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    Evi5l ecotropic viral integration site 5 like [ Mus musculus (house mouse) ]

    Gene ID: 213027, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Evi5lprovided by MGI
    Official Full Name
    ecotropic viral integration site 5 likeprovided by MGI
    Primary source
    MGI:MGI:2442167
    See related
    Ensembl:ENSMUSG00000011832 AllianceGenome:MGI:2442167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700084G18Rik; 2310039H16Rik; 3110007G05Rik; B130050I23Rik
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in negative regulation of cilium assembly and positive regulation of GTPase activity. Is expressed in cortical plate. Orthologous to human EVI5L (ecotropic viral integration site 5 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 42.8), CNS E18 (RPKM 22.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Evi5l in Genome Data Viewer
    Location:
    8 A1.1; 8 1.95 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4216523..4258089)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4166551..4208089)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CD209f antigen Neighboring gene STARR-seq mESC enhancer starr_20605 Neighboring gene CD209g antigen Neighboring gene STARR-seq mESC enhancer starr_20606 Neighboring gene STARR-seq mESC enhancer starr_20608 Neighboring gene RIKEN cDNA 4932443L11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:4162949-4163058 Neighboring gene STARR-positive B cell enhancer ABC_E355 Neighboring gene STARR-seq mESC enhancer starr_20610 Neighboring gene proline rich 36 Neighboring gene leucine rich repeat containing 8 family, member E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vitro selection of Jun-associated proteins using mRNA display. Horisawa K, et al. Nucleic Acids Res, 2004 Dec 2. PMID 15576676, Free PMC Article
    2. Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l. Anderson AE, et al. Mol Cell Biol, 2017 Mar 1. PMID 27956704, Free PMC Article
    3. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, et al. Neuron, 2021 Jan 20. PMID 33220177, Free PMC Article
    4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
    5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29047

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EVI5-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039578.4 → NP_001034667.4  EVI5-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123029, AK045240
      Consensus CDS
      CCDS40207.2
      UniProtKB/TrEMBL
      A0A6I8MWZ4, H3BJX1
      Related
      ENSMUSP00000159328.2, ENSMUST00000239400.2
      Conserved Domains (1) summary
      smart00164
      Location:112 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_001346730.2 → NP_001333659.2  EVI5-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123029
      Consensus CDS
      CCDS85495.1
      UniProtKB/TrEMBL
      H3BJ67, H3BKQ3
      Related
      ENSMUSP00000135479.3, ENSMUST00000176149.9
      Conserved Domains (2) summary
      smart00164
      Location:112 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:358 → 715
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001368791.1 → NP_001355720.1  EVI5-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123029
      UniProtKB/TrEMBL
      H3BJ67
      Conserved Domains (2) summary
      smart00164
      Location:133 → 341
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:379 → 729
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. NM_001368792.1 → NP_001355721.1  EVI5-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123029
      UniProtKB/TrEMBL
      H3BJ67
      Conserved Domains (2) summary
      smart00164
      Location:133 → 341
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:379 → 736
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001368794.1 → NP_001355723.1  EVI5-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123029
      UniProtKB/TrEMBL
      H3BJ67, H3BL92
      Related
      ENSMUSP00000135700.3, ENSMUST00000176825.3
      Conserved Domains (2) summary
      smart00164
      Location:112 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:358 → 708
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4216523..4258089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153868.1 → XP_036009761.1  EVI5-like protein isoform X1

      UniProtKB/TrEMBL
      H3BJ67
      Conserved Domains (2) summary
      smart00164
      Location:22 → 230
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:268 → 625
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_036153869.1 → XP_036009762.1  EVI5-like protein isoform X2

      UniProtKB/TrEMBL
      H3BJ67
      Conserved Domains (2) summary
      smart00164
      Location:22 → 230
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:268 → 590
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006508749.3 → XP_006508812.1  EVI5-like protein isoform X3

      UniProtKB/TrEMBL
      H3BJX1
      Conserved Domains (1) summary
      smart00164
      Location:133 → 341
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RNA

    1. XR_004934796.1 RNA Sequence

    2. XR_004934795.1 RNA Sequence

    3. XR_004934794.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153536.2: Suppressed sequence

      Description
      NM_153536.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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