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    slc31a1 solute carrier family 31 member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 403028, updated on 2-Nov-2024

    Summary

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    Official Symbol
    slc31a1provided by ZNC
    Official Full Name
    solute carrier family 31 member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040415-3
    See related
    Ensembl:ENSDARG00000013961 AllianceGenome:ZFIN:ZDB-GENE-040415-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctr1; ctr-1; zgc:76839
    Summary
    Predicted to enable copper ion transmembrane transporter activity. Acts upstream of or within cellular response to estrogen stimulus; hypotonic salinity response; and response to copper ion. Predicted to be located in basolateral plasma membrane; late endosome membrane; and lateral plasma membrane. Is expressed in gill; gut; liver; locus coeruleus; and yolk syncytial layer. Orthologous to human SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc31a1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (57328535..57354915)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (56658318..56684698)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene fer (fps/fes related) tyrosine kinase Neighboring gene uncharacterized LOC137495640 Neighboring gene ATPase H+ transporting V1 subunit G1 Neighboring gene uncharacterized LOC137490175 Neighboring gene cell division cycle 26 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression pattern and essentiality of the high-affinity copper transporter 1 (ctr1) gene in zebrafish. Mackenzie NC, et al. Gene, 2004 Mar 17. PMID 15019990
    2. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Xiao T, et al. Nat Chem Biol, 2018 Jul. PMID 29867144, Free PMC Article
    3. Physiological response to a metal-contaminated invertebrate diet in zebrafish: importance of metal speciation and regulation of metal transport pathways. Boyle D, et al. Aquat Toxicol, 2011 Sep. PMID 21684238
    4. Exposure to copper nanoparticles causes gill injury and acute lethality in zebrafish (Danio rerio). Griffitt RJ, et al. Environ Sci Technol, 2007 Dec 1. PMID 18186356
    5. Water chemistry alters gene expression and physiological end points of chronic waterborne copper exposure in zebrafish, Danio rerio. Craig PM, et al. Environ Sci Technol, 2010 Mar 15. PMID 20163087

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish ctr1 or atox1 overexpression increased Cu accumulation in zebrafish liver cell line ZFL.
      Title: Functional characterization of copper transporters zCtr1, zAtox1, zAtp7a and zAtp7b in zebrafish liver cell line ZFL.
    2. Studies show that zebrafish ctr1 is an essential gene for development.
      Title: Cloning, expression pattern and essentiality of the high-affinity copper transporter 1 (ctr1) gene in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within copper ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within copper ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within copper ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within hypotonic salinity response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to copper ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    high affinity copper uptake protein 1
    Names
    high affinity copper uptake protein
    solute carrier family 31 (copper transporter), member 1
    solute carrier family 31 (copper transporters), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320405.1 → NP_001307334.1  high affinity copper uptake protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CF996108, FP017233
      UniProtKB/TrEMBL
      A0A8M1P2F2, F1QKH1
      Related
      ENSDARP00000123985.1, ENSDART00000149646.3
      Conserved Domains (1) summary
      pfam04145
      Location:41 → 173
      Ctr; Ctr copper transporter family

    2. NM_205717.3 → NP_991280.2  high affinity copper uptake protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      FP017233
      UniProtKB/TrEMBL
      A0A8M1P2F2, F1QKH1
      Related
      ENSDARP00000015824.8, ENSDART00000012586.9
      Conserved Domains (1) summary
      pfam04145
      Location:41 → 173
      Ctr; Ctr copper transporter family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      57328535..57354915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394616.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      133036..159451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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