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    Kap-alpha1 karyopherin alpha1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40160, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kap-alpha1provided by FlyBase
    Official Full Name
    karyopherin alpha1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024889
    Locus tag
    Dmel_CG8548
    See related
    AllianceGenome:FB:FBgn0024889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alphaKap1; anon-WO0118547.276; CG8548; Dalpha1; Dmalpha1; Dmel\CG8548; imp alpha1; Imp alpha1; imp-alpha1; Imp-alpha1; impalpha1; Impalpha1; IMPalpha1; Kap alpha1; Kapalpha1S1; Kpna1
    Summary
    Enables nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in adult head and organism. Orthologous to several human genes including KPNA1 (karyopherin subunit alpha 1) and KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Kap-alpha1 in Genome Data Viewer
    Location:
    76C6-76C6; 3-46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19807232..19810398)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19800332..19803498)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain-containing 58 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 305a1 Neighboring gene cycle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal control of expression with light-gated LOV-LexA. Ribeiro IMA, et al. G3 (Bethesda), 2022 Sep 30. PMID 35876796, Free PMC Article
    2. Drosophila Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche. Heaney J, et al. Cells, 2024 Mar 12. PMID 38534338, Free PMC Article
    3. Novel nicotinic action of the sulfoximine insecticide sulfoxaflor. Watson GB, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21296156
    4. Patterns of importin-alpha expression during Drosophila spermatogenesis. Giarrè M, et al. J Struct Biol, 2002 Oct-Dec. PMID 12490175
    5. The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors. Beckmann JF, et al. Elife, 2019 Nov 27. PMID 31774393, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study identified a potential nuclear localization signal at the N-terminal end of Yorkie as well as a critical role for Importin alpha 1 in Yorkie nuclear import.
      Title: Importin α1 Mediates Yorkie Nuclear Import via an N-terminal Non-canonical Nuclear Localization Signal.
    2. This is supported by attenuated interaction of IMPa1 with TIM carrying a mutation previously shown to prevent nuclear entry of TIM and PER.
      Title: Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.
    3. Drosophila alpha1 performs paralog-specific activities that are essential for gametogenesis and regulation of subcellular alpha1 localization may affect cell fate decisions.
      Title: Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis.
    4. each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
      Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NLS-bearing protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    karyopherin alpha1
    Names
    CG8548-PA
    Kap-alpha1-PA
    importin alpha1
    importin-alpha1
    karyopherin alpha 1
    karyopherin-alpha1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19807232..19810398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079443.2 → NP_524167.1  karyopherin alpha1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76521, Q9U1H6
      Related
      FBpp0074650
      Conserved Domains (5) summary
      COG5064
      Location:1 → 543
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:131 → 252
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:3 → 116
      IBB; Importin beta binding domain
      pfam16186
      Location:473 → 517
      Arm_3; Atypical Arm repeat
      sd00043
      Location:133 → 165
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76521 O76521
    Q5U119 Q5U119
    Q8MZI6 Q8MZI6
    Q9U1H6 Q9U1H6

    Gene LinkOut

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