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    queD 6-carboxy-5,6,7,8-tetrahydropterin synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945123, updated on 10-Oct-2024

    Summary

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    Official Symbol
    queD
    Official Full Name
    6-carboxy-5,6,7,8-tetrahydropterin synthase
    Primary source
    ECOCYC:G7431
    Locus tag
    b2765
    See related
    ASAP:ABE-0009068
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2760; sscR; ygcM
    Summary
    QueD was mistakenly identified as a 6-pyruvoyl tetrahydrobiopterin (PPH4) synthase (PTPS); the identity of the product was not confirmed (Woo, 2002). [More information is available at EcoGene: EG13120]. SscR has been demonstrated in vitro to be a working 6-pyruvoyl tetrahydropterin synthase . [More information is available at EcoCyc: G7431].
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    Genomic context

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    Sequence:
    NC_000913.3 (2892214..2892579)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sulfite reductase, hemoprotein subunit Neighboring gene sulfite reductase, flavoprotein subunit Neighboring gene putative oxidoreductase with FAD/NAD(P)-binding domain Neighboring gene putative 4Fe-4S cluster-containing protein Neighboring gene putative anti-terminator regulatory protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity. Seo KH, et al. Acta Crystallogr D Biol Crystallogr, 2014 May. PMID 24816091
    2. Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase. McCarty RM, et al. Biochemistry, 2009 Mar 24. PMID 19231875, Free PMC Article
    3. Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin. Woo HJ, et al. FEBS Lett, 2002 Jul 17. PMID 12123838
    4. Biosynthesis of the 7-deazaguanosine hypermodified nucleosides of transfer RNA. Iwata-Reuyl D. Bioorg Chem, 2003 Feb. PMID 12697167
    5. Identification of genes encoding tRNA modification enzymes by comparative genomics. de Crécy-Lagard V. Methods Enzymol, 2007. PMID 17673083, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. two aromatic residues in PTPS protein play an essential role in stabilizing the substrate and in the specific enzyme activity
      Title: Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity.
    2. QueD catalyzes the conversion of 7,8-dihydroneopterin triphosphate to 6-carboxy-5,6,7,8-tetrahydropterin.
      Title: Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 6-carboxy-5,6,7,8-tetrahydropterin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-carboxy-5,6,7,8-tetrahydropterin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 6-carboxy-5,6,7,8-tetrahydropterin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in queuosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within queuosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    6-carboxy-5,6,7,8-tetrahydropterin synthase
    NP_417245.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2892214..2892579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417245.1 6-carboxy-5,6,7,8-tetrahydropterin synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417245.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D6GUJ0, A0A0E2L1F3, A0A0H2Z218, A0A135PTA7, A0A192CB77, A0A1V2FPY3, A0A244BUC4, A0A3P5DUY0, A0A454A6V8, A0AAD2S1I7, A0AAN4H6H9, A0AAN4KUQ6, A0AAN5KEZ9, B7ML84, B7MZ58, B7N6Z9, B7UHH7, F4T492, S1P3U8
      Conserved Domains (1) summary
      cl00263
      Location:3 → 121
      TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...
    Nucleotide Protein
    Heading Accession and Version

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