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    GPR151 G protein-coupled receptor 151 [ Homo sapiens (human) ]

    Gene ID: 134391, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR151provided by HGNC
    Official Full Name
    G protein-coupled receptor 151provided by HGNC
    Primary source
    HGNC:HGNC:23624
    See related
    Ensembl:ENSG00000173250 MIM:618487; AllianceGenome:HGNC:23624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPCR; PGR7; GALR4; GALRL; GPCR-2037
    Summary
    This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
    Orthologs
    mouse all
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    Genomic context

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    See GPR151 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (146513144..146516190, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (147049016..147052062, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145892707..145895753, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378213 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81818 Neighboring gene Sharpr-MPRA regulatory region 15640 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145826559-145827266 Neighboring gene transcription elongation regulator 1 Neighboring gene MPRA-validated peak5524 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:145920194-145920694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:145939738-145940393 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145989281-145989921 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene RNA, 7SL, cytoplasmic 791, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orphan G-protein-coupled receptors and natural ligand discovery. Howard AD, et al. Trends Pharmacol Sci, 2001 Mar. PMID 11239576
    2. Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets. Tang XL, et al. Acta Pharmacol Sin, 2012 Mar. PMID 22367282, Free PMC Article
    3. Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index. Gurtan A, et al. PLoS Genet, 2022 Apr. PMID 35381001, Free PMC Article
    4. The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake. Antolin-Fontes B, et al. Proc Natl Acad Sci U S A, 2020 Mar 10. PMID 32098843, Free PMC Article
    5. Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain. Holmes FE, et al. Mol Cell Neurosci, 2017 Jan. PMID 27913310, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
      Title: Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
    2. Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.
      Title: Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.
    3. These data identify GPR151 as a critical modulator of habenular function that controls nicotine addiction vulnerability
      Title: The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake.
    4. Northern blot analysis reveals expression of galanin-receptor like (GalRL) in the central nervous system with minor levels in peripheral organs and tissues, such as testis, liver, kidney and stomach.
      Title: Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cholinergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 151
    Names
    G-protein coupled receptor PGR7
    galanin receptor 4
    galanin-receptor-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194251.3 → NP_919227.2  G-protein coupled receptor 151

      See identical proteins and their annotated locations for NP_919227.2

      Status: VALIDATED

      Source sequence(s)
      AC011375
      Consensus CDS
      CCDS34266.1
      UniProtKB/Swiss-Prot
      Q86SN8, Q8NGV2, Q8TDV0
      Related
      ENSP00000308733.2, ENST00000311104.3
      Conserved Domains (1) summary
      cd15002
      Location:38 → 317
      7tmA_GPR151; G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      146513144..146516190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      147049016..147052062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDV0.1 GenPept UniProtKB/Swiss-Prot:Q8TDV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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