spg7 SPG7 matrix AAA peptidase subunit, paraplegin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spg7provided by ZNC
Official Full Name: SPG7 matrix AAA peptidase subunit, parapleginprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5391
See related: Ensembl:ENSDARG00000068187 AllianceGenome:ZFIN:ZDB-GENE-030131-5391
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fd15f08; wu:fd15f08
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (56152257..56180706, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (55850650..55879297, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd15f08.x1 (e-PCR)
- UniSTS:204200

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of m-AAA complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paraplegin; mitochondrial inner membrane m-AAA protease component paraplegin

Names: spastic paraplegia 7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

56152257..56180706 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001923083.7 → XP_001923118.1 mitochondrial inner membrane m-AAA protease component paraplegin isoform X1

UniProtKB/TrEMBL

A0A8M1QHU6, E7F2S4

Related

ENSDARP00000089209.4, ENSDART00000098438.5

Conserved Domains (4) summary

TIGR01241
Location:257 → 738

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam00004
Location:337 → 470

AAA; ATPase family associated with various cellular activities (AAA)

pfam01434
Location:552 → 736

Peptidase_M41; Peptidase family M41

pfam06480
Location:136 → 233

FtsH_ext; FtsH Extracellular

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394712.1 Reference GRCz11 ALT_DRER_TU_1

Range

628305..650306 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021472024.2 → XP_021327699.1 mitochondrial inner membrane m-AAA protease component paraplegin isoform X2

UniProtKB/TrEMBL

A0A8M9PS13

Conserved Domains (2) summary

pfam06480
Location:99 → 196

FtsH_ext; FtsH Extracellular

cl27568
Location:220 → 701

TIP49; TIP49 C-terminus

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395269.1 Reference GRCz11 ALT_DRER_TU_2

Range

419428..441439 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474143.1 → XP_021329818.1 mitochondrial inner membrane m-AAA protease component paraplegin isoform X3

UniProtKB/TrEMBL

A0A8M9PS13

Conserved Domains (2) summary

pfam06480
Location:99 → 196

FtsH_ext; FtsH Extracellular

cl27568
Location:220 → 701

TIP49; TIP49 C-terminus