Sgk1 serum/glucocorticoid regulated kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgk1provided by MGI
Official Full Name: serum/glucocorticoid regulated kinase 1provided by MGI
Primary source: MGI:MGI:1340062
See related: Ensembl:ENSMUSG00000019970 AllianceGenome:MGI:1340062
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sgk
Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]
Expression: Ubiquitous expression in colon adult (RPKM 16.7), large intestine adult (RPKM 16.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 9.83 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (21758083..21875802)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (21882184..21999903)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of serum/glucocorticoid-regulated kinase 1 in brain function following cerebral ischemia.
Title: The role of serum/glucocorticoid-regulated kinase 1 in brain function following cerebral ischemia.
Integrating analysis of mRNA expression profiles indicates Sgk1 as a key mediator in muscle-brain crosstalk during resistance exercise.
Title: Integrating analysis of mRNA expression profiles indicates Sgk1 as a key mediator in muscle-brain crosstalk during resistance exercise.
Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening.
Title: Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening.
SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na.
Title: SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na().
SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
Title: SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
SGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFkappaB pathway.
Title: SGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFκB pathway.
Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.
Title: Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.
Association between SGK1 and alpha-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.
Title: Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.
Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.
Title: Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.
Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.
Title: Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.

Submit: New GeneRIF Correction See all GeneRIFs (156)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fj62e01.x1 (e-PCR)
- UniSTS:199692

RH138140 (e-PCR)
- UniSTS:220227

MHAa70f9.seq (e-PCR)
- UniSTS:125291

29.MMHAP68FLB5.seq (e-PCR)
- UniSTS:123870

UniSTS:498405 (e-PCR)
- UniSTS:498405

Sgk (e-PCR), detects polymorphism
- UniSTS:498405

MGI:3693340 (e-PCR)
- UniSTS:498406

UniSTS:498406 (e-PCR)
- UniSTS:498406

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables tau protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to aldosterone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase Sgk1

Names: serum and glucocorticoid-dependent protein kinase

NP_001155317.2

EC 2.7.11.1

NP_001155319.1

EC 2.7.11.1

NP_001155320.1

EC 2.7.11.1

NP_001155321.1

EC 2.7.11.1

NP_001155322.1

EC 2.7.11.1

NP_035491.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161845.2 → NP_001155317.2 serine/threonine-protein kinase Sgk1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

BC070401, BY493368

Consensus CDS

CCDS48515.1

UniProtKB/Swiss-Prot

Q9WVC6

Related

ENSMUSP00000114074.2, ENSMUST00000120509.8

Conserved Domains (2) summary

smart00220
Location:191 → 448

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05602
Location:183 → 521

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
NM_001161847.2 → NP_001155319.1 serine/threonine-protein kinase Sgk1 isoform b

See identical proteins and their annotated locations for NP_001155319.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AC153555, AK159131, BY493368, CN709375

Consensus CDS

CCDS48518.1

UniProtKB/TrEMBL

E9Q8C1

Related

ENSMUSP00000128873.2, ENSMUST00000164659.8

Conserved Domains (2) summary

smart00220
Location:71 → 328

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05602
Location:63 → 401

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
NM_001161848.2 → NP_001155320.1 serine/threonine-protein kinase Sgk1 isoform b

See identical proteins and their annotated locations for NP_001155320.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AK159131, BY493368, BY736002

Consensus CDS

CCDS48518.1

UniProtKB/TrEMBL

E9Q8C1

Conserved Domains (2) summary

smart00220
Location:71 → 328

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05602
Location:63 → 401

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
NM_001161849.2 → NP_001155321.1 serine/threonine-protein kinase Sgk1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AK159131, BY493368, BY786122

Consensus CDS

CCDS48516.1

UniProtKB/TrEMBL

E9Q1B0

Related

ENSMUSP00000097614.4, ENSMUST00000100036.10

Conserved Domains (1) summary

cd05602
Location:76 → 414

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
NM_001161850.2 → NP_001155322.1 serine/threonine-protein kinase Sgk1 isoform d

See identical proteins and their annotated locations for NP_001155322.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AK132234, BY493368, CK626189

Consensus CDS

CCDS48517.1

UniProtKB/Swiss-Prot

Q9WVC6

Related

ENSMUSP00000090343.5, ENSMUST00000092673.11

Conserved Domains (1) summary

cd05602
Location:104 → 442

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
NM_011361.3 → NP_035491.1 serine/threonine-protein kinase Sgk1 isoform e

See identical proteins and their annotated locations for NP_035491.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC153555, AK159131, BY493368

Consensus CDS

CCDS23726.1

UniProtKB/Swiss-Prot

Q3TJN4, Q3UKD0, Q3UKF2, Q3V1V1, Q6NS85, Q9WVC6

Related

ENSMUSP00000020145.6, ENSMUST00000020145.12

Conserved Domains (1) summary

cd05602
Location:90 → 428

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1