trc tricornered [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: trcprovided by FlyBase
Official Full Name: tricorneredprovided by FlyBase
Primary source: FLYBASE:FBgn0003744
Locus tag: Dmel_CG8637
See related: AllianceGenome:FB:FBgn0003744
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0669/17; CG8637; Dmel\CG8637; dmTRC; l(3)76BDa; l(3)S066917; Ndr; NDR; RE-D; Trc
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including neuron differentiation; peptidyl-serine phosphorylation; and regulation of cell projection organization. Located in several cellular components, including cell body; cell hair; and dendrite. Is expressed in adult head; follicle cell; and organism. Orthologous to several human genes including STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 76D1-76D1; 3-46 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19830864..19834304, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19823964..19827404, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development.
Title: NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development.
Data show that Tricornered Kinase (Trc) regulates the Wiskott-Aldrich syndrome protein (WASP) levels largely, by regulating the transcription of WASP.
Title: Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein.
The regulation of Warts conformation by Mats, Fat/Dachsous signaling, and Dachs appears independent of Warts phosphorylation by Hippo kinase, establishing a precedent for the control of Nuclear Dbf2-related kinases
Title: Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts.
Full length Fry and Trc show only partial co-localization in growing bristles while an amino terminal fragment of Fry shows close to complete co-localization with Trc suggests that the interaction between these proteins is transient and regulated.
Title: The Drosophila Fry protein interacts with Trc and is highly mobile in vivo.
Mutations in trc and wts genes lead to changes in cell shape, cellular levels of F-actin, the timing of differentiation, and the expression of multiple wing hairs and DE-Cadherin.
Title: Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes.
Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
Title: The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway.
biochemical and genetic evidence for the tumour suppressor kinase Hippo (Hpo) as an upstream regulator of Wts and Trc for dendrite maintenance and tiling, respectively
Title: The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.
trc is regulated by phosphorylation and interacts with fry during wing hair development.
Title: The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule sliding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell hair	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: tricornered

Names: CG8637-PA; CG8637-PB; nuclear Dbf2-related protein kinase; trc-PA; trc-PB; tricorner

NP_001262071.1

EC 2.7.11.1

NP_524170.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19830864..19834304 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275142.1 → NP_001262071.1 tricornered, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262071.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24464, Q9NBK5, Q9NGW6, Q9VW46

UniProtKB/TrEMBL

M9PG43

Conserved Domains (2) summary

smart00935
Location:16 → 85

OmpH; Outer membrane protein (OmpH-like)

cd05599
Location:91 → 455

STKc_NDR_like; Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases
NM_079446.4 → NP_524170.2 tricornered, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524170.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NBK5

Related

FBpp0074691

Conserved Domains (2) summary

smart00935
Location:16 → 85

OmpH; Outer membrane protein (OmpH-like)

cd05599
Location:91 → 451

STKc_NDR_like; Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases