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    capn5.S calpain 5 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 414629, updated on 4-Nov-2024

    Summary

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    Official Symbol
    capn5.S
    Official Full Name
    calpain 5 S homeolog
    Primary source
    Xenbase:XB-GENE-17346164
    Locus tag
    XELAEV_18016388mg
    See related
    EnsemblRapid:ENSXLAG00005000285 AllianceGenome:Xenbase:XB-GENE-17346164
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    htra3; ncl-3
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in neovascular inflammatory vitreoretinopathy. Orthologous to human CAPN5 (calpain 5). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See capn5.S in Genome Data Viewer
    Location:
    chromosome: 2S
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (163572952..163625803, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (154204220..154245845, complement)

    Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene RELT, TNF receptor S homeolog Neighboring gene Rho guanine nucleotide exchange factor 17 S homeolog Neighboring gene uncharacterized LOC121400728 Neighboring gene olfactory marker protein S homeolog Neighboring gene alkaline ceramidase 3 S homeolog Neighboring gene tsukushi, small leucine rich proteoglycan S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC81349

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC414629

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001091200.1 → NP_001084669.1  uncharacterized protein LOC414629

      See identical proteins and their annotated locations for NP_001084669.1

      Status: PREDICTED

      Source sequence(s)
      BC068792
      UniProtKB/TrEMBL
      A0A974DSV7, Q6NU10
      Related
      ENSXLAP00005000780.1, ENSXLAT00005000807.1
      Conserved Domains (3) summary
      cd04046
      Location:515 → 640
      C2_Calpain; C2 domain present in Calpain proteins
      pfam00648
      Location:27 → 341
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:354 → 493
      Calpain_III; Calpain large subunit, domain III

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      163572952..163625803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041583067.1 → XP_041439001.1  uncharacterized protein LOC414629 isoform X1

      UniProtKB/TrEMBL
      A0A1L8HB59, A0A974DKF5, A0A974DSV7
      Related
      ENSXLAP00005000783.1, ENSXLAT00005000810.1
      Conserved Domains (3) summary
      cd04046
      Location:515 → 640
      C2_Calpain; C2 domain present in Calpain proteins
      pfam00648
      Location:27 → 341
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:362 → 488
      Calpain_III; Calpain large subunit, domain III
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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