Sirpb1a signal-regulatory protein beta 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirpb1aprovided by MGI
Official Full Name: signal-regulatory protein beta 1Aprovided by MGI
Primary source: MGI:MGI:2444824
See related: Ensembl:ENSMUSG00000095788 AllianceGenome:MGI:2444824
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sirpb; Sirpb1; SIRP-beta; 9930027N05Rik
Summary: Acts upstream of or within intracellular signal transduction and positive regulation of phagocytosis. Located in plasma membrane. Orthologous to human SIRPB1 (signal regulatory protein beta 1) and SIRPG (signal regulatory protein gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 1.3), testis adult (RPKM 1.1) and 9 other tissues See more
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Genomic context

Location:: 3; 3 A1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (15436887..15491487, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (15371661..15426522, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that engagement of SIRPbeta promotes phagocytosis in macrophages by inducing the tyrosine phosphorylation of DAP12, Syk, and SLP-76 and the subsequent activation of a MEK-MAPK-myosin light chain kinase cascade.
Title: Positive regulation of phagocytosis by SIRPbeta and its signaling mechanism in macrophages.
Sirp beta genes encode cell surface molecules containing extracellular Ig domains and short intracytoplasmic domains that have a charged amino acid in the transmembrane region which potentially interacts with ITAM-bearing molecules to mediate signaling.
Title: Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal-regulatory protein beta 1

Names: SIRP beta 1 cell surface protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002898.1 → NP_001002898.1 signal-regulatory protein beta 1

See identical proteins and their annotated locations for NP_001002898.1

Status: PROVISIONAL

Source sequence(s)

AB112022

Consensus CDS

CCDS17252.1

UniProtKB/TrEMBL

A0A0A6YYP6, D3YXM3, Q6F5F2

Related

ENSMUSP00000141504.2, ENSMUST00000192700.3

Conserved Domains (4) summary

cd00098
Location:247 → 341

IgC; Immunoglobulin Constant domain

smart00410
Location:42 → 119

IG_like; Immunoglobulin like

pfam07686
Location:45 → 143

V-set; Immunoglobulin V-set domain

cl11960
Location:142 → 252

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

15436887..15491487 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178792.3: Suppressed sequence

Description

NM_178792.3: This RefSeq was temporarily suppressed because the protein is not supported by available homology data.