Mt1 metallothionein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mt1provided by MGI
Official Full Name: metallothionein 1provided by MGI
Primary source: MGI:MGI:97171
See related: Ensembl:ENSMUSG00000031765 AllianceGenome:MGI:97171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MT-I; Mt-1
Summary: Enables copper ion binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including cellular response to chromate; cellular response to zinc ion; and nitric oxide mediated signal transduction. Located in cytosol and lysosome. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; sensory organ; and ventricular layer. Orthologous to several human genes including MT1A (metallothionein 1A); MT1B (metallothionein 1B); and MT1E (metallothionein 1E). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14.5 (RPKM 1065.3), stomach adult (RPKM 765.6) and 21 other tissues See more
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Genomic context

Location:: 8 C5; 8 46.34 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (94905214..94906955)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94178883..94180327)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglial MT1 activation inhibits LPS-induced neuroinflammation via regulation of metabolic reprogramming.
Title: Microglial MT1 activation inhibits LPS-induced neuroinflammation via regulation of metabolic reprogramming.
Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation.
Title: Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation.
Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption.
Title: Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption.
Metallothionein 1 Overexpression Does Not Protect Against Mitochondrial Disease Pathology in Ndufs4 Knockout Mice.
Title: Metallothionein 1 Overexpression Does Not Protect Against Mitochondrial Disease Pathology in Ndufs4 Knockout Mice.
CpG Site-Specific Regulation of Metallothionein-1 Gene Expression.
Title: CpG Site-Specific Regulation of Metallothionein-1 Gene Expression.
Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver.
Title: Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver.
Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.
Title: Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.
These findings implicate Mt1 as a negative regulator of insulin secretion. The downregulation of Mt1 is associated with beta cell compensation in obesity, whereas increased Mt1 accompanies beta cell failure and type 2 diabetes.
Title: Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.
these results suggest that Metallothionein (MT) may play a protective role against Atopic dermatitis ( development, and that antioxidant and nuclear protective mechanisms may be involved.
Title: The role of metallothionein in a dinitrofluorobenzene-induced atopic dermatitis-like murine model.
Cuprizone-induced demyelination is followed by high upregulation of MT-I/II and megalin immunoreactivity in astrocytes and epithelial and endothelial cells located in cerebral and cerebellar white and gray matter, as well as in choroid plexus and in numerous constituents of the neurogenic niches in subgranular zone (SGZ) of DG and in SVZ of lateral ventricles.
Title: Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mt1 (e-PCR), detects polymorphism
- UniSTS:143922

PMC99995P1 (e-PCR)
- UniSTS:273715

Mt1 (e-PCR), detects polymorphism
- UniSTS:265576

PMC134057P1 (e-PCR)
- UniSTS:270722

Mt1 (e-PCR), detects polymorphism
- UniSTS:502682

PMC164851P1 (e-PCR)
- UniSTS:271521

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to chromate	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detoxification of copper ion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular monoatomic cation homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nitric oxide mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metallothionein-1

Names: metallothionein-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.