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    Gal3st1 galactose-3-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 53897, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gal3st1provided by MGI
    Official Full Name
    galactose-3-O-sulfotransferase 1provided by MGI
    Primary source
    MGI:MGI:1858277
    See related
    Ensembl:ENSMUSG00000049721 AllianceGenome:MGI:1858277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cst; Gcst
    Summary
    Enables galactosylceramide sulfotransferase activity. Involved in galactosylceramide metabolic process. Acts upstream of or within galactosylceramide biosynthetic process; myelination; and spermatogenesis. Predicted to be located in membrane. Is expressed in brain; future spinal cord; heart ventricle; and spinal cord cervical region. Orthologous to human GAL3ST1 (galactose-3-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 105.3), duodenum adult (RPKM 57.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gal3st1 in Genome Data Viewer
    Location:
    11 A1; 11 2.81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3933636..3949328)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3983636..3999328)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28367 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene predicted gene, 46265 Neighboring gene predicted gene 11954 Neighboring gene STARR-seq mESC enhancer starr_28368 Neighboring gene SEC14-like lipid binding 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adult-onset depletion of sulfatide leads to axonal degeneration with relative myelin sparing. Dustin E, et al. Glia, 2023 Sep. PMID 37283058, Free PMC Article
    2. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. Ishibashi T, et al. J Neurosci, 2002 Aug 1. PMID 12151530, Free PMC Article
    3. Paranodal axoglial junction is required for the maintenance of the Nav1.6-type sodium channel in the node of Ranvier in the optic nerves but not in peripheral nerve fibers in the sulfatide-deficient mice. Suzuki A, et al. Glia, 2004 May. PMID 15048850
    4. Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis. Zhang Y, et al. Glycobiology, 2005 Jun. PMID 15659616
    5. Sulfatide is essential for the maintenance of CNS myelin and axon structure. Marcus J, et al. Glia, 2006 Mar. PMID 16288467

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lipidomics analysis demonstrated anticipated sulfatide mass deficiency in CST defect mouse brain and revealed novel brain lipidome homeostasis in these mice.
      Title: Alterations in mouse brain lipidome after disruption of CST gene: a lipidomics study.
    2. Data indicate that mice with cerebroside sulfotransferases (Cst) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst deficiency had lower ammonium excretion.
      Title: Sulfatides are required for renal adaptation to chronic metabolic acidosis.
    3. Protein-overload mice exhibited marked kidney injuries, enhancement of hepatic oxidative stress, decreased levels of serum and hepatic sulfatides, and decreased expression of hepatic cerebroside sulfotransferase.
      Title: Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
    4. CST-deficient optic nerves were used to examine migration and proliferation of oligodendrocyte precursor cells.
      Title: Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice.
    5. These findings define transcriptional regulation of CST (Gal3st1) expression as a critical role for BORIS in spermatogenesis.
      Title: Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS.
    6. The number of OLs in the CST-null mice is also increased in the spinal cord and that this elevated OL population is maintained through, at least, 7 months of age.
      Title: Adult CST-null mice maintain an increased number of oligodendrocytes.
    7. Strong evidence is provided that murine cerebroside sulfotransferase localizes to the Golgi apparatus but not to the trans-Golgi network.
      Title: Cerebroside sulfotransferase forms homodimers in living cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables galactosylceramide sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylceramide sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosylceramide sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables galactosylceramide sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within galactosylceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactosylceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within glycolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    galactosylceramide sulfotransferase
    Names
    3'-phosphoadenosine-5'-phosphosulfate:Galcer sulfotransferase
    3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase
    Galcer sulfotransferase
    cerebroside sulfotransferase
    NP_001171162.1
    NP_001171174.1
    NP_001369219.1
    NP_001369220.1
    NP_058618.2
    XP_006514819.2
    XP_006514820.1
    XP_036012743.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177691.1 → NP_001171162.1  galactosylceramide sulfotransferase

      See identical proteins and their annotated locations for NP_001171162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as form E) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK002510, AK007645, AL807395, BB804195
      Consensus CDS
      CCDS24373.1
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Related
      ENSMUSP00000105608.2, ENSMUST00000109981.2
      Conserved Domains (1) summary
      cl22970
      Location:4 → 408
      Sulfotransfer_2; Sulfotransferase family

    2. NM_001177703.1 → NP_001171174.1  galactosylceramide sulfotransferase

      See identical proteins and their annotated locations for NP_001171174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK007645, AL807395, BB804195, CX239940
      Consensus CDS
      CCDS24373.1
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Related
      ENSMUSP00000077815.2, ENSMUST00000078757.8
      Conserved Domains (1) summary
      cl22970
      Location:4 → 408
      Sulfotransfer_2; Sulfotransferase family

    3. NM_001382290.1 → NP_001369219.1  galactosylceramide sulfotransferase

      Status: VALIDATED

      Source sequence(s)
      AL807395
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4 → 408
      Sulfotransfer_2; Sulfotransferase family

    4. NM_001382291.1 → NP_001369220.1  galactosylceramide sulfotransferase

      Status: VALIDATED

      Source sequence(s)
      AL807395
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4 → 408
      Sulfotransfer_2; Sulfotransferase family

    5. NM_016922.3 → NP_058618.2  galactosylceramide sulfotransferase

      See identical proteins and their annotated locations for NP_058618.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as form A) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. An in-frame AUG is located 29 codons upstream of the annotated translation start site but is not being annotated as a start site since it would be inhibited by an overlapping uORF with a strong Kozak sequence.
      Source sequence(s)
      AK007645, AL807395, BB804195, CX239940
      Consensus CDS
      CCDS24373.1
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Related
      ENSMUSP00000058348.8, ENSMUST00000063004.14
      Conserved Domains (1) summary
      cl22970
      Location:4 → 408
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3933636..3949328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156850.1 → XP_036012743.1  galactosylceramide sulfotransferase isoform X2

      Conserved Domains (1) summary
      cl22970
      Location:28 → 437
      Sulfotransfer_2; Sulfotransferase family

    2. XM_006514757.5 → XP_006514820.1  galactosylceramide sulfotransferase isoform X1

      See identical proteins and their annotated locations for XP_006514820.1

      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4 → 408
      Sulfotransfer_2; Sulfotransferase family

    3. XM_006514756.5 → XP_006514819.2  galactosylceramide sulfotransferase isoform X1

      See identical proteins and their annotated locations for XP_006514819.2

      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4 → 408
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHE4.2 GenPept UniProtKB/Swiss-Prot:Q9JHE4

    Gene LinkOut

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