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    sall1.L spalt-like transcription factor 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379679, updated on 4-Nov-2024

    Summary

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    Official Symbol
    sall1.L
    Official Full Name
    spalt-like transcription factor 1 L homeolog
    Primary source
    Xenbase:XB-GENE-866060
    Locus tag
    XELAEV_18022516mg
    See related
    EnsemblRapid:ENSXLAG00005017681 AllianceGenome:Xenbase:XB-GENE-866060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    tbs; sal1; sal-1; sall1; sall1b; znf794; sall1-a; sall1-b; sall1.S
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and metal ion binding activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in anatomical system and primary germ layer. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome; middle lobe syndrome; and renal Wilms' tumor. Orthologous to human SALL1 (spalt like transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sall1.L in Genome Data Viewer
    Location:
    chromosome: 4L
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (43185077..43204151)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (40703142..40714755)

    Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121403007 Neighboring gene uncharacterized LOC108714016 Neighboring gene CYLD lysine 63 deubiquitinase L homeolog Neighboring gene ARF like GTPase 2 binding protein L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. sall1 and sall4 repress pou5f3 family expression to allow neural patterning, differentiation, and morphogenesis in Xenopus laevis. Exner CRT, et al. Dev Biol, 2017 May 1. PMID 28322736
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that both sall1 and sall4 act to repress pou5f3 (oct4)family gene expression in the neural plate, thereby allowing vertebrate neural development to proceed.
      Title: sall1 and sall4 repress pou5f3 family expression to allow neural patterning, differentiation, and morphogenesis in Xenopus laevis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC68418

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spalt-like transcription factor 1 L homeolog
    Names
    sal-like 1 b
    spalt transcription factor Sall1
    spalt-like 1
    spalt-like transcription factor 1 S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086519.2 → NP_001079988.2  spalt-like transcription factor 1 L homeolog

      Status: VALIDATED

      Source sequence(s)
      JAGEVR010000047

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      43185077..43204151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041589143.1 → XP_041445077.1  spalt-like transcription factor 1 L homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1MTI3, Q9DDN5
      Related
      ENSXLAP00005052193.1, ENSXLAT00005053357.1
      Conserved Domains (3) summary
      smart00355
      Location:773 → 795
      ZnF_C2H2; zinc finger
      sd00017
      Location:715 → 735
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1010 → 1030
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_041589144.1 → XP_041445078.1  spalt-like transcription factor 1 L homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J1MUQ7, A0A974HNR4
      Conserved Domains (3) summary
      smart00355
      Location:733 → 755
      ZnF_C2H2; zinc finger
      sd00017
      Location:675 → 695
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:970 → 990
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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