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    AFDN afadin, adherens junction formation factor [ Homo sapiens (human) ]

    Gene ID: 4301, updated on 6-Jun-2024

    Summary

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    Official Symbol
    AFDNprovided by HGNC
    Official Full Name
    afadin, adherens junction formation factorprovided by HGNC
    Primary source
    HGNC:HGNC:7137
    See related
    Ensembl:ENSG00000130396 MIM:159559; AllianceGenome:HGNC:7137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AF6; MLLT4; MLL-AF6; l-afadin
    Summary
    This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
    Expression
    Ubiquitous expression in esophagus (RPKM 18.5), lung (RPKM 15.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AFDN in Genome Data Viewer
    Location:
    6q27
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (167826564..167972023)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (169164770..169309528)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (168227244..168372703)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase long chain base subunit 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168167604-168168104 Neighboring gene long intergenic non-protein coding RNA 1558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168199638-168200171 Neighboring gene uncharacterized LOC441179 Neighboring gene Sharpr-MPRA regulatory region 935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17793 Neighboring gene AFDN divergent transcript Neighboring gene Sharpr-MPRA regulatory region 4710 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:168264804-168266003 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168294093-168294968 Neighboring gene uncharacterized LOC107986673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168375775-168376684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168378524-168379100 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:168379101-168379677 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:168380255-168380830 Neighboring gene MPRA-validated peak6321 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168390864-168391364 Neighboring gene uncharacterized LOC100128124 Neighboring gene KIF25 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Clinical characteristics and prognosis of MLL-AF6 positive patients with acute myeloid leukemia]. Zhang MX, et al. Beijing Da Xue Xue Bao Yi Xue Ban, 2021 Oct 18. PMID 34650294, Free PMC Article
    2. Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles. Huxham J, et al. Bioessays, 2021 Jan. PMID 33165933
    3. Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer. Yamamoto T, et al. BMC Cancer, 2015 Apr 12. PMID 25879875, Free PMC Article
    4. Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding. Niu X, et al. Biochemistry, 2007 Dec 25. PMID 18052198
    5. Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1. Keyser J, et al. FEBS Lett, 2007 Nov 27. PMID 17967423

    See all (149) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate.
      Title: Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate.
    2. [Clinical characteristics and prognosis of MLL-AF6 positive patients with acute myeloid leukemia].
      Title: [Clinical characteristics and prognosis of MLL-AF6 positive patients with acute myeloid leukemia].
    3. Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
      Title: Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
    4. Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles.
      Title: Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles.
    5. Afadin binding with interaction partners in adipocytes, among which HDAC6 preferentially interacts with phosphorylated Afadin and acts as a key intermediate to suppress insulin receptor protein levels.
      Title: Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.
    6. The authors report here that the homophilic receptor PTPRK is stabilized at cell-cell contacts in epithelial cells. PTPRK directly and selectively dephosphorylates at least five substrates, including Afadin, PARD3 and delta-catenin family members, which are all important cell-cell adhesion regulators.
      Title: The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion.
    7. high levels of both Claudin-2 and Afadin in primary tumors were associated with poor disease-specific survival, relapse-free survival, lung-specific relapse, and liver-specific relapse
      Title: Afadin cooperates with Claudin-2 to promote breast cancer metastasis.
    8. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells.
      Title: CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231.
    9. AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors.
      Title: Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
    10. miR-188-3p is a novel independent prognostic factor in colorectal cancer patients, which can be partly explained by its effect on MLLT4 expression and migration of cancer cells.
      Title: Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 (MLLT4, Afadin) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat The expression of MLLT4 gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34371

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell adhesion mediated by cadherin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell-cell adhesion mediated by cadherin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of pore complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    afadin
    Names
    ALL1-fused gene from chromosome 6 protein
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
    protein AF-6

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029689.2 RefSeqGene

      Range
      4921..150033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040000.3 → NP_001035089.1  afadin isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has several differences compared to variant 4. The resulting isoform (2) is longer at the N-terminus but has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AB209420, AI271860, AK055689, AL009178, BE503462, D60168
      Consensus CDS
      CCDS47517.1
      UniProtKB/TrEMBL
      Q5TIG5
      Related
      ENSP00000375956.3, ENST00000392108.7
      Conserved Domains (5) summary
      cd01781
      Location:247 → 346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417 → 499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611 → 932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:1008 → 1090
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. NM_001207008.2 → NP_001193937.1  afadin isoform 1

      See identical proteins and their annotated locations for NP_001193937.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has multiple differences compared to variant 4. The resulting isoform (1, also known as AF6i3) contains a C-terminal F-actin-binding site and has been shown to be involved in the regulation of epithelial wound closure and intercellular adhesion (PMID:16882694).
      Source sequence(s)
      AB209420, AL009178, AL049698, AL161973, BE645141, DA200453, DB079271
      Consensus CDS
      CCDS75553.1
      UniProtKB/TrEMBL
      G1UI22
      Related
      ENSP00000375960.2, ENST00000392112.5
      Conserved Domains (5) summary
      cd01781
      Location:246 → 345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:383 → 483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:991 → 1073
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:595 → 916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

    3. NM_001291964.2 → NP_001278893.1  afadin isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AB621809, AL009178, AL049698, AL161973
      Consensus CDS
      CCDS78199.1
      UniProtKB/TrEMBL
      A8MQ02, G1UI22
      Related
      ENSP00000355771.3, ENST00000366806.6
      Conserved Domains (5) summary
      cd01781
      Location:206 → 305
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:376 → 458
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:570 → 891
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:967 → 1049
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl00155
      Location:1 → 90
      UBQ; Ubiquitin-like proteins

    4. NM_001366319.2 → NP_001353248.1  afadin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL009178, AL049698, KT258903
      UniProtKB/TrEMBL
      A0A1P7ZIN0, G1UI22
      Conserved Domains (6) summary
      cd01781
      Location:247 → 346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417 → 499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611 → 932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:1008 → 1090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:1517 → 1678
      DUF4670; Domain of unknown function (DUF4670)

    5. NM_001366320.2 → NP_001353249.1  afadin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL009178, AL049698, AL731868
      Consensus CDS
      CCDS94034.1
      UniProtKB/Swiss-Prot
      O75087, O75088, O75089, P55196, Q59FP0, Q5TIG6, Q5TIG7, Q9NSN7, Q9NU92
      UniProtKB/TrEMBL
      G1UI22
      Related
      ENSP00000404595.2, ENST00000447894.6
      Conserved Domains (6) summary
      cd01781
      Location:247 → 346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417 → 499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611 → 932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:1008 → 1090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:1517 → 1680
      DUF4670; Domain of unknown function (DUF4670)

    6. NM_001366321.2 → NP_001353250.1  afadin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL009178, AL049698, AL731868
      UniProtKB/TrEMBL
      G1UI22
      Conserved Domains (6) summary
      cd01781
      Location:248 → 347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:385 → 485
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:597 → 925
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:1001 → 1083
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl25548
      Location:1510 → 1673
      DUF4670; Domain of unknown function (DUF4670)

    7. NM_001386888.1 → NP_001373817.1  afadin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL009178, AL049698, AL731868
      Consensus CDS
      CCDS94033.1
      UniProtKB/TrEMBL
      A0A804HJ20, G1UI22
      Related
      ENSP00000507324.1, ENST00000683244.1
      Conserved Domains (6) summary
      cd00060
      Location:417 → 499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611 → 939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:247 → 347
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20 → 131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:1015 → 1097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15709
      Location:1469 → 1687
      DUF4670; Domain of unknown function (DUF4670)

    8. NM_001410951.1 → NP_001397880.1  afadin isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL009178, AL049698, AL731868
      Consensus CDS
      CCDS94035.1
      UniProtKB/TrEMBL
      G1UI22, J3KN01
      Related
      ENSP00000252692.6, ENST00000351017.9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      167826564..167972023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418788.1 → XP_047274744.1  afadin isoform X1

      UniProtKB/TrEMBL
      H0Y8U8

    2. XM_047418789.1 → XP_047274745.1  afadin isoform X2

      UniProtKB/TrEMBL
      H0Y8U8

    3. XM_017010878.2 → XP_016866367.1  afadin isoform X27

      UniProtKB/TrEMBL
      G1UI22

    4. XM_006715491.3 → XP_006715554.1  afadin isoform X45

      UniProtKB/TrEMBL
      G1UI22
      Conserved Domains (5) summary
      cd01781
      Location:248 → 347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418 → 500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612 → 940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:1016 → 1098
      PDZ; PDZ domain (Also known as DHR or GLGF)

    5. XM_047418790.1 → XP_047274746.1  afadin isoform X3

      UniProtKB/TrEMBL
      H0Y8U8

    6. XM_047418791.1 → XP_047274747.1  afadin isoform X4

      UniProtKB/TrEMBL
      H0Y8U8

    7. XM_047418814.1 → XP_047274770.1  afadin isoform X28

      UniProtKB/TrEMBL
      G1UI22

    8. XM_047418792.1 → XP_047274748.1  afadin isoform X5

      UniProtKB/TrEMBL
      H0Y8U8

    9. XM_047418793.1 → XP_047274749.1  afadin isoform X6

      UniProtKB/TrEMBL
      H0Y8U8

    10. XM_017010882.2 → XP_016866371.1  afadin isoform X29

      UniProtKB/TrEMBL
      G1UI22

    11. XM_047418794.1 → XP_047274750.1  afadin isoform X7

      UniProtKB/TrEMBL
      H0Y8U8

    12. XM_005266997.3 → XP_005267054.1  afadin isoform X31

      UniProtKB/TrEMBL
      G1UI22
      Conserved Domains (5) summary
      cd01781
      Location:248 → 347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418 → 500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612 → 933
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:1009 → 1091
      PDZ; PDZ domain (Also known as DHR or GLGF)

    13. XM_047418796.1 → XP_047274752.1  afadin isoform X9

      UniProtKB/TrEMBL
      H0Y8U8

    14. XM_047418798.1 → XP_047274754.1  afadin isoform X11

      UniProtKB/TrEMBL
      H0Y8U8

    15. XM_047418800.1 → XP_047274756.1  afadin isoform X13

      UniProtKB/TrEMBL
      H0Y8U8

    16. XM_047418818.1 → XP_047274774.1  afadin isoform X34

      UniProtKB/TrEMBL
      G1UI22

    17. XM_047418801.1 → XP_047274757.1  afadin isoform X14

      UniProtKB/TrEMBL
      H0Y8U8

    18. XM_047418804.1 → XP_047274760.1  afadin isoform X17

      UniProtKB/TrEMBL
      H0Y8U8

    19. XM_047418821.1 → XP_047274777.1  afadin isoform X37

      UniProtKB/TrEMBL
      G1UI22

    20. XM_047418805.1 → XP_047274761.1  afadin isoform X18

      UniProtKB/TrEMBL
      H0Y8U8

    21. XM_047418811.1 → XP_047274767.1  afadin isoform X24

      UniProtKB/TrEMBL
      H0Y8U8

    22. XM_047418824.1 → XP_047274780.1  afadin isoform X41

      UniProtKB/TrEMBL
      G1UI22

    23. XM_047418815.1 → XP_047274771.1  afadin isoform X30

      UniProtKB/TrEMBL
      G1UI22

    24. XM_047418797.1 → XP_047274753.1  afadin isoform X10

      UniProtKB/TrEMBL
      H0Y8U8
      Related
      ENSP00000422166.3, ENST00000515794.3

    25. XM_047418816.1 → XP_047274772.1  afadin isoform X32

      UniProtKB/TrEMBL
      G1UI22

    26. XM_047418820.1 → XP_047274776.1  afadin isoform X36

      UniProtKB/TrEMBL
      G1UI22

    27. XM_047418802.1 → XP_047274758.1  afadin isoform X15

      UniProtKB/TrEMBL
      H0Y8U8

    28. XM_047418808.1 → XP_047274764.1  afadin isoform X21

      UniProtKB/TrEMBL
      H0Y8U8

    29. XM_047418823.1 → XP_047274779.1  afadin isoform X39

      UniProtKB/TrEMBL
      G1UI22

    30. XM_047418810.1 → XP_047274766.1  afadin isoform X23

      UniProtKB/TrEMBL
      H0Y8U8

    31. XM_047418813.1 → XP_047274769.1  afadin isoform X26

      UniProtKB/TrEMBL
      H0Y8U8

    32. XM_047418826.1 → XP_047274782.1  afadin isoform X43

      UniProtKB/TrEMBL
      G1UI22

    33. XM_047418795.1 → XP_047274751.1  afadin isoform X8

      UniProtKB/TrEMBL
      H0Y8U8

    34. XM_047418819.1 → XP_047274775.1  afadin isoform X35

      UniProtKB/TrEMBL
      G1UI22

    35. XM_047418803.1 → XP_047274759.1  afadin isoform X16

      UniProtKB/TrEMBL
      H0Y8U8

    36. XM_047418807.1 → XP_047274763.1  afadin isoform X20

      UniProtKB/TrEMBL
      H0Y8U8

    37. XM_047418822.1 → XP_047274778.1  afadin isoform X38

      UniProtKB/TrEMBL
      G1UI22

    38. XM_047418809.1 → XP_047274765.1  afadin isoform X22

      UniProtKB/TrEMBL
      H0Y8U8

    39. XM_047418812.1 → XP_047274768.1  afadin isoform X25

      UniProtKB/TrEMBL
      H0Y8U8

    40. XM_047418825.1 → XP_047274781.1  afadin isoform X42

      UniProtKB/TrEMBL
      G1UI22

    41. XM_047418799.1 → XP_047274755.1  afadin isoform X12

      UniProtKB/TrEMBL
      H0Y8U8

    42. XM_047418817.1 → XP_047274773.1  afadin isoform X33

      UniProtKB/TrEMBL
      G1UI22

    43. XM_047418806.1 → XP_047274762.1  afadin isoform X19

      UniProtKB/TrEMBL
      H0Y8U8

    44. XM_017010885.2 → XP_016866374.1  afadin isoform X40

      UniProtKB/TrEMBL
      G1UI22
      Conserved Domains (5) summary
      cd01781
      Location:246 → 345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20 → 131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:383 → 483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595 → 916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:992 → 1074
      PDZ; PDZ domain (Also known as DHR or GLGF)

    45. XM_047418827.1 → XP_047274783.1  afadin isoform X44

      UniProtKB/TrEMBL
      G1UI22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      169164770..169309528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355465.1 → XP_054211440.1  afadin isoform X1

      UniProtKB/TrEMBL
      H0Y8U8

    2. XM_054355466.1 → XP_054211441.1  afadin isoform X2

      UniProtKB/TrEMBL
      H0Y8U8

    3. XM_054355491.1 → XP_054211466.1  afadin isoform X27

      UniProtKB/TrEMBL
      G1UI22

    4. XM_054355509.1 → XP_054211484.1  afadin isoform X45

      UniProtKB/TrEMBL
      G1UI22

    5. XM_054355467.1 → XP_054211442.1  afadin isoform X3

      UniProtKB/TrEMBL
      H0Y8U8

    6. XM_054355468.1 → XP_054211443.1  afadin isoform X4

      UniProtKB/TrEMBL
      H0Y8U8

    7. XM_054355492.1 → XP_054211467.1  afadin isoform X28

      UniProtKB/TrEMBL
      G1UI22

    8. XM_054355469.1 → XP_054211444.1  afadin isoform X5

      UniProtKB/TrEMBL
      H0Y8U8

    9. XM_054355470.1 → XP_054211445.1  afadin isoform X6

      UniProtKB/TrEMBL
      H0Y8U8

    10. XM_054355493.1 → XP_054211468.1  afadin isoform X29

      UniProtKB/TrEMBL
      G1UI22

    11. XM_054355471.1 → XP_054211446.1  afadin isoform X7

      UniProtKB/TrEMBL
      H0Y8U8

    12. XM_054355495.1 → XP_054211470.1  afadin isoform X31

      UniProtKB/TrEMBL
      G1UI22

    13. XM_054355473.1 → XP_054211448.1  afadin isoform X9

      UniProtKB/TrEMBL
      H0Y8U8

    14. XM_054355475.1 → XP_054211450.1  afadin isoform X11

      UniProtKB/TrEMBL
      H0Y8U8

    15. XM_054355477.1 → XP_054211452.1  afadin isoform X13

      UniProtKB/TrEMBL
      H0Y8U8

    16. XM_054355498.1 → XP_054211473.1  afadin isoform X34

      UniProtKB/TrEMBL
      G1UI22

    17. XM_054355478.1 → XP_054211453.1  afadin isoform X14

      UniProtKB/TrEMBL
      H0Y8U8

    18. XM_054355481.1 → XP_054211456.1  afadin isoform X17

      UniProtKB/TrEMBL
      H0Y8U8

    19. XM_054355501.1 → XP_054211476.1  afadin isoform X37

      UniProtKB/TrEMBL
      G1UI22

    20. XM_054355482.1 → XP_054211457.1  afadin isoform X18

      UniProtKB/TrEMBL
      H0Y8U8

    21. XM_054355488.1 → XP_054211463.1  afadin isoform X24

      UniProtKB/TrEMBL
      H0Y8U8

    22. XM_054355505.1 → XP_054211480.1  afadin isoform X41

      UniProtKB/TrEMBL
      G1UI22

    23. XM_054355494.1 → XP_054211469.1  afadin isoform X30

      UniProtKB/TrEMBL
      G1UI22

    24. XM_054355474.1 → XP_054211449.1  afadin isoform X10

      UniProtKB/TrEMBL
      H0Y8U8

    25. XM_054355496.1 → XP_054211471.1  afadin isoform X32

      UniProtKB/TrEMBL
      G1UI22

    26. XM_054355500.1 → XP_054211475.1  afadin isoform X36

      UniProtKB/TrEMBL
      G1UI22

    27. XM_054355479.1 → XP_054211454.1  afadin isoform X15

      UniProtKB/TrEMBL
      H0Y8U8

    28. XM_054355485.1 → XP_054211460.1  afadin isoform X21

      UniProtKB/TrEMBL
      H0Y8U8

    29. XM_054355503.1 → XP_054211478.1  afadin isoform X39

      UniProtKB/TrEMBL
      G1UI22

    30. XM_054355487.1 → XP_054211462.1  afadin isoform X23

      UniProtKB/TrEMBL
      H0Y8U8

    31. XM_054355490.1 → XP_054211465.1  afadin isoform X26

      UniProtKB/TrEMBL
      H0Y8U8

    32. XM_054355507.1 → XP_054211482.1  afadin isoform X43

      UniProtKB/TrEMBL
      G1UI22

    33. XM_054355472.1 → XP_054211447.1  afadin isoform X8

      UniProtKB/TrEMBL
      H0Y8U8

    34. XM_054355499.1 → XP_054211474.1  afadin isoform X35

      UniProtKB/TrEMBL
      G1UI22

    35. XM_054355480.1 → XP_054211455.1  afadin isoform X16

      UniProtKB/TrEMBL
      H0Y8U8

    36. XM_054355484.1 → XP_054211459.1  afadin isoform X20

      UniProtKB/TrEMBL
      H0Y8U8

    37. XM_054355502.1 → XP_054211477.1  afadin isoform X38

      UniProtKB/TrEMBL
      G1UI22

    38. XM_054355486.1 → XP_054211461.1  afadin isoform X22

      UniProtKB/TrEMBL
      H0Y8U8

    39. XM_054355489.1 → XP_054211464.1  afadin isoform X25

      UniProtKB/TrEMBL
      H0Y8U8

    40. XM_054355506.1 → XP_054211481.1  afadin isoform X42

      UniProtKB/TrEMBL
      G1UI22

    41. XM_054355476.1 → XP_054211451.1  afadin isoform X12

      UniProtKB/TrEMBL
      H0Y8U8

    42. XM_054355497.1 → XP_054211472.1  afadin isoform X33

      UniProtKB/TrEMBL
      G1UI22

    43. XM_054355483.1 → XP_054211458.1  afadin isoform X19

      UniProtKB/TrEMBL
      H0Y8U8

    44. XM_054355504.1 → XP_054211479.1  afadin isoform X40

      UniProtKB/TrEMBL
      G1UI22

    45. XM_054355508.1 → XP_054211483.1  afadin isoform X44

      UniProtKB/TrEMBL
      G1UI22

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040001.1: Suppressed sequence

      Description
      NM_001040001.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NM_005936.2: Suppressed sequence

      Description
      NM_005936.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55196.3 GenPept UniProtKB/Swiss-Prot:P55196

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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