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    BCL3 BCL3 transcription coactivator [ Homo sapiens (human) ]

    Gene ID: 602, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BCL3provided by HGNC
    Official Full Name
    BCL3 transcription coactivatorprovided by HGNC
    Primary source
    HGNC:HGNC:998
    See related
    Ensembl:ENSG00000069399 MIM:109560; AllianceGenome:HGNC:998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCL4; D19S37
    Summary
    This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.4), small intestine (RPKM 7.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BCL3 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44747705..44760044)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47566894..47584794)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45251965..45263301)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3873 Neighboring gene uncharacterized LOC107985306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192479-45192980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192981-45193480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45199988-45200593 Neighboring gene CEACAM16, CEACAM19 and PVR antisense RNA 1 Neighboring gene CEA cell adhesion molecule 16, tectorial membrane component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45240385-45240886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45258284-45258994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45259896-45260547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45261851-45262500 Neighboring gene uncharacterized LOC124900431 Neighboring gene microRNA 8085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14772 Neighboring gene Cbl proto-oncogene C Neighboring gene MPRA-validated peak3507 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14773

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. Büchau AS, et al. J Invest Dermatol, 2009 Sep. PMID 19282837, Free PMC Article
    2. Bcl3: a regulator of NF-κB inducible by TWEAK in acute kidney injury with anti-inflammatory and antiapoptotic properties in tubular cells. Poveda J, et al. Exp Mol Med, 2017 Jul 7. PMID 28684863, Free PMC Article
    3. B-cell CLL/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic STAT3 pathway. Wu J, et al. Int J Oncol, 2016 Dec. PMID 27748795
    4. Role of Bcl-3 in the development of follicular helper T cells and in the pathogenesis of rheumatoid arthritis. Meguro K, et al. Arthritis Rheumatol, 2015 Oct. PMID 26138292
    5. Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients. Dimitrakopoulos FI, et al. Lung Cancer, 2015 Sep. PMID 26122346

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases.
      Title: BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases.
    2. Bcl-3 regulates T cell function through energy metabolism.
      Title: Bcl-3 regulates T cell function through energy metabolism.
    3. Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT signaling.
      Title: Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFβ/Smad3/EMT signaling.
    4. Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure.
      Title: Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure.
    5. Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.
      Title: Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.
    6. Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
      Title: Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
    7. Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer.
      Title: Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer.
    8. PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3.
      Title: PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3.
    9. Bcl-3 promotes multi-modal tumour cell migration via NF-kappaB1 mediated regulation of Cdc42.
      Title: Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42.
    10. BCL-3 and beta-catenin signaling and tumor staging in colorectal cancer.
      Title: BCL-3 and β-catenin signaling and tumor staging in colorectal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Leukemia/lymphoma, B-cell, 3
    MedGen: CN375896 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
    EBI GWAS Catalog
    Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
    EBI GWAS Catalog
    SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of B-cell CLL/lymphoma 3 (BCL3) in human B cells PubMed
    Tat tat HIV-1 Tat upregulates the expression of B-cell CLL/lymphoma 3 (BCL3) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T-helper 1 type immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T-helper 2 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antimicrobial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to protozoan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in follicular dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germinal center formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in marginal zone B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA binding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of non-canonical NF-kappaB signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to UV-C IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Bcl3-Bcl10 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Bcl3/NF-kappaB2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Bcl3/NF-kappaB2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-cell lymphoma 3 protein
    Names
    B cell CLL/lymphoma 3
    B-cell leukemia/lymphoma 3
    B-cell lymphoma 3-encoded protein
    BCL-3
    chronic lymphatic leukemia protein
    proto-oncogene BCL3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052809.1 RefSeqGene

      Range
      11088..22424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005178.5 → NP_005169.2  B-cell lymphoma 3 protein

      See identical proteins and their annotated locations for NP_005169.2

      Status: REVIEWED

      Source sequence(s)
      AC092066, BC064993, BU501187
      Consensus CDS
      CCDS12642.2
      UniProtKB/Swiss-Prot
      P20749
      Related
      ENSP00000164227.5, ENST00000164227.10
      Conserved Domains (2) summary
      sd00045
      Location:241 → 272
      ANK; ANK repeat [structural motif]
      cl39094
      Location:137 → 334
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44747705..44760044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027110.2 → XP_016882599.1  B-cell lymphoma 3 protein isoform X2

      UniProtKB/TrEMBL
      B7Z3N9
      Related
      ENST00000403534.7
      Conserved Domains (4) summary
      cd00204
      Location:160 → 289
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:170 → 265
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:117 → 172
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:201 → 232
      ANK; ANK repeat [structural motif]

    2. XM_011527198.4 → XP_011525500.3  B-cell lymphoma 3 protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      47566894..47584794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321687.1 → XP_054177662.1  B-cell lymphoma 3 protein isoform X4

    2. XM_054321686.1 → XP_054177661.1  B-cell lymphoma 3 protein isoform X3

    3. XM_054321688.1 → XP_054177663.1  B-cell lymphoma 3 protein isoform X5

    4. XM_054321692.1 → XP_054177667.1  B-cell lymphoma 3 protein isoform X2

      UniProtKB/TrEMBL
      B7Z3N9

    5. XM_054321689.1 → XP_054177664.1  B-cell lymphoma 3 protein isoform X6

    6. XM_054321690.1 → XP_054177665.1  B-cell lymphoma 3 protein isoform X7

    7. XM_054321691.1 → XP_054177666.1  B-cell lymphoma 3 protein isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20749.2 GenPept UniProtKB/Swiss-Prot:P20749

    Gene LinkOut

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