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Drd2 dopamine receptor D2 [ Mus musculus (house mouse) ]

Gene ID: 13489, updated on 5-Nov-2024

Summary

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Official Symbol: Drd2provided by MGI
Official Full Name: dopamine receptor D2provided by MGI
Primary source: MGI:MGI:94924
See related: Ensembl:ENSMUSG00000032259 AllianceGenome:MGI:94924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D2R; Drd-2
Summary: Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including hyaloid vascular plexus regression; negative regulation of innate immune response; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including G protein-coupled dopamine receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in axon and dendrite. Is active in several cellular components, including GABA-ergic synapse; dopaminergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 3.9), cortex adult (RPKM 2.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

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See Drd2 in Genome Data Viewer

Location:: 9 A5.3; 9 26.72 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (49251703..49319468)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (49340360..49408177)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus.
Title: Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus.
DRD2 activation inhibits choroidal neovascularization in patients with Parkinson's disease and age-related macular degeneration.
Title: DRD2 activation inhibits choroidal neovascularization in patients with Parkinson's disease and age-related macular degeneration.
Regulatory roles of dopamine D2 receptor in milk protein production and apoptosis in mammary epithelial cells.
Title: Regulatory roles of dopamine D2 receptor in milk protein production and apoptosis in mammary epithelial cells.
Dopamine receptor D2 confers colonization resistance via microbial metabolites.
Title: Dopamine receptor D2 confers colonization resistance via microbial metabolites.
Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function.
Title: Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function.
Dopamine D2 receptors in WFS1-neurons regulate food-seeking and avoidance behaviors.
Title: Dopamine D2 receptors in WFS1-neurons regulate food-seeking and avoidance behaviors.
A novel dopamine D2 receptor-NR2B protein complex might contribute to morphine use disorders.
Title: A novel dopamine D2 receptor-NR2B protein complex might contribute to morphine use disorders.
Activation of the Hippocampal DRD2 Alleviates Neuroinflammation, Synaptic Plasticity Damage and Cognitive Impairment After Sleep Deprivation.
Title: Activation of the Hippocampal DRD2 Alleviates Neuroinflammation, Synaptic Plasticity Damage and Cognitive Impairment After Sleep Deprivation.
Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.
Title: Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.
Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice.
Title: Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice.

Submit: New GeneRIF Correction See all GeneRIFs (279)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (9) 1 citation
Targeted (18) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Drd2 (e-PCR), detects polymorphism
- UniSTS:142864

Drd2 (e-PCR), detects polymorphism
- UniSTS:142865

MARC_13871-13872:1007494510:1 (e-PCR)
- UniSTS:267588

Drd2 (e-PCR), detects polymorphism
- UniSTS:531044

X55674 (e-PCR)
- UniSTS:159874

Drd2 (e-PCR), detects polymorphism
- UniSTS:506860

NoName (e-PCR)
- UniSTS:484854

DRD2 (e-PCR), detects polymorphism
- UniSTS:266487

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables dopamine binding	IDA Inferred from Direct Assay more info	PubMed
enables dopamine binding	ISO Inferred from Sequence Orthology more info
enables dopamine neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP Inferred from Mutant Phenotype more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	IEA Inferred from Electronic Annotation more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables heterotrimeric G-protein binding	IEA Inferred from Electronic Annotation more info
enables heterotrimeric G-protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of G protein-coupled dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G protein-coupled dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in acid secretion	IEA Inferred from Electronic Annotation more info
involved_in acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in arachidonate secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in auditory behavior	IEA Inferred from Electronic Annotation more info
involved_in auditory behavior	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching morphogenesis of a nerve	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of dopamine uptake involved in synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in drinking behavior	IEA Inferred from Electronic Annotation more info
involved_in drinking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaloid vascular plexus regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian sleep/wake cycle, sleep	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in orbitofrontal cortex development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peristalsis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dopamine uptake involved in synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell-derived neurotrophic factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glial cell-derived neurotrophic factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of renal sodium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of dopamine uptake involved in synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter uptake	EXP Inferred from Experiment more info	PubMed
involved_in regulation of neurotransmitter uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structural plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse structural plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amphetamine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cocaine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to histamine	IEA Inferred from Electronic Annotation more info
involved_in response to histamine	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to inactivity	IEA Inferred from Electronic Annotation more info
involved_in response to iron ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striatum development	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled receptor complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
is_active_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: D(2) dopamine receptor

Names: dopamine receptor 2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410193.1 → NP_001397122.1 D(2) dopamine receptor isoform 2

Status: VALIDATED

Source sequence(s)

AC167980
NM_010077.3 → NP_034207.2 D(2) dopamine receptor isoform 1

See identical proteins and their annotated locations for NP_034207.2

Status: VALIDATED

Source sequence(s)

AC167980, AW121101, BC105666, BM932444, DN174660, X55674

Consensus CDS

CCDS40615.1

UniProtKB/Swiss-Prot

P13953, P61168, Q0VGH9

Related

ENSMUSP00000075170.7, ENSMUST00000075764.8

Conserved Domains (1) summary

cd15309
Location:35 → 438

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors