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    Micu3 mitochondrial calcium uptake family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 78506, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Micu3provided by MGI
    Official Full Name
    mitochondrial calcium uptake family, member 3provided by MGI
    Primary source
    MGI:MGI:1925756
    See related
    Ensembl:ENSMUSG00000039478 AllianceGenome:MGI:1925756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Efha2; 2900075B16Rik
    Summary
    Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion. Is active in mitochondrion. Orthologous to human MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 8.6), frontal lobe adult (RPKM 5.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Micu3 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40760394..40841824)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40307438..40388782)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene Neighboring gene fibroblast growth factor 20 Neighboring gene microRNA 7666 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction. Zhou G, et al. Int Immunopharmacol, 2023 Apr. PMID 36878048
    2. MICU3 Plays an Important Role in Cardiovascular Function. Puente BN, et al. Circ Res, 2020 Dec 4. PMID 33059536, Free PMC Article
    3. Loss of mitochondrial Ca(2+) uptake protein 3 impairs skeletal muscle calcium handling and exercise capacity. Roman B, et al. J Physiol, 2024 Jan. PMID 38018177,
    4. MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy. Roman B, et al. Circ Res, 2024 Jun 21. PMID 38747181,
    5. MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake. Patron M, et al. Cell Death Differ, 2019 Jan. PMID 29725115, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy.
      Title: MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy.
    2. Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction.
      Title: Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction.
    3. MICU3 forms a disulfide bond-mediated dimer with MICU1, but not with MICU2, and it acts as enhancer of MCU-dependent mitochondrial Ca(2+) uptake. Silencing of MICU3 in primary cortical neurons impairs Ca(2+) signals elicited by synaptic activity, thus suggesting a specific role in regulating neuronal function.
      Title: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.
    4. MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake
      Title: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion sensor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect positive regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium uptake protein 3, mitochondrial
    Names
    EF-hand domain family, member A2
    EF-hand domain-containing family member A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030110.2 → NP_084386.1  calcium uptake protein 3, mitochondrial

      See identical proteins and their annotated locations for NP_084386.1

      Status: VALIDATED

      Source sequence(s)
      AC102680, AC160537
      Consensus CDS
      CCDS52545.1
      UniProtKB/Swiss-Prot
      Q9CTY5
      Related
      ENSMUSP00000070241.8, ENSMUST00000068999.14
      Conserved Domains (2) summary
      pfam05763
      Location:349 → 437
      DUF835; Protein of unknown function (DUF835)
      pfam13833
      Location:442 → 495
      EF-hand_8; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      40760394..40841824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509522.4 → XP_006509585.1  calcium uptake protein 3, mitochondrial isoform X1

      Conserved Domains (2) summary
      PTZ00183
      Location:231 → 346
      PTZ00183; centrin; Provisional
      cd16175
      Location:229 → 483
      EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins

    2. XM_017313013.3 → XP_017168502.1  calcium uptake protein 3, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0JLX6
      Conserved Domains (1) summary
      cd16175
      Location:60 → 327
      EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CTY5.2 GenPept UniProtKB/Swiss-Prot:Q9CTY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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