SPAG5 sperm associated antigen 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPAG5provided by HGNC
Official Full Name: sperm associated antigen 5provided by HGNC
Primary source: HGNC:HGNC:13452
See related: Ensembl:ENSG00000076382 MIM:615562; AllianceGenome:HGNC:13452
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAP126; DEEPEST; hMAP126
Summary: This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 49.5), bone marrow (RPKM 14.3) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q11.2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (28577574..28599025, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (29520199..29541650, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (26904592..26926043, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE[-/-] mice.
Title: SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
SPAG5 promotes the proliferation, migration, invasion, and epithelial-mesenchymal transformation of colorectal cancer cells by activating the PI3K/AKT signaling pathway.
Title: SPAG5 promotes the proliferation, migration, invasion, and epithelial-mesenchymal transformation of colorectal cancer cells by activating the PI3K/AKT signaling pathway.
SPAG5, the upstream protein of Wnt and the target of curcumin, inhibits hepatocellular carcinoma.
Title: SPAG5, the upstream protein of Wnt and the target of curcumin, inhibits hepatocellular carcinoma.
SPAG5 as a novel biomarker and potential therapeutic target via regulating AKT pathway in multiple myeloma.
Title: SPAG5 as a novel biomarker and potential therapeutic target via regulating AKT pathway in multiple myeloma.
Downregulation of sperm-associated antigen 5 inhibits melanoma progression by regulating forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling.
Title: Downregulation of sperm-associated antigen 5 inhibits melanoma progression by regulating forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling.
CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis.
Title: CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis.
MiR-133a-3p attenuates resistance of non-small cell lung cancer cells to gefitinib by targeting SPAG5.
Title: MiR-133a-3p attenuates resistance of non-small cell lung cancer cells to gefitinib by targeting SPAG5.
MicroRNA-367-3p overexpression represses the proliferation and invasion of cervical cancer cells through downregulation of SPAG5-mediated Wnt/beta-catenin signalling.
Title: MicroRNA-367-3p overexpression represses the proliferation and invasion of cervical cancer cells through downregulation of SPAG5-mediated Wnt/β-catenin signalling.
Expression, immune infiltration and clinical significance of SPAG5 in hepatocellular carcinoma: A gene expression-based study.
Title: Expression, immune infiltration and clinical significance of SPAG5 in hepatocellular carcinoma: A gene expression-based study.
Investigation of the SPAG5 gene expression and amplification related to the NuMA mRNA levels in breast ductal carcinoma.
Title: Investigation of the SPAG5 gene expression and amplification related to the NuMA mRNA levels in breast ductal carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with sperm associated antigen 5 (SPAG5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH102973 (e-PCR)
- UniSTS:97307

D1S3690 (e-PCR)
- UniSTS:474268

RH79796 (e-PCR)
- UniSTS:89253

G21480 (e-PCR)
- UniSTS:76245

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metaphase plate congression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	IMP Inferred from Mutant Phenotype more info	PubMed
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary rootlet	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: sperm-associated antigen 5

Names: astrin; mitotic spindle associated protein p126; mitotic spindle coiled-coil related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006461.4 → NP_006452.3 sperm-associated antigen 5

See identical proteins and their annotated locations for NP_006452.3

Status: REVIEWED

Source sequence(s)

BC000322, BI459711, BQ773438

Consensus CDS

CCDS32594.1

UniProtKB/Swiss-Prot

O95213, Q96R06, Q9BWE8, Q9NT17, Q9UFE6

UniProtKB/TrEMBL

A8K8N3

Related

ENSP00000323300.5, ENST00000321765.10

Conserved Domains (2) summary

COG1196
Location:594 → 1163

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam04598
Location:742 → 944

Gasdermin; Gasdermin family