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    Spt6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44000, updated on 19-Jun-2024

    Summary

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    Official Symbol
    Spt6provided by FlyBase
    Primary source
    FLYBASE:FBgn0028982
    Locus tag
    Dmel_CG12225
    See related
    AllianceGenome:FB:FBgn0028982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6; l(1)G0063; spt 6; spt6; SPT6
    Summary
    Enables RNA polymerase II complex binding activity and chromatin binding activity. Involved in ovarian follicle cell development; positive regulation of cellular biosynthetic process; and transcription by RNA polymerase II. Located in chromosome and histone locus body. Part of transcription elongation factor complex. Is expressed in adult head; female germline cyst; germline stem cell; and organism. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Spt6 in Genome Data Viewer
    Location:
    5E4-5E4; 1-16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6267797..6274984)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6161830..6169017)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Spliceosomal protein on the X Neighboring gene schlank Neighboring gene Josephin domain containing Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-5E Neighboring gene long non-coding RNA:CR45530

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates. Ramachandran S, et al. Mol Cell, 2017 Dec 21. PMID 29225036, Free PMC Article
    2. Facts about FACT and transcript elongation through chromatin. Belotserkovskaya R, et al. Curr Opin Genet Dev, 2004 Apr. PMID 15196460
    3. A fluorescent quantitative PCR approach to map gene deletions in the Drosophila genome. Chiang PW, et al. Genetics, 1999 Nov. PMID 10545461, Free PMC Article
    4. The trithorax group proteins Kismet and ASH1 promote H3K36 dimethylation to counteract Polycomb group repression in Drosophila. Dorighi KM, et al. Development, 2013 Oct. PMID 24004944, Free PMC Article
    5. Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila. Houseley JM, et al. Hum Mol Genet, 2005 Mar 15. PMID 15703191

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spt6
    Names
    CG12225-PA
    CG12225-PB
    Spt6-PA
    Spt6-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6267797..6274984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143705.3 → NP_651962.2  Spt6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651962.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960J2, Q9U8B5, Q9U8B6, Q9W420
      UniProtKB/TrEMBL
      B6IDH0, N0D8I3
      Related
      FBpp0070861
      Conserved Domains (8) summary
      cd09918
      Location:1336 → 1420
      SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
      cd09928
      Location:1429 → 1524
      SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
      pfam00575
      Location:1220 → 1281
      S1; S1 RNA binding domain
      pfam14633
      Location:1309 → 1523
      SH2_2; SH2 domain
      pfam14641
      Location:308 → 411
      HTH_44; Helix-turn-helix DNA-binding domain of SPT6
      pfam14878
      Location:1057 → 1159
      DLD; Death-like domain of SPT6
      cl21482
      Location:781 → 935
      RuvC_resolvase; Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes ...
      cl22429
      Location:939 → 1042
      HHH_5; Helix-hairpin-helix domain

    2. NM_001298007.1 → NP_001284936.1  Spt6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960J2, Q9U8B5, Q9U8B6, Q9W420
      UniProtKB/TrEMBL
      B6IDH0, N0D8I3
      Conserved Domains (8) summary
      cd09918
      Location:1336 → 1420
      SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
      cd09928
      Location:1429 → 1524
      SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
      pfam00575
      Location:1220 → 1281
      S1; S1 RNA binding domain
      pfam14633
      Location:1309 → 1523
      SH2_2; SH2 domain
      pfam14641
      Location:308 → 411
      HTH_44; Helix-turn-helix DNA-binding domain of SPT6
      pfam14878
      Location:1057 → 1159
      DLD; Death-like domain of SPT6
      cl21482
      Location:781 → 935
      RuvC_resolvase; Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes ...
      cl22429
      Location:939 → 1042
      HHH_5; Helix-hairpin-helix domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    N0D8I3 N0D8I3
    Q9W420.1 Q9W420

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