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    KSR1 kinase suppressor of ras 1 [ Homo sapiens (human) ]

    Gene ID: 8844, updated on 14-Nov-2024

    Summary

    Official Symbol
    KSR1provided by HGNC
    Official Full Name
    kinase suppressor of ras 1provided by HGNC
    Primary source
    HGNC:HGNC:6465
    See related
    Ensembl:ENSG00000141068 MIM:601132; AllianceGenome:HGNC:6465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KSR; RSU2
    Summary
    Enables 14-3-3 protein binding activity and ATP binding activity. Involved in positive regulation of MAPK cascade. Located in cytosol; endoplasmic reticulum; and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 8.2), endometrium (RPKM 5.8) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KSR1 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (27456448..27626435)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28397924..28567909)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (25783474..25953461)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371705 Neighboring gene TBC1 domain family member 3 pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:25783139-25783640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25787154-25787857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25788561-25789264 Neighboring gene Sharpr-MPRA regulatory region 12448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25798863-25799627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25799628-25800392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25802427-25802940 Neighboring gene Sharpr-MPRA regulatory region 12304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25806167-25806668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11905 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:25830813-25832012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25833398-25833995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25838597-25839125 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25840412-25841256 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25841257-25842099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25846538-25847174 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:25859917-25860102 Neighboring gene MSANTD3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25865210-25866051 Neighboring gene uncharacterized LOC124903960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25867223-25868022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25869832-25870332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25870333-25870833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25894115-25895067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25896821-25897581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25917327-25917828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25917829-25918328 Neighboring gene integral membrane protein 2B pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25957839-25958656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25964969-25965523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25970104-25970797 Neighboring gene galectin 9 Neighboring gene nitric oxide synthase 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP-kinase scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinase suppressor of Ras 1
    NP_001354739.1
    NP_001381512.1
    NP_001381513.1
    NP_001381514.1
    NP_055053.1
    XP_006722217.1
    XP_011523731.1
    XP_011523733.1
    XP_016880768.1
    XP_016880769.1
    XP_047292941.1
    XP_047292942.1
    XP_047292943.1
    XP_047292944.1
    XP_047292945.1
    XP_047292946.1
    XP_047292947.1
    XP_047292948.1
    XP_047292949.1
    XP_047292950.1
    XP_047292951.1
    XP_047292952.1
    XP_054173639.1
    XP_054173640.1
    XP_054173641.1
    XP_054173642.1
    XP_054173643.1
    XP_054173644.1
    XP_054173645.1
    XP_054173646.1
    XP_054173647.1
    XP_054173648.1
    XP_054173649.1
    XP_054173650.1
    XP_054173651.1
    XP_054173652.1
    XP_054173653.1
    XP_054173654.1
    XP_054173655.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367810.1NP_001354739.1  kinase suppressor of Ras 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (3) summary
      cd14152
      Location:590868
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:41168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:346392
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins
    2. NM_001394583.1NP_001381512.1  kinase suppressor of Ras 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      Consensus CDS
      CCDS92281.1
      UniProtKB/TrEMBL
      A0A2R8Y4X0, A0A2R8Y5H9
      Related
      ENSP00000494552.1, ENST00000644974.2
      Conserved Domains (2) summary
      smart00109
      Location:348390
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14152
      Location:590868
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    3. NM_001394584.1NP_001381513.1  kinase suppressor of Ras 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      UniProtKB/TrEMBL
      A8MY87
      Conserved Domains (2) summary
      smart00109
      Location:1254
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14152
      Location:254532
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    4. NM_001394585.1NP_001381514.1  kinase suppressor of Ras 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366
      UniProtKB/TrEMBL
      A8MY87
      Conserved Domains (2) summary
      smart00109
      Location:1254
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14152
      Location:240518
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    5. NM_014238.2NP_055053.1  kinase suppressor of Ras 1 isoform 1

      See identical proteins and their annotated locations for NP_055053.1

      Status: VALIDATED

      Source sequence(s)
      AC015688, AC069366, BC037586, BC042106, BI829205, BX396814, U43586
      Consensus CDS
      CCDS58532.1
      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Related
      ENSP00000381958.3, ENST00000398988.7
      Conserved Domains (3) summary
      cd00029
      Location:211253
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:475753
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:476740
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      27456448..27626435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436989.1XP_047292945.1  kinase suppressor of Ras 1 isoform X8

    2. XM_047436985.1XP_047292941.1  kinase suppressor of Ras 1 isoform X1

    3. XM_011525429.3XP_011523731.1  kinase suppressor of Ras 1 isoform X2

      See identical proteins and their annotated locations for XP_011523731.1

      UniProtKB/Swiss-Prot
      F8WEA9, H7BYU0, Q13476, Q8IVT5
      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (3) summary
      cd14152
      Location:612890
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:41168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:346392
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins
    4. XM_047436986.1XP_047292942.1  kinase suppressor of Ras 1 isoform X3

    5. XM_006722154.4XP_006722217.1  kinase suppressor of Ras 1 isoform X5

      See identical proteins and their annotated locations for XP_006722217.1

      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (4) summary
      cd00029
      Location:348390
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:576854
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:577841
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13543
      Location:41168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    6. XM_047436987.1XP_047292943.1  kinase suppressor of Ras 1 isoform X6

    7. XM_047436988.1XP_047292944.1  kinase suppressor of Ras 1 isoform X7

    8. XM_011525431.3XP_011523733.1  kinase suppressor of Ras 1 isoform X4

      UniProtKB/TrEMBL
      A0A2R8Y4X0
      Conserved Domains (4) summary
      cd00029
      Location:348390
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:612890
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:613877
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13543
      Location:41168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    9. XM_017025280.3XP_016880769.1  kinase suppressor of Ras 1 isoform X14

    10. XM_017025279.2XP_016880768.1  kinase suppressor of Ras 1 isoform X12

    11. XM_047436991.1XP_047292947.1  kinase suppressor of Ras 1 isoform X8

    12. XM_047436990.1XP_047292946.1  kinase suppressor of Ras 1 isoform X8

      Related
      ENSP00000494039.1, ENST00000644418.1
    13. XM_047436993.1XP_047292949.1  kinase suppressor of Ras 1 isoform X9

    14. XM_047436995.1XP_047292951.1  kinase suppressor of Ras 1 isoform X11

    15. XM_047436992.1XP_047292948.1  kinase suppressor of Ras 1 isoform X9

    16. XM_047436994.1XP_047292950.1  kinase suppressor of Ras 1 isoform X10

    17. XM_047436996.1XP_047292952.1  kinase suppressor of Ras 1 isoform X13

      Related
      ENSP00000381952.2, ENST00000398982.6

    RNA

    1. XR_934587.4 RNA Sequence

    2. XR_007065523.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      28397924..28567909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317671.1XP_054173646.1  kinase suppressor of Ras 1 isoform X8

    2. XM_054317664.1XP_054173639.1  kinase suppressor of Ras 1 isoform X1

    3. XM_054317665.1XP_054173640.1  kinase suppressor of Ras 1 isoform X2

      UniProtKB/Swiss-Prot
      F8WEA9, H7BYU0, Q13476, Q8IVT5
    4. XM_054317666.1XP_054173641.1  kinase suppressor of Ras 1 isoform X3

    5. XM_054317668.1XP_054173643.1  kinase suppressor of Ras 1 isoform X5

    6. XM_054317669.1XP_054173644.1  kinase suppressor of Ras 1 isoform X6

    7. XM_054317670.1XP_054173645.1  kinase suppressor of Ras 1 isoform X7

    8. XM_054317667.1XP_054173642.1  kinase suppressor of Ras 1 isoform X4

    9. XM_054317680.1XP_054173655.1  kinase suppressor of Ras 1 isoform X14

    10. XM_054317678.1XP_054173653.1  kinase suppressor of Ras 1 isoform X12

    11. XM_054317673.1XP_054173648.1  kinase suppressor of Ras 1 isoform X8

    12. XM_054317672.1XP_054173647.1  kinase suppressor of Ras 1 isoform X8

    13. XM_054317675.1XP_054173650.1  kinase suppressor of Ras 1 isoform X9

    14. XM_054317677.1XP_054173652.1  kinase suppressor of Ras 1 isoform X11

    15. XM_054317674.1XP_054173649.1  kinase suppressor of Ras 1 isoform X9

    16. XM_054317676.1XP_054173651.1  kinase suppressor of Ras 1 isoform X10

    17. XM_054317679.1XP_054173654.1  kinase suppressor of Ras 1 isoform X13

    RNA

    1. XR_008484960.1 RNA Sequence

    2. XR_008484961.1 RNA Sequence