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    Snx7 sorting nexin 7 [ Mus musculus (house mouse) ]

    Gene ID: 76561, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Snx7provided by MGI
    Official Full Name
    sorting nexin 7provided by MGI
    Primary source
    MGI:MGI:1923811
    See related
    Ensembl:ENSMUSG00000028007 AllianceGenome:MGI:1923811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510028H01Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including endocytic recycling; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in early endosome membrane. Predicted to be active in early endosome and phagophore assembly site. Orthologous to human SNX7 (sorting nexin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 19.9), duodenum adult (RPKM 18.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx7 in Genome Data Viewer
    Location:
    3 G1; 3 51.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (117575146..117662585, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (117781497..117868936, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08804 Neighboring gene phospholipid phosphatase related 4 Neighboring gene phospholipid phosphatase related 5 Neighboring gene STARR-seq mESC enhancer starr_08806 Neighboring gene STARR-seq mESC enhancer starr_08807 Neighboring gene STARR-seq mESC enhancer starr_08808 Neighboring gene STARR-seq mESC enhancer starr_08809 Neighboring gene STARR-seq mESC enhancer starr_08810 Neighboring gene predicted gene, 52614 Neighboring gene predicted gene, 32344 Neighboring gene STARR-seq mESC enhancer starr_08811 Neighboring gene STARR-seq mESC enhancer starr_08812 Neighboring gene STARR-seq mESC enhancer starr_08813 Neighboring gene STARR-seq mESC enhancer starr_08815 Neighboring gene predicted gene, 26871 Neighboring gene microRNA 137

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EFA6A, a guanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth. Fukaya M, et al. J Neurochem, 2014 Apr. PMID 24261326
    2. TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. Ragancokova D, et al. J Clin Invest, 2014 Mar. PMID 24487590, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107328

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190156.1 → NP_001177085.1  sorting nexin-7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC115029, AC115933, AK038971, AK052487
      UniProtKB/TrEMBL
      F6RSR4
      Related
      ENSMUSP00000128007.2, ENSMUST00000169812.8
      Conserved Domains (2) summary
      cd07284
      Location:90 → 205
      PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
      cl12013
      Location:189 → 380
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_029655.3 → NP_083931.2  sorting nexin-7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK038971, AK052487
      Consensus CDS
      CCDS38615.2
      UniProtKB/Swiss-Prot
      Q9CY18
      UniProtKB/TrEMBL
      F8WI30, Q5M8N3
      Related
      ENSMUSP00000029639.6, ENSMUST00000029639.12
      Conserved Domains (2) summary
      cd07284
      Location:90 → 205
      PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
      cd07666
      Location:189 → 431
      BAR_SNX7; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      117575146..117662585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY18.1 GenPept UniProtKB/Swiss-Prot:Q9CY18

    Gene LinkOut

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