U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LMNTD2 lamin tail domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 256329, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LMNTD2provided by HGNC
    Official Full Name
    lamin tail domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:28561
    See related
    Ensembl:ENSG00000185522 AllianceGenome:HGNC:28561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C11orf35
    Summary
    Predicted to be a structural constituent of chromatin. Predicted to act upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in lamin filament. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 5.4), lung (RPKM 3.1) and 22 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LMNTD2 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (554850..560738, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (601835..607742, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (554850..560738, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21531 Neighboring gene leucine rich repeat containing 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:528505-529042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:533792-534649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:534650-535506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:535528-536235 Neighboring gene HRas proto-oncogene, GTPase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:540668-541490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:543860-544362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:544865-545366 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:548147-548965 and GRCh37_chr11:548966-549783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:556675-557511 Neighboring gene LMNTD2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:561773-562348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:565694-566248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:566249-566803 Neighboring gene Ras association domain family member 7 Neighboring gene MIR210 host gene Neighboring gene microRNA 210

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC35138

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lamin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lamin tail domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173573.3 → NP_775844.2  lamin tail domain-containing protein 2

      See identical proteins and their annotated locations for NP_775844.2

      Status: VALIDATED

      Source sequence(s)
      AI539379, AP006284, BC039077, BX384084, BX384085
      Consensus CDS
      CCDS7701.1
      UniProtKB/Swiss-Prot
      Q8IXW0
      Related
      ENSP00000331167.3, ENST00000329451.8
      Conserved Domains (3) summary
      pfam00932
      Location:372 → 464
      LTD; Lamin Tail Domain
      cd16269
      Location:138 → 148
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:109 → 160
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      554850..560738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426713.1 → XP_047282669.1  lamin tail domain-containing protein 2 isoform X3

    2. XM_047426712.1 → XP_047282668.1  lamin tail domain-containing protein 2 isoform X2

    3. XM_011519967.3 → XP_011518269.2  lamin tail domain-containing protein 2 isoform X4

    4. XM_011519965.3 → XP_011518267.2  lamin tail domain-containing protein 2 isoform X1

    5. XM_017017479.3 → XP_016872968.1  lamin tail domain-containing protein 2 isoform X5

    6. XM_047426714.1 → XP_047282670.1  lamin tail domain-containing protein 2 isoform X6

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      84490..90393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328896.1 → XP_054184871.1  lamin tail domain-containing protein 2 isoform X3

    2. XM_054328894.1 → XP_054184869.1  lamin tail domain-containing protein 2 isoform X11

    3. XM_054328893.1 → XP_054184868.1  lamin tail domain-containing protein 2 isoform X10

    4. XM_054328895.1 → XP_054184870.1  lamin tail domain-containing protein 2 isoform X2

    5. XM_054328891.1 → XP_054184866.1  lamin tail domain-containing protein 2 isoform X1

    6. XM_054328890.1 → XP_054184865.1  lamin tail domain-containing protein 2 isoform X8

    7. XM_054328892.1 → XP_054184867.1  lamin tail domain-containing protein 2 isoform X9

    8. XM_054328889.1 → XP_054184864.1  lamin tail domain-containing protein 2 isoform X7

    9. XM_054328897.1 → XP_054184872.1  lamin tail domain-containing protein 2 isoform X12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      601835..607742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368319.1 → XP_054224294.1  lamin tail domain-containing protein 2 isoform X3

    2. XM_054368317.1 → XP_054224292.1  lamin tail domain-containing protein 2 isoform X17

    3. XM_054368316.1 → XP_054224291.1  lamin tail domain-containing protein 2 isoform X16

    4. XM_054368318.1 → XP_054224293.1  lamin tail domain-containing protein 2 isoform X2

    5. XM_054368314.1 → XP_054224289.1  lamin tail domain-containing protein 2 isoform X1

    6. XM_054368313.1 → XP_054224288.1  lamin tail domain-containing protein 2 isoform X14

    7. XM_054368315.1 → XP_054224290.1  lamin tail domain-containing protein 2 isoform X15

    8. XM_054368312.1 → XP_054224287.1  lamin tail domain-containing protein 2 isoform X13

    9. XM_054368320.1 → XP_054224295.1  lamin tail domain-containing protein 2 isoform X18

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IXW0.2 GenPept UniProtKB/Swiss-Prot:Q8IXW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools