igf1rb insulin-like growth factor 1b receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf1rbprovided by ZNC
Official Full Name: insulin-like growth factor 1b receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020503-2
See related: Ensembl:ENSDARG00000034434 AllianceGenome:ZFIN:ZDB-GENE-020503-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IGF-IR; IGF-IRb; wu:fb03h06
Summary: Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Acts upstream of or within several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; eye; heart; musculature system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (15447177..15603094)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (15198890..15354807)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of IGFR1 signaling results in an abnormal appearance of gonadotropin- releasing hormone (GnRH)3 neurons outside of the olfactory bulb region, although it does not change the locations of other olfactory neurons.
Title: Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish.
results provide novel insight into the cellular function of IGF1 receptor and show IGF1R signaling does not function as an anteriorizing signal but regulates embryonic growth and development by promoting cell survival and cell cycle progression
Title: Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression.
Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival.
Title: Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival.
Duplicated zebrafish ig f1r genes (ig f1ra and ig f1rb)play largely overlapping but not identical functional roles in early development.
Title: Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
enables insulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor binding	IPI Inferred from Physical Interaction more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chordate embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin-like growth factor 1b receptor

NP_694501.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152969.1 → NP_694501.1 insulin-like growth factor 1b receptor precursor

See identical proteins and their annotated locations for NP_694501.1

Status: PROVISIONAL

Source sequence(s)

AF400276

UniProtKB/TrEMBL

A0A8M1PBN6

Related

ENSDARP00000046541.4, ENSDART00000046542.7

Conserved Domains (6) summary

cd05032
Location:980 → 1255

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:823 → 910

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:219 → 265

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:176 → 320

Furin-like; Furin-like cysteine rich region

pfam01030
Location:338 → 449

Recep_L_domain; Receptor L domain

pfam07714
Location:987 → 1253

Pkinase_Tyr; Protein tyrosine kinase