC157572
NM_001424482.1 → NP_001411411.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

Status: VALIDATED

Source sequence(s)

AC157572
NM_016884.5 → NP_058580.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

See identical proteins and their annotated locations for NP_058580.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1, 6 and 7 encode the same isoform (1).

Source sequence(s)

AC157572

Consensus CDS

CCDS36917.1

UniProtKB/Swiss-Prot

Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204

UniProtKB/TrEMBL

Q3U6P5

Related

ENSMUSP00000107237.5, ENSMUST00000111610.12

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

52310834..52341462 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158467.1 → XP_036014360.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

UniProtKB/Swiss-Prot

Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204

UniProtKB/TrEMBL

Q3U6P5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)