MYLK myosin light chain kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYLKprovided by HGNC
Official Full Name: myosin light chain kinaseprovided by HGNC
Primary source: HGNC:HGNC:7590
See related: Ensembl:ENSG00000065534 MIM:600922; AllianceGenome:HGNC:7590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KRP; AAT7; MLCK; MLCK1; MMIHS; MYLK1; MMIHS1; MYLK-L; smMLCK; MLCK108; MLCK210; MSTP083
Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Expression: Broad expression in prostate (RPKM 187.5), endometrium (RPKM 154.5) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q21.1

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (123610049..123884332, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (126330173..126610461, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (123328896..123603179, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
Title: The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
Title: Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression.
Title: The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression.
SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
Title: SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.
Title: CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.
Procyanidin A1 and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway.
Title: Procyanidin A(1) and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway.
Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis.
Title: Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis.
CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
Title: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
Title: A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2.
Title: Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MYLK that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Aortic aneurysm, familial thoracic 7 MedGen: C3151077 OMIM: 613780 GeneReviews: Heritable Thoracic Aortic Disease Overview	Compare labs
Familial thoracic aortic aneurysm and aortic dissection MedGen: C4707243 GeneReviews: Heritable Thoracic Aortic Disease Overview	Compare labs
Megacystis-microcolon-intestinal hypoperistalsis syndrome 1 MedGen: C5542316 OMIM: 249210 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2016-01-14) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2016-01-14) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat in combination with morphine activates myosin light chain kinase expression in primary brain micro vascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH77851 (e-PCR)
- UniSTS:45321

D11S2921 (e-PCR)
- UniSTS:152074

RH45477 (e-PCR)
- UniSTS:10789

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-77271 (e-PCR)
- UniSTS:26682

L18426 (e-PCR)
- UniSTS:34648

RH36624 (e-PCR)
- UniSTS:67934

SHGC-107378 (e-PCR)
- UniSTS:170359

A006U08 (e-PCR)
- UniSTS:28559

GDB:335751 (e-PCR)
- UniSTS:156601

A004V23 (e-PCR)
- UniSTS:57532

RH103400 (e-PCR)
- UniSTS:97726

SHGC-77279 (e-PCR)
- UniSTS:20684

D3S1668 (e-PCR)
- UniSTS:148442

GDB:631802 (e-PCR)
- UniSTS:158429

SHGC-77269 (e-PCR)
- UniSTS:53737

NoName (e-PCR)
- UniSTS:484085

D3S3552 (e-PCR)
- UniSTS:48381

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin light chain kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin light chain kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in aorta smooth muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bleb assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular hypotonic response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in tonic smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in tonic smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin light chain kinase, smooth muscle

Names: kinase-related protein; myosin, light polypeptide kinase; smooth muscle myosin light chain kinase; telokin

NP_001308238.1

EC 2.7.11.18

NP_444253.3

EC 2.7.11.18

NP_444254.3

EC 2.7.11.18

NP_444255.3

EC 2.7.11.18

NP_444256.3

EC 2.7.11.18

NP_444259.1

EC 2.7.11.18

NP_444260.1

EC 2.7.11.18

XP_011511162.2

EC 2.7.11.18

XP_011511163.2

EC 2.7.11.18

XP_016861958.2

EC 2.7.11.18

XP_016861959.1

EC 2.7.11.18

XP_016861960.1

EC 2.7.11.18

XP_016861961.1

EC 2.7.11.18

XP_016861962.1

EC 2.7.11.18

XP_024309300.1

EC 2.7.11.18

XP_024309302.1

EC 2.7.11.18

XP_024309305.1

EC 2.7.11.18

XP_047304138.1

EC 2.7.11.18

XP_047304139.1

EC 2.7.11.18

XP_047304140.1

EC 2.7.11.18

XP_047304141.1

EC 2.7.11.18

XP_047304142.1

EC 2.7.11.18

XP_047304143.1

EC 2.7.11.18

XP_047304144.1

EC 2.7.11.18

XP_054202587.1

EC 2.7.11.18

XP_054202588.1

EC 2.7.11.18

XP_054202589.1

EC 2.7.11.18

XP_054202590.1

EC 2.7.11.18

XP_054202591.1

EC 2.7.11.18

XP_054202592.1

EC 2.7.11.18

XP_054202593.1

EC 2.7.11.18

XP_054202594.1

EC 2.7.11.18

XP_054202595.1

EC 2.7.11.18

XP_054202596.1

EC 2.7.11.18

XP_054202597.1

EC 2.7.11.18

XP_054202598.1

EC 2.7.11.18

XP_054202599.1

EC 2.7.11.18

XP_054202600.1

EC 2.7.11.18

XP_054202601.1

EC 2.7.11.18

XP_054202602.1

EC 2.7.11.18

XP_054202603.1

EC 2.7.11.18

XP_054202604.1

EC 2.7.11.18

XP_054202605.1

EC 2.7.11.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029111.2 RefSeqGene

Range

5000..279283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001321309.2 → NP_001308238.1 myosin light chain kinase, smooth muscle isoform 9

Status: REVIEWED

Source sequence(s)

AC020634, AC023165, AC117381, AY339601, BC064695, BC113458, BQ006428, DA853780, U48959

UniProtKB/TrEMBL

A0A8I5QKL9

Conserved Domains (9) summary

cd00096
Location:464 → 533

Ig; Immunoglobulin domain

cd05762
Location:1062 → 1159

Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)

smart00408
Location:1646 → 1713

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1155 → 1247

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1633 → 1723

I-set; Immunoglobulin I-set domain

cd14191
Location:1285 → 1543

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam00069
Location:1288 → 1543

Pkinase; Protein kinase domain

pfam16620
Location:75 → 236

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

cl11960
Location:548 → 633

Ig; Immunoglobulin domain
NM_053025.4 → NP_444253.3 myosin light chain kinase, smooth muscle isoform 1

See identical proteins and their annotated locations for NP_444253.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the full-length transcript and encodes the full-length nonmuscle isoform.

Source sequence(s)

AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959

Consensus CDS

CCDS46896.1

UniProtKB/Swiss-Prot

B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9

UniProtKB/TrEMBL

A0A8I5QKL9

Related

ENSP00000353452.3, ENST00000360304.8

Conserved Domains (5) summary

cd05762
Location:1238 → 1335

Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains

cd00063
Location:1331 → 1423

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1809 → 1899

I-set; Immunoglobulin I-set domain

cd14191
Location:1461 → 1719

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam16620
Location:251 → 412

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
NM_053026.4 → NP_444254.3 myosin light chain kinase, smooth muscle isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) does not utilize exon 11, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959

Consensus CDS

CCDS43141.1

UniProtKB/TrEMBL

A0A8I5QKL9

Related

ENSP00000510503.1, ENST00000693689.1

Conserved Domains (5) summary

cd05762
Location:1169 → 1266

Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains

cd00063
Location:1262 → 1354

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1740 → 1830

I-set; Immunoglobulin I-set domain

cd14191
Location:1392 → 1650

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam16620
Location:251 → 412

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
NM_053027.4 → NP_444255.3 myosin light chain kinase, smooth muscle isoform 3A

Status: REVIEWED

Description

Transcript Variant: This variant (3A) does not utilize exon 30, compared to variant 1, resulting in a shorter protein (isoform 3A), compared to isoform 1.

Source sequence(s)

AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959

Consensus CDS

CCDS3023.1

UniProtKB/TrEMBL

A0A8I5QKL9

Related

ENSP00000354004.3, ENST00000360772.7

Conserved Domains (9) summary

cd00096
Location:640 → 709

Ig; Immunoglobulin domain

cd05762
Location:1238 → 1335

Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)

smart00408
Location:1771 → 1838

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1331 → 1423

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1758 → 1848

I-set; Immunoglobulin I-set domain

pfam00069
Location:1464 → 1668

Pkinase; Protein kinase domain

pfam16620
Location:251 → 412

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

cl11960
Location:724 → 809

Ig; Immunoglobulin domain

cl21453
Location:1461 → 1668

PKc_like; Protein Kinases, catalytic domain
NM_053028.4 → NP_444256.3 myosin light chain kinase, smooth muscle isoform 3B

Status: REVIEWED

Description

Transcript Variant: This variant (3B) does not utilize exons 11 and 30, compared to variant 1, resulting in a shorter protein (isoform 3B), compared to isoform 1.

Source sequence(s)

AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959

Consensus CDS

CCDS93356.1

UniProtKB/TrEMBL

A0A8I5QKL9

Related

ENSP00000320622.6, ENST00000346322.10

Conserved Domains (9) summary

cd00096
Location:571 → 640

Ig; Immunoglobulin domain

cd05762
Location:1169 → 1266

Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)

smart00408
Location:1702 → 1769

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1262 → 1354

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1689 → 1779

I-set; Immunoglobulin I-set domain

pfam00069
Location:1395 → 1599

Pkinase; Protein kinase domain

pfam16620
Location:251 → 412

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

cl11960
Location:655 → 740

Ig; Immunoglobulin domain

cl21453
Location:1392 → 1599

PKc_like; Protein Kinases, catalytic domain
NM_053031.4 → NP_444259.1 myosin light chain kinase, smooth muscle isoform 7

See identical proteins and their annotated locations for NP_444259.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) encodes the shorter isoform of kinase related protein, telokin. The first exon corresponds to intron 30 and the remainder of the transcript corresponds to the last two exons of the gene. It is shorter than variant 8 by one codon at the splicing junction between the first two exons.

Source sequence(s)

AC023165, BC064420, BC113458, DB016380

Consensus CDS

CCDS58849.1

UniProtKB/TrEMBL

Q05B97

Related

ENSP00000510047.1, ENST00000685744.1

Conserved Domains (1) summary

cd20973
Location:51 → 138

IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
NM_053032.4 → NP_444260.1 myosin light chain kinase, smooth muscle isoform 8

See identical proteins and their annotated locations for NP_444260.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) encodes the longer isoform of kinase related protein, telokin. It is longer than variant 7 by one codon at the splicing junction between the first two exons.

Source sequence(s)

AC023165, BC064420, BC113456, DB016380

Consensus CDS

CCDS46897.1

UniProtKB/TrEMBL

Q05B97

Related

ENSP00000428967.1, ENST00000418370.6

Conserved Domains (1) summary

cd20973
Location:52 → 139

IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

123610049..123884332 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448184.1 → XP_047304140.1 myosin light chain kinase, smooth muscle isoform X7

UniProtKB/Swiss-Prot

B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
XM_024453532.2 → XP_024309300.1 myosin light chain kinase, smooth muscle isoform X6

UniProtKB/TrEMBL

A0A8I5KU53, A0A8I5QKL9

Related

ENSP00000508761.1, ENST00000687848.1

Conserved Domains (5) summary

cd05762
Location:1248 → 1345

Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains

cd00063
Location:1341 → 1433

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1819 → 1909

I-set; Immunoglobulin I-set domain

cd14191
Location:1471 → 1729

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam16620
Location:261 → 422

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
XM_047448183.1 → XP_047304139.1 myosin light chain kinase, smooth muscle isoform X6

UniProtKB/TrEMBL

A0A8I5KU53
XM_047448187.1 → XP_047304143.1 myosin light chain kinase, smooth muscle isoform X6

UniProtKB/TrEMBL

A0A8I5KU53
XM_047448186.1 → XP_047304142.1 myosin light chain kinase, smooth muscle isoform X8
XM_017006469.3 → XP_016861958.2 myosin light chain kinase, smooth muscle isoform X5
XM_024453534.2 → XP_024309302.1 myosin light chain kinase, smooth muscle isoform X3

UniProtKB/TrEMBL

A0A8I5QKL9

Related

ENSP00000508777.1, ENST00000690457.1

Conserved Domains (5) summary

cd05762
Location:1179 → 1276

Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains

cd00063
Location:1272 → 1364

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1750 → 1840

I-set; Immunoglobulin I-set domain

cd14191
Location:1402 → 1660

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam16620
Location:261 → 422

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
XM_047448182.1 → XP_047304138.1 myosin light chain kinase, smooth muscle isoform X4
XM_011512861.4 → XP_011511163.2 myosin light chain kinase, smooth muscle isoform X2

UniProtKB/TrEMBL

A0A8I5QKL9

Conserved Domains (5) summary

cd05762
Location:1248 → 1345

Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains

cd00063
Location:1341 → 1433

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1751 → 1841

I-set; Immunoglobulin I-set domain

pfam16620
Location:261 → 422

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

cl21453
Location:1483 → 1661

PKc_like; Protein Kinases, catalytic domain
XM_011512860.4 → XP_011511162.2 myosin light chain kinase, smooth muscle isoform X1

UniProtKB/TrEMBL

A0A8I5QKL9

Conserved Domains (5) summary

cd05762
Location:1248 → 1345

Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains

cd00063
Location:1341 → 1433

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1818 → 1908

I-set; Immunoglobulin I-set domain

cd14191
Location:1471 → 1729

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam16620
Location:261 → 422

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
XM_024453537.2 → XP_024309305.1 myosin light chain kinase, smooth muscle isoform X7

UniProtKB/Swiss-Prot

B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9

UniProtKB/TrEMBL

A0A8I5QKL9

Related

ENSP00000508758.1, ENST00000686761.1

Conserved Domains (5) summary

cd05762
Location:1238 → 1335

Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains

cd00063
Location:1331 → 1423

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1809 → 1899

I-set; Immunoglobulin I-set domain

cd14191
Location:1461 → 1719

STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1

pfam16620
Location:251 → 412

23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
XM_047448185.1 → XP_047304141.1 myosin light chain kinase, smooth muscle isoform X7

UniProtKB/Swiss-Prot

B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
XM_047448188.1 → XP_047304144.1 myosin light chain kinase, smooth muscle isoform X11
XM_017006470.3 → XP_016861959.1 myosin light chain kinase, smooth muscle isoform X10

UniProtKB/TrEMBL

A0A8I5KTQ1

Related

ENSP00000510593.1, ENST00000685953.1
XM_017006471.3 → XP_016861960.1 myosin light chain kinase, smooth muscle isoform X9

UniProtKB/Swiss-Prot

Q15746

Related

ENSP00000422984.2, ENST00000508240.2

Conserved Domains (4) summary

cd00063
Location:131 → 223

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05762
Location:37 → 135

IgI_8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar protein; member of the I-set of IgSF domains

cd20973
Location:612 → 699

IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

cl21453
Location:261 → 519

PKc_like; Protein Kinases, catalytic domain
XM_017006473.2 → XP_016861962.1 myosin light chain kinase, smooth muscle isoform X13

UniProtKB/TrEMBL

Q05B97

Related

ENSP00000509867.1, ENST00000687375.1

Conserved Domains (1) summary

cd20973
Location:51 → 138

IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
XM_017006472.3 → XP_016861961.1 myosin light chain kinase, smooth muscle isoform X12

UniProtKB/TrEMBL

Q05B97

Related

ENSP00000462118.1, ENST00000583087.6

Conserved Domains (1) summary

cd20973
Location:52 → 139

IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

126330173..126610461 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054346621.1 → XP_054202596.1 myosin light chain kinase, smooth muscle isoform X7
XM_054346619.1 → XP_054202594.1 myosin light chain kinase, smooth muscle isoform X6
XM_054346625.1 → XP_054202600.1 myosin light chain kinase, smooth muscle isoform X6
XM_054346616.1 → XP_054202591.1 myosin light chain kinase, smooth muscle isoform X4
XM_054346614.1 → XP_054202589.1 myosin light chain kinase, smooth muscle isoform X2
XM_054346612.1 → XP_054202587.1 myosin light chain kinase, smooth muscle isoform X1
XM_054346624.1 → XP_054202599.1 myosin light chain kinase, smooth muscle isoform X8
XM_054346617.1 → XP_054202592.1 myosin light chain kinase, smooth muscle isoform X5
XM_054346613.1 → XP_054202588.1 myosin light chain kinase, smooth muscle isoform X7
XM_054346618.1 → XP_054202593.1 myosin light chain kinase, smooth muscle isoform X14
XM_054346615.1 → XP_054202590.1 myosin light chain kinase, smooth muscle isoform X3
XM_054346622.1 → XP_054202597.1 myosin light chain kinase, smooth muscle isoform X7
XM_054346620.1 → XP_054202595.1 myosin light chain kinase, smooth muscle isoform X6
XM_054346623.1 → XP_054202598.1 myosin light chain kinase, smooth muscle isoform X7
XM_054346628.1 → XP_054202603.1 myosin light chain kinase, smooth muscle isoform X9
XM_054346627.1 → XP_054202602.1 myosin light chain kinase, smooth muscle isoform X11
XM_054346626.1 → XP_054202601.1 myosin light chain kinase, smooth muscle isoform X10

UniProtKB/TrEMBL

A0A8I5KTQ1
XM_054346630.1 → XP_054202605.1 myosin light chain kinase, smooth muscle isoform X13
XM_054346629.1 → XP_054202604.1 myosin light chain kinase, smooth muscle isoform X12

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_005965.3: Suppressed sequence

Description

NM_005965.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_053029.2: Suppressed sequence

Description

NM_053029.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_053030.2: Suppressed sequence

Description

NM_053030.2: This RefSeq was permanently suppressed because there was insufficient support for the transcript and the CDS was partial.