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    MYBL2 MYB proto-oncogene like 2 [ Homo sapiens (human) ]

    Gene ID: 4605, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MYBL2provided by HGNC
    Official Full Name
    MYB proto-oncogene like 2provided by HGNC
    Primary source
    HGNC:HGNC:7548
    See related
    Ensembl:ENSG00000101057 MIM:601415; AllianceGenome:HGNC:7548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMYB; B-MYB
    Summary
    The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in bone marrow (RPKM 29.8), lymph node (RPKM 25.5) and 11 other tissues See more
    Orthologs
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    Genomic context

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    See MYBL2 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (43667114..43716482)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45400313..45449683)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42295754..42345122)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:42285347-42285942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17905 Neighboring gene ribosomal protein L27a pseudogene Neighboring gene Sharpr-MPRA regulatory region 2194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17906 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42306550-42307240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17908 Neighboring gene MPRA-validated peak4221 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17909 Neighboring gene uncharacterized LOC101927200 Neighboring gene gametocyte specific factor 1 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42374309-42375128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42394850-42395350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42395351-42395851 Neighboring gene RNA, U6 small nuclear 639, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells. Bayley R, et al. Cancer Res, 2018 Oct 15. PMID 30082276
    2. MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells. Papetti M, et al. J Cell Physiol, 2011 Mar. PMID 20857481, Free PMC Article
    3. B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1). Werwein E, et al. Cell Cycle, 2012 Nov 1. PMID 23032261, Free PMC Article
    4. MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy. Heinrichs S, et al. Elife, 2013 Jul 16. PMID 23878725, Free PMC Article
    5. B-Myb enhances proliferation and suppresses differentiation of keratinocytes in three-dimensional cell culture. Maruyama H, et al. Arch Dermatol Res, 2014 May. PMID 24515894

    See all (181) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-cell RNA sequencing reveals that MYBL2 in malignant epithelial cells is involved in the development and progression of ovarian cancer.
      Title: Single-cell RNA sequencing reveals that MYBL2 in malignant epithelial cells is involved in the development and progression of ovarian cancer.
    2. Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression.
      Title: Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression.
    3. MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer.
      Title: MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer.
    4. CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression.
      Title: CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression.
    5. B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2.
      Title: B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2.
    6. Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation.
      Title: Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation.
    7. Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
      Title: Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
    8. Up-regulation of ABCG2 by MYBL2 deletion drives Chlorin e6-mediated photodynamic therapy resistance in colorectal cancer.
      Title: Up-regulation of ABCG2 by MYBL2 deletion drives Chlorin e6-mediated photodynamic therapy resistance in colorectal cancer.
    9. Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
      Title: Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
    10. Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer.
      Title: Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (94)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC15600

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Myb complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myb-related protein B
    Names
    myb-like protein 2
    v-myb avian myeloblastosis viral oncogene homolog-like 2
    v-myb myeloblastosis viral oncogene homolog-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278610.2 → NP_001265539.1  myb-related protein B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK303249, AL121886, BC007585, DC395847
      Consensus CDS
      CCDS63276.1
      UniProtKB/Swiss-Prot
      P10244
      Related
      ENSP00000380072.4, ENST00000396863.8
      Conserved Domains (4) summary
      smart00717
      Location:59 → 107
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:59 → 105
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:427 → 570
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:39 → 70
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    2. NM_002466.4 → NP_002457.1  myb-related protein B isoform 1

      See identical proteins and their annotated locations for NP_002457.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL121886, BC007585
      Consensus CDS
      CCDS13322.1
      UniProtKB/Swiss-Prot
      B2RBS5, B7Z8D9, F8W6N6, P10244, Q53F07
      Related
      ENSP00000217026.4, ENST00000217026.5
      Conserved Domains (4) summary
      smart00717
      Location:83 → 131
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:83 → 129
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:451 → 594
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:34 → 94
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      43667114..43716482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      45400313..45449683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10244.1 GenPept UniProtKB/Swiss-Prot:P10244

    Gene LinkOut

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