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    nup93 nucleoporin 93 [ Danio rerio (zebrafish) ]

    Gene ID: 30172, updated on 27-Mar-2024

    Summary

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    Official Symbol
    nup93provided by ZNC
    Official Full Name
    nucleoporin 93provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-46
    See related
    Ensembl:ENSDARG00000003487 AllianceGenome:ZFIN:ZDB-GENE-990415-46
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dye
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore complex assembly; poly(A)+ mRNA export from nucleus; and protein import into nucleus. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in nuclear membrane and nuclear periphery. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See nup93 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17531496..17577984)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17542462..17588918)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene metallothionein 2 Neighboring gene microRNA 138 Neighboring gene solute carrier family 12 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Allende ML, et al. Genes Dev, 1996 Dec 15. PMID 8985183
    2. Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish. Teoh SL, et al. J Chem Neuroanat, 2015 Dec. PMID 26571427
    3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear periphery ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup93
    Names
    93 kDa nucleoporin
    dead eye protein
    nucleoporin Nup93

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130981.2 → NP_571056.2  nuclear pore complex protein Nup93

      See identical proteins and their annotated locations for NP_571056.2

      Status: PROVISIONAL

      Source sequence(s)
      BC044466
      UniProtKB/Swiss-Prot
      P79740, Q7ZU29, Q9DGQ8
      UniProtKB/TrEMBL
      B2GRL6
      Related
      ENSDARP00000013627.7, ENSDART00000025782.9
      Conserved Domains (2) summary
      pfam04097
      Location:220 → 804
      Nic96; Nup93/Nic96
      cl14813
      Location:4 → 127
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      17531496..17577984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293522.2 → XP_009291797.1  nuclear pore complex protein Nup93 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B2U6, Q1LV08
      Conserved Domains (2) summary
      pfam04097
      Location:220 → 804
      Nic96; Nup93/Nic96
      cl14813
      Location:4 → 127
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    2. XM_009293523.3 → XP_009291798.1  nuclear pore complex protein Nup93 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AKC1
      Conserved Domains (1) summary
      pfam04097
      Location:88 → 672
      Nic96; Nup93/Nic96

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395018.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      426111..458311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZU29.1 GenPept UniProtKB/Swiss-Prot:Q7ZU29

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