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    Poc5 POC5 centriolar protein [ Mus musculus (house mouse) ]

    Gene ID: 67463, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Poc5provided by MGI
    Official Full Name
    POC5 centriolar proteinprovided by MGI
    Primary source
    MGI:MGI:1914713
    See related
    Ensembl:ENSMUSG00000021671 AllianceGenome:MGI:1914713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200014M14Rik
    Summary
    Predicted to be involved in eye photoreceptor cell development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in centrosome and photoreceptor connecting cilium. Is expressed in central nervous system; ganglia; and sensory organ. Orthologous to human POC5 (POC5 centriolar protein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.2), whole brain E14.5 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Poc5 in Genome Data Viewer
    Location:
    13 D1; 13 50.56 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (96524767..96553719)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (96388259..96417211)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2c Neighboring gene STARR-seq mESC enhancer starr_35337 Neighboring gene predicted gene 29543 Neighboring gene STARR-seq mESC enhancer starr_35340 Neighboring gene STARR-seq mESC enhancer starr_35341 Neighboring gene STARR-seq mESC enhancer starr_35342 Neighboring gene STARR-seq mESC enhancer starr_35344 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:97157941-97158317 Neighboring gene SNF8, ESCRT-II complex subunit, homolog pseudogene Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene STARR-positive B cell enhancer ABC_E1884 Neighboring gene STARR-positive B cell enhancer ABC_E2418 Neighboring gene polymerase (DNA directed), kappa Neighboring gene ceramide transporter 1 Neighboring gene predicted gene, 46436

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in eye photoreceptor cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in photoreceptor connecting cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein POC5
    Names
    POC5 centriolar protein homolog
    protein of centriole 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026173.3 → NP_080449.1  centrosomal protein POC5

      See identical proteins and their annotated locations for NP_080449.1

      Status: VALIDATED

      Source sequence(s)
      AK004769, AK150656
      Consensus CDS
      CCDS26703.1
      UniProtKB/Swiss-Prot
      Q8C299, Q8CI36, Q9CZ74, Q9DBS8
      Related
      ENSMUSP00000096898.5, ENSMUST00000099295.6
      Conserved Domains (2) summary
      TIGR02168
      Location:176 → 377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR03895
      Location:346 → 504
      protease_PatA; cyanobactin maturation protease, PatA/PatG family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      96524767..96553719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517751.4 → XP_006517814.1  centrosomal protein POC5 isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:150 → 351
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl10459
      Location:320 → 478
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

    RNA

    1. XR_001780803.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBS8.1 GenPept UniProtKB/Swiss-Prot:Q9DBS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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