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    Hat1 histone aminotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 107435, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hat1provided by MGI
    Official Full Name
    histone aminotransferase 1provided by MGI
    Primary source
    MGI:MGI:96013
    See related
    Ensembl:ENSMUSG00000027018 AllianceGenome:MGI:96013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KAT1; Hat-1; 2410071B14Rik
    Summary
    Predicted to enable histone H4K12 acetyltransferase activity. Predicted to be involved in subtelomeric heterochromatin formation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain; liver; optic nerve; testis; and thymus primordium. Orthologous to human HAT1 (histone acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 51.2), placenta adult (RPKM 46.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hat1 in Genome Data Viewer
    Location:
    2 C2; 2 42.38 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71219604..71271966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71389260..71441622)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04777 Neighboring gene dynein cytoplasmic 1 intermediate chain 2 Neighboring gene solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71198352-71198535 Neighboring gene STARR-seq mESC enhancer starr_04786 Neighboring gene STARR-seq mESC enhancer starr_04790 Neighboring gene VISTA enhancer mm55 Neighboring gene nuclear protein-NHP2-like protein pseudogene Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene STARR-seq mESC enhancer starr_04791 Neighboring gene STARR-seq mESC enhancer starr_04792 Neighboring gene distal-less homeobox 1, antisense Neighboring gene distal-less homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly. Agudelo Garcia PA, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28666361, Free PMC Article
    2. KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy. Qi Y, et al. Pharmacol Res, 2021 Aug. PMID 34098071
    3. Histone acetyltransferase 1 is required for DNA replication fork function and stability. Agudelo Garcia PA, et al. J Biol Chem, 2020 Jun 19. PMID 32366460, Free PMC Article
    4. Genetic variation in the activity of the histidine catabolic enzymes between inbred strains of mice: a structural locus for a cytosol histidine aminotransferase isozyme (Hat-1). Bulfield G. Biochem Genet, 1978 Dec. PMID 751649
    5. HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome. Yang G, et al. Theranostics, 2019. PMID 31695772, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
      Title: Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
    2. KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
      Title: KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
    3. Histone acetyltransferase 1 is required for DNA replication fork function and stability.
      Title: Histone acetyltransferase 1 is required for DNA replication fork function and stability.
    4. The Hat1(-/-) MEFs exhibit mitochondrial defects suggesting a critical role for Hat1 in mitochondrial function. Taken together, these data show that loss of Hat1 induces multiple hallmarks of early-onset aging.
      Title: Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1).
    5. HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome.
      Title: HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome.
    6. Results suggests that Hat1-dependent acetylation of H4 is directly involved in the recruitment of several bromodomain-containing proteins to chromatin.
      Title: Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly.
    7. The acetyltransferase HAT1 moderates the NF-kappaB inflammatory response by regulating the transcription factor PLZF.
      Title: The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.
    8. Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly.
      Title: Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.
    9. Expression levels of Hat1 promoter mRNA are not significantly different in vitrified oocyte promoter compared with fresh oocytes.
      Title: Effect of vitrification on promoter CpG island methylation patterns and expression levels of DNA methyltransferase 1o, histone acetyltransferase 1, and deacetylase 1 in metaphase II mouse oocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K12 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in subtelomeric heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase type B catalytic subunit
    Names
    histidine aminotransferase 1
    histone acetyltransferase 1
    NP_080391.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026115.4 → NP_080391.2  histone acetyltransferase type B catalytic subunit

      See identical proteins and their annotated locations for NP_080391.2

      Status: PROVISIONAL

      Source sequence(s)
      AK041700
      Consensus CDS
      CCDS16114.1
      UniProtKB/Swiss-Prot
      Q8BY71
      UniProtKB/TrEMBL
      A2ATU9
      Related
      ENSMUSP00000028408.3, ENSMUST00000028408.3
      Conserved Domains (3) summary
      pfam10394
      Location:22 → 184
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
      pfam13673
      Location:181 → 285
      Acetyltransf_10; Acetyltransferase (GNAT) domain
      cl05000
      Location:323 → 408
      CHASE3; CHASE3 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      71219604..71271966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BY71.1 GenPept UniProtKB/Swiss-Prot:Q8BY71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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