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    Kcnk10 potassium channel, subfamily K, member 10 [ Mus musculus (house mouse) ]

    Gene ID: 72258, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kcnk10provided by MGI
    Official Full Name
    potassium channel, subfamily K, member 10provided by MGI
    Primary source
    MGI:MGI:1919508
    See related
    Ensembl:ENSMUSG00000033854 AllianceGenome:MGI:1919508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trek2; 1700024D23Rik; 3010005K24Rik
    Summary
    Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Orthologous to human KCNK10 (potassium two pore domain channel subfamily K member 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 3.9), CNS E18 (RPKM 2.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnk10 in Genome Data Viewer
    Location:
    12 E; 12 49.86 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98395691..98544472, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98429432..98578213, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene galactosylceramidase Neighboring gene STARR-positive B cell enhancer ABC_E8497 Neighboring gene STARR-positive B cell enhancer ABC_E8498 Neighboring gene STARR-positive B cell enhancer ABC_E5347 Neighboring gene STARR-positive B cell enhancer ABC_E11519 Neighboring gene G-protein coupled receptor 65 Neighboring gene STARR-positive B cell enhancer mm9_chr12:99698044-99698344 Neighboring gene predicted gene, 40893 Neighboring gene STARR-seq mESC enhancer starr_32997 Neighboring gene STARR-positive B cell enhancer mm9_chr12:99839121-99839422 Neighboring gene STARR-seq mESC enhancer starr_32998 Neighboring gene predicted gene, 25486 Neighboring gene spermatogenesis associated 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Higher expression of KCNK10 (TREK-2) K(+) channels and their functional upregulation by lipopolysaccharide treatment in mouse peritoneal B1a cells. Choi SW, et al. Pflugers Arch, 2021 Apr. PMID 33586023
    2. RNA interference-mediated knockdown of the mouse gene encoding potassium channel subfamily K member 10 inhibits hormone-induced differentiation of 3T3-L1 preadipocytes. Sato S, et al. Comp Biochem Physiol B Biochem Mol Biol, 2010 Sep. PMID 20462519
    3. Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene. Mirkovic K, et al. Neuroscience, 2011 Oct 27. PMID 21821104, Free PMC Article
    4. Functional expression of TREK-2 in insulin-secreting MIN6 cells. Kang D, et al. Biochem Biophys Res Commun, 2004 Oct 8. PMID 15351740
    5. TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons. Lengyel M, et al. J Biol Chem, 2020 Aug 28. PMID 32641496, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beta-COP Suppresses the Surface Expression of the TREK2.
      Title: β-COP Suppresses the Surface Expression of the TREK2.
    2. Higher expression of KCNK10 (TREK-2) K(+) channels and their functional upregulation by lipopolysaccharide treatment in mouse peritoneal B1a cells.
      Title: Higher expression of KCNK10 (TREK-2) K(+) channels and their functional upregulation by lipopolysaccharide treatment in mouse peritoneal B1a cells.
    3. TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.
      Title: TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.
    4. These findings identify TREK2 as a potential molecular targets in migraine.
      Title: Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.
    5. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins
      Title: Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.
    6. Formation of TREK-1/TREK-2 channels was also demonstrated in native dorsal root ganglion neurons indicating that heterodimerization may provide greater diversity of leak K(+) conductances also in native tissues.
      Title: Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.
    7. The results suggest that positive modulation of the TREK2 channel may have beneficial analgesic effects in these neuropathic conditions.
      Title: Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
    8. Polycystins protect renal epithelial cells against apoptosis in response to mechanical stress, and this function is mediated through the opening of stretch-activated K(2P) channels.
      Title: Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.
    9. Two novel splice isoforms of Trek2 are characterized, both showing prominent expression in the central nervous system and suggesting a potential role for Trek2 amino terminus in channel trafficking and/or stability.
      Title: Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene.
    10. KCNK10 plays an important role in the early stages of preadipocyte differentiation.
      Title: RNA interference-mediated knockdown of the mouse gene encoding potassium channel subfamily K member 10 inhibits hormone-induced differentiation of 3T3-L1 preadipocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 10
    Names
    TREK-2 two-pore-domain K+ channel
    outward rectifying potassium channel TREK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316664.1 → NP_001303593.1  potassium channel subfamily K member 10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AC124516, AC134249, AK031904
      Consensus CDS
      CCDS88386.1
      UniProtKB/TrEMBL
      Q8BZB0
      Related
      ENSMUSP00000105740.3, ENSMUST00000110113.3
      Conserved Domains (1) summary
      pfam07885
      Location:135 → 189
      Ion_trans_2; Ion channel

    2. NM_001316665.1 → NP_001303594.1  potassium channel subfamily K member 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC124516, AC134249, AK019376, AK031904
      UniProtKB/TrEMBL
      Q3LS20, Q8BZB0
      Conserved Domains (1) summary
      pfam07885
      Location:152 → 206
      Ion_trans_2; Ion channel

    3. NM_001316666.1 → NP_001303595.1  potassium channel subfamily K member 10 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the UTRs and coding sequence compared to variant 3. The resulting isoform (4) has shorter and distinct N- and C-termini compared to isoform 3.
      Source sequence(s)
      AC134249, AK019376
      Consensus CDS
      CCDS88385.1
      Related
      ENSMUSP00000152656.2, ENSMUST00000221305.2
      Conserved Domains (1) summary
      pfam07885
      Location:148 → 206
      Ion_trans_2; Ion channel

    4. NM_029911.5 → NP_084187.2  potassium channel subfamily K member 10 isoform 1

      See identical proteins and their annotated locations for NP_084187.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AC134249, AK031904, AK036066
      Consensus CDS
      CCDS36518.1
      UniProtKB/Swiss-Prot
      A0A1Y7VJZ9, F6YU65, Q8BUW1, Q9CX88
      UniProtKB/TrEMBL
      Q8BZB0
      Related
      ENSMUSP00000152473.2, ENSMUST00000221240.2
      Conserved Domains (1) summary
      pfam07885
      Location:145 → 203
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      98395691..98544472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516259.5 → XP_006516322.1  potassium channel subfamily K member 10 isoform X4

      Conserved Domains (1) summary
      pfam07885
      Location:152 → 206
      Ion_trans_2; Ion channel

    2. XM_011244181.3 → XP_011242483.1  potassium channel subfamily K member 10 isoform X1

      See identical proteins and their annotated locations for XP_011242483.1

      UniProtKB/TrEMBL
      Q8BZB0
      Conserved Domains (1) summary
      pfam07885
      Location:135 → 189
      Ion_trans_2; Ion channel

    3. XM_006516257.4 → XP_006516320.1  potassium channel subfamily K member 10 isoform X2

      UniProtKB/TrEMBL
      Q8BZB0
      Conserved Domains (1) summary
      pfam07885
      Location:94 → 152
      Ion_trans_2; Ion channel

    4. XM_036157621.1 → XP_036013514.1  potassium channel subfamily K member 10 isoform X2

      UniProtKB/TrEMBL
      Q8BZB0
      Conserved Domains (1) summary
      pfam07885
      Location:94 → 152
      Ion_trans_2; Ion channel

    5. XM_036157622.1 → XP_036013515.1  potassium channel subfamily K member 10 isoform X3

      Conserved Domains (1) summary
      pfam07885
      Location:148 → 206
      Ion_trans_2; Ion channel
    Nucleotide Protein Strain
    Heading Accession and Version

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