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    STRIP2 striatin interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 57464, updated on 14-Nov-2024

    Summary

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    Official Symbol
    STRIP2provided by HGNC
    Official Full Name
    striatin interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:22209
    See related
    Ensembl:ENSG00000128578 MIM:617919; AllianceGenome:HGNC:22209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM40B; FAR11B
    Summary
    Involved in cell migration; cytoskeleton organization; and regulation of cell shape. Located in cytosol. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 7.5), brain (RPKM 4.0) and 9 other tissues See more
    Orthologs
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    Genomic context

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    See STRIP2 in Genome Data Viewer
    Location:
    7q32.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (129434432..129488399)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (130747403..130801465)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129074273..129128240)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase like 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:129059227-129059428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18629 Neighboring gene RNA, U7 small nuclear 16 pseudogene Neighboring gene cell division cycle 26 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr7:129109680-129110219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18631 Neighboring gene RNA, U1 small nuclear 72, pseudogene Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129166309-129166810 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129173685-129174202 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129174203-129174720 Neighboring gene small lysine rich protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129201761-129202261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26632 Neighboring gene nuclear respiratory factor 1 Neighboring gene Sharpr-MPRA regulatory region 6855 Neighboring gene RNA, 5S ribosomal pseudogene 244

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. STRIP2, a member of the striatin-interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration. Qiu LM, et al. FEBS Open Bio, 2020 Mar. PMID 31901223, Free PMC Article
    2. STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K/AKT/mTOR/MYC signaling pathway. Pan J, et al. Genomics, 2024 Sep. PMID 39191354
    3. STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent. Zhang X, et al. J Exp Clin Cancer Res, 2023 Jan 13. PMID 36639675, Free PMC Article
    4. The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs. Suryavanshi N, et al. BMC Cell Biol, 2018 Dec 3. PMID 30509168, Free PMC Article
    5. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Eden M, et al. Nat Commun, 2016 Apr 28. PMID 27122098, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K/AKT/mTOR/MYC signaling pathway.
      Title: STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K/AKT/mTOR/MYC signaling pathway.
    2. STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.
      Title: STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.
    3. STRIP2, a member of the striatin-interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration.
      Title: STRIP2, a member of the striatin-interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration.
    4. These results demonstrate the importance of the FAM40 proteins for endothelial cell physiology, and suggest that they act as part of the CCM3-containing STRIPAK complex.
      Title: The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.
    5. Data indicate that a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel CaV1.2.
      Title: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
    6. this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage.
      Title: STRIPAK components determine mode of cancer cell migration and metastasis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    striatin-interacting protein 2
    Names
    FAR11 factor arrest 11 homolog B
    family with sequence similarity 40, member B
    homolog of yeast FAR11 protein 2
    protein FAM40B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134336.2 → NP_001127808.1  striatin-interacting protein 2 isoform b

      See identical proteins and their annotated locations for NP_001127808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC009244, BC019064, DA409007
      Consensus CDS
      CCDS47709.1
      UniProtKB/TrEMBL
      A8K2A0
      Related
      ENSP00000392393.2, ENST00000435494.2
      Conserved Domains (2) summary
      pfam07923
      Location:49 → 326
      N1221; N1221-like protein
      pfam11882
      Location:456 → 751
      DUF3402; Domain of unknown function (DUF3402)

    2. NM_020704.3 → NP_065755.1  striatin-interacting protein 2 isoform a

      See identical proteins and their annotated locations for NP_065755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB032996, AC009244, DA409007
      Consensus CDS
      CCDS34752.1
      UniProtKB/Swiss-Prot
      Q8WUZ4, Q9ULQ0
      UniProtKB/TrEMBL
      A8K2A0
      Related
      ENSP00000249344.2, ENST00000249344.7
      Conserved Domains (2) summary
      pfam07923
      Location:49 → 338
      N1221; N1221-like protein
      pfam11882
      Location:456 → 779
      DUF3402; Domain of unknown function (DUF3402)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      129434432..129488399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716069.4 → XP_006716132.1  striatin-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A8K2A0
      Conserved Domains (2) summary
      pfam07923
      Location:49 → 338
      N1221; N1221-like protein
      pfam11882
      Location:456 → 684
      DUF3402; Domain of unknown function (DUF3402)

    2. XM_017012470.2 → XP_016867959.1  striatin-interacting protein 2 isoform X2

      Conserved Domains (2) summary
      pfam07923
      Location:49 → 338
      N1221; N1221-like protein
      pfam11882
      Location:456 → 625
      DUF3402; Domain of unknown function (DUF3402)

    3. XM_047420656.1 → XP_047276612.1  striatin-interacting protein 2 isoform X5

    4. XM_011516435.2 → XP_011514737.1  striatin-interacting protein 2 isoform X6

      Conserved Domains (2) summary
      pfam07923
      Location:49 → 338
      N1221; N1221-like protein
      pfam11882
      Location:456 → 485
      DUF3402; Domain of unknown function (DUF3402)

    5. XM_011516432.2 → XP_011514734.1  striatin-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      A8K2A0
      Conserved Domains (2) summary
      pfam07923
      Location:1 → 177
      N1221; N1221-like protein
      pfam11882
      Location:295 → 618
      DUF3402; Domain of unknown function (DUF3402)

    6. XM_017012471.1 → XP_016867960.1  striatin-interacting protein 2 isoform X4

    7. XM_047420657.1 → XP_047276613.1  striatin-interacting protein 2 isoform X7

    RNA

    1. XR_927493.2 RNA Sequence

    2. XR_001744840.2 RNA Sequence

    3. XR_001744841.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      130747403..130801465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358707.1 → XP_054214682.1  striatin-interacting protein 2 isoform X1

    2. XM_054358708.1 → XP_054214683.1  striatin-interacting protein 2 isoform X2

    3. XM_054358711.1 → XP_054214686.1  striatin-interacting protein 2 isoform X5

    4. XM_054358712.1 → XP_054214687.1  striatin-interacting protein 2 isoform X6

    5. XM_054358709.1 → XP_054214684.1  striatin-interacting protein 2 isoform X3

    6. XM_054358710.1 → XP_054214685.1  striatin-interacting protein 2 isoform X4

    7. XM_054358713.1 → XP_054214688.1  striatin-interacting protein 2 isoform X7

    RNA

    1. XR_008487709.1 RNA Sequence

    2. XR_008487707.1 RNA Sequence

    3. XR_008487708.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULQ0.2 GenPept UniProtKB/Swiss-Prot:Q9ULQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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