cyp2aa4 cytochrome P450, family 2, subfamily AA, polypeptide 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp2aa4provided by ZNC
Official Full Name: cytochrome P450, family 2, subfamily AA, polypeptide 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-72
See related: Ensembl:ENSDARG00000098803 AllianceGenome:ZFIN:ZDB-GENE-040625-72
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp2; zgc:86915
Summary: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in integument and liver. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: chromosome: 23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (42362337..42378392)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (42396841..42413002)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2AA4; cytochrome P450, family 2, subfamily AA, polypeptide 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002092.3 → NP_001002092.2 cytochrome P450 2AA4

Status: VALIDATED

Source sequence(s)

FP015919

UniProtKB/TrEMBL

Q6IQ77

Related

ENSDARP00000134379.1, ENSDART00000164249.2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

42362337..42378392

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017353539.2 → XP_017209028.1 cytochrome P450, family 2, subfamily AA, polypeptide 4 isoform X2

UniProtKB/TrEMBL

A0A8M6YV80, Q6IQ77
XM_009297112.3 → XP_009295387.1 cytochrome P450, family 2, subfamily AA, polypeptide 4 isoform X1

UniProtKB/TrEMBL

A0A8M3AYT4

Conserved Domains (1) summary

pfam00067
Location:7 → 330

p450; Cytochrome P450